Opioids OxyContin MR/ER + Grapefruit Juice

[VoyagerFun]

Hi! I ordered 4x 30mg Modified Release.
I planned on crushing it up and mixing it with Grapefruit but realised after ordering that it isn’t crushable.

Now I’m in a pickle as the Grapefruit not only potentiates OC, but also makes it last longer.
I’m worried that the initial 1/3rd will lapse over into the slow release of the other 2/3rd building up into a potentially lethal dose.

Without the grapefruit I could handle (60mg MR) but with grapefruit I’m not so sure.

Im also worried that just one pill (30mg MR) wouldn’t be enough.

Or maybe it is enough. I’m not sure.

Whats everyone’s experience mixing OC MR/ER with grapefruit?

Thanks in advance.

 

[Cult315]

My experience with ER opiates is pretty limited, and I don’t know if what I’m going to say actually helps anything at all or if it’s advisable. Just wanted to share personal experience and the fact that I’m alive after doing so, and it never seemed to be “too much” or anything

I used to get 100mg Nucynta(Tapentadol) ER for next to nothing. They kind of sucked but they kept me out of WDs for a few months. Anyway they were solid ass pills, like I assume the Oxy ER are. The only upside was these were oblong, IMO making them easier for my fat fingers to cut, so I used a pair of pruning shears to cut them into as small of pieces as I could. Depending on how bad my wrists and grip was that day I could usually get them into 6-8 little pieces, but some days could barely manage 4 lol. I’d do 2 of them and swallow all the little pieces at once, I think the time release still worked a bit but it definitely made them hit much harder than taking them whole.

Be warned - if you do try this you have to hold the pill(otherwise it just slips out, sometimes goes flying across the room and playing hide and seek with drugs is not fun) and the risk of cutting the shit out of your fingers is pretty high. It’s easy not to if you’re careful, but I watch people cut themselves badly often because of stupid, simple mistakes. I managed to never cut myself but I posses a skill most people don’t with sharp objects

Just so you know scissors are not the same thing and will not work the same. You’re even more likely to hurt yourself even trying so I wouldn’t recommend it. Pruning shears work great because they’re made for cutting thick materials with minimal effort, scissors are not.

But do you normally have a tolerance for 60mg of oxy? Or close to it? I don’t know how well grapefruit juice works vs other potentiators, I usually stuck with DXM/benzos and I barely ever got anything out of Oxy ER, but I also never had the thought to cut them up when I was getting them. I just remember taking 90-120mg(with tolerance, definitely don’t take that much if you can’t normally take that much) and I was perpetually stuck with the feeling that the blanket was about to come, and then it never did. Essentially Oxy ER just gave me blue balls, just kept jerkin me enough to make me feel like I was about to feel great, and never did.

 

[Dextro .45]

White grapefruit juice from concentrate inhibits the enzymes responsible for metabolizing Methadone.....so higher levels are in the bloodstream and for a longer duration as it's not being metabolized as quickly as normal

But won't do shit coming off 100mg Methadone.....in 2 to 3 days you'll be curled up in a cold sweaty ball on the ground contemplating going into a pharmacy with a handgun lol.....just seek medical help.

There has to be a clinic that will safely and slowly taper you off.....has to be.

 

[Cult315]

White grapefruit juice from concentrate inhibits the enzymes responsible for metabolizing Methadone.....so higher levels are in the bloodstream and for a longer duration as it's not being metabolized as quickly as normal

But won't do shit coming off 100mg Methadone.....in 2 to 3 days you'll be curled up in a cold sweaty ball on the ground contemplating going into a pharmacy with a handgun lol.....just seek medical help.

There has to be a clinic that will safely and slowly taper you off.....has to be.

Am I missing something or where does it say anything about methadone? I think you’re responding to 2 different threads at once homie lol. I doubt somebody on 100mg of methadone would be concerned about ODing on 60mg oxy no matter how they take it

 

[Keif' Richards]

That's a difficult question to answer precisely. The enzymatic effects are caused by flavonoids in stuff like Grapefruit, Bergamot and other related fruits. You could perhaps look deeper into the biology of the flavonoids, but that's probably a lot of reading.

You'd be better off just figuring it out through trial and error. Nothing is going to give you a clearer answer than trials on yourself. If you're worried about the dose, take less.

Frankly, I've never actually met a person for whom Grapefruit actually made a truly significant difference in the drugs they were taking. Even in the "best" scenarios, I have people telling stories that they cannot truly reject the idea that it's in their head. If Grapefruit juice is actually causing you to get really messed up, then it's possible you have some unique biology that makes you susceptible.

Most of what I've read on Grapefruit-related drug-interactions indicate the possibility of a 10%-15% increase in drug levels, but this was in people who were drinking grapefruit juice every morning.

 

[VoyagerFun]

White grapefruit juice from concentrate inhibits the enzymes responsible for metabolizing Methadone.....so higher levels are in the bloodstream and for a longer duration as it's not being metabolized as quickly as normal

But won't do shit coming off 100mg Methadone.....in 2 to 3 days you'll be curled up in a cold sweaty ball on the ground contemplating going into a pharmacy with a handgun lol.....just seek medical help.

There has to be a clinic that will safely and slowly taper you off.....has to be.

I’m not withdrawing or frequently taking Opioids.

I’ve taken Oxy a hand full of times and can handle strong effects but i didn’t know how Grapefruit influences the effects, on top of the fact that it was a delayed release.

 

[Dextro .45]

Oh sorry....it has to be WHITE grapefruit juice from concentrate Mc Caines juice....it inhibits the liver enzymes responsible for metabolizing Methadone

OxyContin just has wax layers / delayed binders / between the layers of API & excipients that release measured amounts of medication over 8-10h

Crushing tablets defeats this turning it into an IR formula

 

[VoyagerFun]

Oh sorry....it has to be WHITE grapefruit juice from concentrate Mc Caines juice....it inhibits the liver enzymes responsible for metabolizing Methadone

OxyContin just has wax layers / delayed binders / between the layers of API & excipients that release measured amounts of medication over 8-10h

Crushing tablets defeats this turning it into an IR formula

The brand I have is newer is not crushable so iv been told. The vendor has no reason to tell a lie that lowers the value of the pill. Not that he even offered a cheaper price.

I had gotten an 80mg OG OxyContin before this guy and was much cheaper then the 30mg uncrushables.

But honestly both of them feel terrible compared to my memory of when did OxyCodone. Is there a difference?