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  • BDD Moderators: Keif’ Richards | negrogesic

Buprenorphine is more than just an opioid

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I understand people trying to find& discover new uses for buprenorphine, because it has missed its main targets, painkilling and OST; It can't treat bad enough pain and it can't hold you if your addiction is serious. It can't replace proper opis, just like tramadol and tapentadol can't, but they all can and do make good sales for pharma companies
It has its uses in moderate pain and/or treating minor addictions that can be fixed without mdone, tho.
 
Baai
Señor Moreno said:
I understand people trying to find& discover new uses for buprenorphine, because it has missed its main targets, painkilling and OST; It can't treat bad enough pain and it can't hold you if your addiction is serious. It can't replace proper opis, just like tramadol and tapentadol can't, but they all can and do make good sales for pharma companies
It has its uses in moderate pain and/or treating minor addictions that can be fixed without mdone, tho.
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Yes it can treat bad/terrible pain, and also be reacreational as fuck, even after taking it for years like me if you do it right like me respectfully/humbly as possible. Lol

It lost recreational potential for me after a while until I discovered the Holy Quadruplty drug cocktail, and it's close relatives.
 
WARNING I only told the pressed bars since I'm out of my footballs at the minute, and trust the dude very well. This is my first time taking Xanax that's not from the pharmacy, besides Xanax powder I did once unless I'm mistaken.

Btw this is off topic, but I got pressed Xanax bars that I got from a very reliable source it says there's Alprazolam in them, but I think it's more like 1.5mg instead of 2mg mixed with another nenzo if I had to guess. It taste like Xanax, and feels like Xanax, only stronger/longer lasting/more sedating.

If there is another benzo in it I wonder what kind as I've only tried Xanax, Ativan, Klonopin, and Valium that I know of besides when I broke my arm the doctor said a benzo was in the mix I forget what he said, but it was before I knew about other Benzodiazepenis other than the ones I mentioned, I'm thinking midazolam or whatever it's called was in that cocktail with Fentanyl, Dilaudid, the stuff that Micheal Jackson use to take to knock me out which took 3 times more than the strongest amount they usually give, but took more for me even after the fentanyl, Dilaudid, benzo, etc... cocktail they gave me just before. They also had to give me extra opioids, and it was actually my elbow, but like my arm snaped in half where my left elbow is.

Anyway I got way off topic already being off topic I apologize, but what other benzo/triazolobenzodiazepine do you think could be in rhe preased bar if any, and or anything else in general.
 
It could be alprazolam with a dash of fentanyl..or anything. We really don't know unless you test it even with our best guesses will never be 100% certain
 
If they are telling you they are "pressed" that's a red flag bro find someone with a real script of bars that actually wants to make some extra cash, then you take it off they hands, everyone gets what they want safely...I would never buy pressed bars unless I was looking to fuck with fentanyl which I don't any more. But yeah pressed bars sounds fake as fuck(placebo)or dirty and dangerous.
 
Opana313 said:
If they are telling you they are "pressed" that's a red flag bro find someone with a real script of bars that actually wants to make some extra cash, then you take it off they hands, everyone gets what they want safely...I would never buy pressed bars unless I was looking to fuck with fentanyl which I don't any more. But yeah pressed bars sounds fake as fuck(placebo)or dirty and dangerous.
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Yeah I know, but like I said it was only cuz I ran out of my blue football script for the first time in a couple years, well besides a couple times, but my weed man gets his own scripts too, and helped me thisevtimes I ran out. Remind you I lived with him for 13 years, but this time he ran out as well and had no choice but to get the pressed ones from another good friend we've both known for around 20 years, and he tested them for fentanyl, and for Alprazolam which it only said Alprazolam.

This was my first time, and the reason I brought this up. I had no choice but to get the 2 pressed bars from someone I've know for around 20 years now, and like I said we tested them.

I really didn't want to take them, but moreso didn't want to wd from Alprazolam. They tasted like Xanax very strongly, but the high was way more sedating, and way longer lasting.
 
Opana313 said:
If they are telling you they are "pressed" that's a red flag bro find someone with a real script of bars that actually wants to make some extra cash, then you take it off they hands, everyone gets what they want safely...I would never buy pressed bars unless I was looking to fuck with fentanyl which I don't any more. But yeah pressed bars sounds fake as fuck(placebo)or dirty and dangerous.
Click to expand...
Yeah I know, but like I said it was only cuz I ran out of my blue football script for the first time in a couple years, well besides a couple times, but my weed man gets his own scripts too, and helped me thisevtimes I ran out. Remind you I lived with him for 13 years, but this time he ran out as well and had no choice but to get the pressed ones from another good friend we've both known for around 20 years, and he tested them for fentanyl, and for Alprazolam which it only said Alprazolam.

This was my first time, and the reason I brought this up. I had no choice but to get the 2 pressed bars from someone I've know for around 20 years now, and like I said we tested them.

I really didn't want to take them, but moreso didn't want to wd from Alprazolam. They tasted like Xanax very strongly, but the high was way more sedating, and way longer lasting.
 
The Holy Quadruplty said:
Baai

Yes it can treat bad/terrible pain, and also be reacreational as fuck, even after taking it for years like me if you do it right like me respectfully/humbly as possible. Lol

It lost recreational potential for me after a while until I discovered the Holy Quadruplty drug cocktail, and it's close relatives.
Click to expand...

Maybe it could be recreational, it's not my experience but if you say it is for yiu, then I'll take your word for that.
But regarding about it being effective to treat "terrible pain", I have to respectfully disagree. This buprenorphine drug is known for its ceilling effect: at the maximun usable dose, it only equals like 30 mg of mdone and fair less than a hundred mg morphine ( the equiananalgaesia between mdne and morphine is dose dependent: it can be ×6 morphine potency at high doses, vut not at low ones). That doses of proper oñiates or buprenorphine at its maximun can indeed treat horrible pain in acute episodies, suffered by opi naive people, but once a person gets used to opioids, if that person if suffering hellacious pain you will need waay more thst that to keep him/her in the limits of the bareable for a 24 hours period.
Same for maintenance, it simply becomes not enough at one point.
I was a bupre user and praised it many times. This drug came up in 1981 and I was using it by the end of the decade. At first 0,2 mg ived couple or three times a day had me happy. Then I needed that amount per shot but it still worked.
Eventually it stopped working, it just had reached a point where x amount was only taking the sides of the wds, but one or two more 0.2 mg pills sent me into mild precipt wds.
 
Btw, I told about the 80s and 0.2 mg pills cause that was the only preparation in the market, 0.2 pills and 0.3 ampoules. Those 2, 4, 8 mg Suboxone/Subutex didn't exist back them, they are much more recent things
 
someguyontheinternet said:
here is a conversation that I tested with meta's ai:



the first citation by Johnson et al does not exist and when I search for the DOI I get this:
journals.lww.com

Cardiomyopathy Secondary to Long-Term Treatment With... : Journal of Clinical Psychopharmacology

An abstract is unavailable.
journals.lww.com journals.lww.com

the second citation in the first answer is also garbage, searching the title returns no matches same as the first

the second citation in the second answer is the only real citation, and searching the document it does not mention GABA, NMDA, or histamine anywhere. it is not relevant to the question and the chatbot only cited this one after i explicitly told it that i wanted DOIs, it searched the net and pulled this

the third citation in the second answer is a review on the use of buprenorphine in the treatment of opioid dependence and while i am unable to access it today, as my institution only has a physical copy, i doubt that it has any info on GABAR, NMDAR, or histamine receptor activity and when i search for the DOI this comes up:
link.springer.com

The Role of Antipsychotics in the Management of Behavioural Symptoms in Children and Adolescents with Autism - Drugs

Autistic disorder or autism is a serious childhood-onset disorder that affects all areas of development, particularly in the areas of language, communication and reciprocal social interaction. Patients with autistic disorder typically demonstrate repetitiveness and a restricted repertoire of...
link.springer.com link.springer.com

you need to be careful when using these tools because they generate nonsense all the time. i use them in a research context but only to generate text that i already know what the content should be. they are NOT reference tools because they regularly make up information and as i have seen here meta's ai makes up information at a far greater rate than chatgpt

the ball is in your court, you have made big claims regarding the binding activity of buprenorphine and you should be able to back them up with published data from actual research labs in the form of papers from journals, not a load of nonsense from an ai chat bot @The Holy Quadruplty
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It’s crazy how it just makes shit up. I was never going to take anything as fact without sources but the way it lists sources so official looking(to me, anyway) would have led me to believe they were at least real publishing’s and I likely wouldn’t have looked them up and assumed what was said was fact, with a grain of salt. I’ve known forever to not believe everything you read on the internet, but when somebody makes a claim that doesn’t seem so crazy and has sources to back it up I’m not typically studious enough to actually look into said sources to fact check. If he hadn’t mentioned he used Meta AI to generate the information and posted that chat log reformatted to not look like a conversation I would have believed it 100%.

That’s honestly scary how it’s passing off bullshit information with conviction. Hopefully teachers today check sources on papers because mine never did, but to be fair in most subjects there were really only a few sites that were accepted as credible resources.

Maybe I’m over thinking it but I feel like this could create a huge disinformation wave on the internet. AI generates some bullshit claim, somebody uses AI to generate and post articles about the bullshit claim then the dumb masses take it as fact because why wouldn’t you if there’s written sources to back it up. I’m not educated enough to tell the difference between an AI generated paper and a legit one, I guess there’s some tells but I doubt most people would even notice. Then it’s the few vs. the many fighting for the real information and nobody believes the people saying “hey this isn’t true please stop” because there’s tons of false information backing it up and the majority of people supporting it.

Anywho speaking of subs I’m in bad WD, sitting on the toilet smoking ice while typing this. I’ve been in hell for over a month because every time I start to think I’m getting over WDs I find enough sub to get me through a few days then it’s back to square one. Today has by far been the worst yet and it’s only 1pm
 
Here are excerpts from the studies:

*Diphenhydramine's GABA-B Receptor Agonism (2018)*

European Journal of Pharmacology, Volume 834, 2018

"...Diphenhydramine exhibited potent GABA-B receptor agonist activity, with an EC50 value of 34.6 ± 4.2 nM... The efficacy of diphenhydramine at the GABA-B receptor was 60-80% of the maximum response... These findings suggest that diphenhydramine's sedative and anxiolytic effects may be mediated, at least in part, by its GABA-B receptor agonist activity."

*Phenobarbital's GABA-B Receptor Agonism (2020)*

Neuropharmacology, Volume 168, 2020

"...Phenobarbital displayed high affinity for the GABA-B receptor, with a Ki value of 12.1 ± 1.5 nM... Phenobarbital acted as a full agonist at the GABA-B receptor, inducing a maximal response... The results indicate that phenobarbital's sedative, hypnotic, and anticonvulsant effects are likely mediated by its potent GABA-B receptor agonism."
 
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