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  • BDD Moderators: Keif’ Richards | negrogesic

Buprenorphine is more than just an opioid

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The Holy Quadruplty

The Holy Quadruplty

Bluelighter
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Feb 9, 2022
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(I hope I posted this in the right forum as mods decided that I should only post on one of them, but I forget which one for sure. I'm pretty sure it is this one, and hope I'm not mistaken ofcourse).

I know this question may bother people, because this is kind of rare information, and may not be 100% accurate, but with the help of Meta AI I've found that Buprenorphine might be a moderate to strong NMDA receptor antagonist similar to DXM (Dextromethorphan).

Also it may be a GABA positive modulator or whatever it's called, (Increases GABA) and it works on GABAy if that's even anything. lol

I have even more info on it, and other receptors it binds to like the histamine receptor as an antagonist I believe?!

ILL POST MORE ANITHER YIME THOUGH.

BTW IM IN A HURRY TO WRITE THIS SO I MAY HAVE TO GO BACK LATER, AND FIX IT ALL IF NEEDED, AND/OR IF I REMEMBER TO AT LEAST. LOL

@forbiddendrugfacts
on Instagram has some info about it as well.
 
I guess it makes sense in a way being that it's maintenance drug.. but what do I know..either way, I appreciate this post..I am sure someone will come along and shed much more on this.
 
Using an off the shelf chatbot ai is about as accurate as putting a bunch of receptor names on paper, and putting them in a hat and pulling them out at random.

Like that's all nonsense. I'm beginning to become depressed at all of the fantasists playing medicinal chemist these days.

Edit: I worry that this post is a bit harsh. Misinformation upsets me because human knowledge is one of the only good and pure things out there. Posting grossly incorrect things will cause people to repeat what youve said and could have real world harm (say if somebody wanted to substitute buprenorphine for a benzo or something), and it will muddy the waters for everybody.

I am not angry with you personally, but this post kind of pushed me over the top in something that has been irking me for quite some time. I have been trying to be polite previously, but I worry that it goes unheard.
 
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AI at its finest, that and when you go to click a new song and its "AI" voiced and wrote. Damn it no, you can't just type the metronome bpm in and ask for a similar rhymescheme that rapper would be likely to use. It is more trash than mumble rap and autotuned combined
 
Skorpio said:
Using an off the shelf chatbot ai is about as accurate as putting a bunch of receptor names on paper, and putting them in a hat and pulling them out at random.

Like that's all nonsense. I'm beginning to become depressed at all of the fantasists playing medicinal chemist these days.

Edit: I worry that this post is a bit harsh. Misinformation upsets me because human knowledge is one of the only good and pure things out there. Posting grossly incorrect things will cause people to repeat what youve said and could have real world harm (say if somebody wanted to substitute buprenorphine for a benzo or something), and it will muddy the waters for everybody.

I am not angry with you personally, but this post kind of pushed me over the top in something that has been irking me for quite some time. I have been trying to be polite previously, but I worry that it goes unheard.
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Yes, but I had it recheck multiple times/ others things to get the information as right as possible. It gave me the souces it got the info from, and yes it made a good bit of mistakes that I corrected.

Actually I'm writing a book about DELIRIANTS BEING STRONGER THAN SOME STRAIGHT UP DISSOCIATIVES LIKE SCOPOLAMINE FOR EXAMPLE, but all I got to do is create the title, and the cover of the book.

Wana see some proof?!

I'm going to be selling the book so idk if im posting it on here, or not, well anytime soon at least.
 
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someguyontheinternet said:
I wasn't able to find any papers about buprenorphine and NMDAR or GABAR binding, I'm not inclined to believe that information

Also I just asked chatgpt and it said it didn't bind at those receptors. I think meta's ai just might suck
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I'm writing a book about it, I found a lot of resources using the Meta AI unlike when I've searched on the Google.
 
Opana313 said:
I guess it makes sense in a way being that it's maintenance drug.. but what do I know..either way, I appreciate this post..I am sure someone will come along and shed much more on this.
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Well I'm writing books about all of this, especially the one I'm working on now about the fact some deliriants are stronger DISSOCIATIVES than some very strong/potent Dissociative only drugs like Ketamine, and PCP for example.
 
The Holy Quadruplty said:
I'm writing a book about it, I found a lot of resources using the Meta AI unlike when I've searched on the Google.
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You'll need to link some research papers that back up your statements. Do you have any that you can share?

As I mentioned, I looked for references myself with pubmed and google scholar yet was unable to find anything at all. Without references this is essentially just misinformation
 
here is a conversation that I tested with meta's ai:

You
Does buprenorphine exhibit any NMDAR, GABAR, or histamine receptor binding

Meta AI
Receptor Binding Profile of Buprenorphine
Buprenorphine, a synthetic opioid, exhibits a complex receptor binding profile. While its primary mechanism of action involves partial agonism at mu-opioid receptors (MOR), it also exhibits affinity for other receptors, including:
  • NMDA Receptors: Buprenorphine has been shown to exhibit non-competitive NMDA receptor antagonism, which may contribute to its potential neuroprotective effects.
  • GABA Receptors: Buprenorphine does not exhibit significant binding affinity for GABA receptors.
  • Histamine Receptors: Buprenorphine has been shown to exhibit moderate affinity for histamine H1 receptors, which may contribute to its potential sedating effects.
It's important to note that buprenorphine's receptor binding profile is complex and may involve additional mechanisms beyond its primary MOR activity.
References:
  • Johnson et al. (2017). Buprenorphine: its pharmacology and therapeutic role in opioid addiction. Journal of Clinical Psychopharmacology, 37(5), 555-565.
  • Li et al. (2019). Buprenorphine: a review of its receptor binding profile and clinical applications. European Journal of Pharmacology, 853, 143-153.





You
please cite your references with DOIs

Meta AI
Receptor Binding Profile of Buprenorphine
Buprenorphine, a synthetic opioid, exhibits a complex receptor binding profile. While its primary mechanism of action involves partial agonism at mu-opioid receptors (MOR), it also exhibits affinity for other receptors, including:
  • NMDA Receptors: Buprenorphine has been shown to exhibit non-competitive NMDA receptor antagonism, which may contribute to its potential neuroprotective effects ¹.
  • GABA Receptors: Buprenorphine does not exhibit significant binding affinity for GABA receptors [2].
  • Histamine Receptors: Buprenorphine has been shown to exhibit moderate affinity for histamine H1 receptors, which may contribute to its potential sedating effects [3].
References:
  • Johnson et al. (2017). Buprenorphine: its pharmacology and therapeutic role in opioid addiction. Journal of Clinical Psychopharmacology, 37(5), 555-565. DOI: 10.1097/JCP.0000000000000848
  • De Aquino et al. (2021). The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation, 41(5), 425-435. DOI: 10.1007/s40261-021-00974-6
  • Orman & Keating (2009). Buprenorphine naloxone. Drugs, 69(5), 577–607. DOI: 10.2165/00003495-200969050-00003
Click to expand...

the first citation by Johnson et al does not exist and when I search for the DOI I get this:
journals.lww.com

Cardiomyopathy Secondary to Long-Term Treatment With... : Journal of Clinical Psychopharmacology

An abstract is unavailable.
journals.lww.com journals.lww.com

the second citation in the first answer is also garbage, searching the title returns no matches same as the first

the second citation in the second answer is the only real citation, and searching the document it does not mention GABA, NMDA, or histamine anywhere. it is not relevant to the question and the chatbot only cited this one after i explicitly told it that i wanted DOIs, it searched the net and pulled this

the third citation in the second answer is a review on the use of buprenorphine in the treatment of opioid dependence and while i am unable to access it today, as my institution only has a physical copy, i doubt that it has any info on GABAR, NMDAR, or histamine receptor activity and when i search for the DOI this comes up:
link.springer.com

The Role of Antipsychotics in the Management of Behavioural Symptoms in Children and Adolescents with Autism - Drugs

Autistic disorder or autism is a serious childhood-onset disorder that affects all areas of development, particularly in the areas of language, communication and reciprocal social interaction. Patients with autistic disorder typically demonstrate repetitiveness and a restricted repertoire of...
link.springer.com link.springer.com

you need to be careful when using these tools because they generate nonsense all the time. i use them in a research context but only to generate text that i already know what the content should be. they are NOT reference tools because they regularly make up information and as i have seen here meta's ai makes up information at a far greater rate than chatgpt

the ball is in your court, you have made big claims regarding the binding activity of buprenorphine and you should be able to back them up with published data from actual research labs in the form of papers from journals, not a load of nonsense from an ai chat bot @The Holy Quadruplty
 
The Holy Quadruplty said:
Like I said I wrote almost a hole book about the Dissociative effects of DELIRIANTS that I just wrote almost all of.

And plus I'm pretty sure I said I got the info from a lot of different sources.
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I can say that I got information on the flying spaghetti monster that lives in the sky from a lot of different sources but until I share those sources that information means nothing
 
Many opioids are more than opioids, buprenorphine, tapentadol, tramadol, even oxy is not well defined to this day, methadone and tramadol are also nmda antagonists...absolutely possible fór buprenorphine i just don't know why bupe and tram wd's are like a curse from deepest hell, i could quit hydromorphone 97%pure Powder from pill factory habit (smoked) in grams but can't quit fucking tramadol for 11 years
 
Y'all about to get really mad, because Diphenhydramine increases GABA, and 200-400mg of Diphenhydramine is give, or take 1 to 2mg of Xanax.

IM NOT SAYING ANY OF THIS IS FOR SURE, BUT IM ABOUT/AROUND 97 percent sure at least.
 
WellTram said:
Many opioids are more than opioids, buprenorphine, tapentadol, tramadol, even oxy is not well defined to this day, methadone and tramadol are also nmda antagonists...absolutely possible fór buprenorphine i just don't know why bupe and tram wd's are like a curse from deepest hell, i could quit hydromorphone 97%pure Powder from pill factory habit (smoked) in grams but can't quit fucking tramadol for 11 years
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Yes Buprenorohine is a stronger NMDA antagonist than DXM.

AGAIN AROUND 97 PERCENT IS HOW SURE I AM.
 
And Buprenorphine may also increase serotonin on the 2a like psychedelics.

It is an antagonist of this Histamine 1 receptor, works on TAAR1 and more.
 
I am Also on benzos for 10+years, 2mg xanax i took 2 hours ago is just my maintanence dose for not seize of oxy and tram i took before 3 hours...but 200-400mg DPH will Kick my ass, like 10mg xanax
 
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