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Drug designs. (MedicinalUser SAR thread)

(RS)-N-phenyl-1-phenylpropan-2-amine ? That's a real simple stimulant.

If anyone has any ideas for a new drug go ahead and post it. Especially if you think it's a 5-HT2a super agonist.
 
I call this one Super-Tryp. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N-(2,4-dimethylazetidine)-(2,4-dimethylazetidine)-(2,4-dimethylazetidine)-(2,4-dimethylazetidine)-N-[(2,3-dibromo-1,4,5,8-tetramethoxy-naphthalene)methyl]tryptamine.
 
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I call this one Redux. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N-[(2,4-dimethylazetidine)-(2,3-dibromo-1,4,5,8-tetramethoxy-naphthalene)methyl]tryptamine.
 
What would you think if some one came up with Super X ? Such as... 6,7-Methylenedioxy-naphthalene-N-methyl-2-propan-2-amine. Do you think it would work ?
 
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I call this one Methyl-Methoxy-6. Its molecular structure is 2,3,4,5,6-pentamethoxy-N-methyl-1-phenylmethoxyethan-1-amine.
 
I call this one Blender. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N-[(2,4-dimethylazetidine)-(2,3-furan-5,6-furan-phenyl)-(2,3-dibromo-1,4,5,8-tetramethoxy-naphthalene)methyl]tryptamine.
 
MedicinalUser247 said:
What would you think if some one came up with Super X ? Such as... 6,7-Methylenedioxy-naphthalene-N-methyl-1-propan-2-amine. Do you think it would work ?
Click to expand...

NG-55
6-(2-Aminopropyl)naphthalen-2-ol, PC20541918.
Niko Gert Gubernator, et al. WO2008013997 (2012 to Columbia University of New York).

NG-50 (6-Methoxy-2-naphthyl)-2-aminopropane, Naproxfetamin.
pubchem.ncbi.nlm.nih.gov

(6-Methoxy-2-naphthyl)-2-aminopropane

(6-Methoxy-2-naphthyl)-2-aminopropane | C14H17NO | CID 18070083 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
 
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Smyth2 said:
NG-55
6-(2-Aminopropyl)naphthalen-2-ol, PC20541918.
Niko Gert Gubernator, et al. WO2008013997 (2012 to Columbia University of New York).

NG-50 (6-Methoxy-2-naphthyl)-2-aminopropane, Naproxfetamin.
pubchem.ncbi.nlm.nih.gov

(6-Methoxy-2-naphthyl)-2-aminopropane

(6-Methoxy-2-naphthyl)-2-aminopropane | C14H17NO | CID 18070083 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
Click to expand...
Well it's similar, but not the same.
 
I call this one Phish. It's molecular structure is 2,5-dimethoxy-3,4-dibromo-1,6-cyclopropane-phenyl-(2,4-dimethylazetidine)-methanamine.
 
MedicinalUser247 said:
Well it's similar, but not the same.
Click to expand...
These compounds have the same aryl group so a proven pharmacophoric building block:

NS9775
6-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)naphthalen-2-ol.HCl
Fb: PC11499781 HCl: PC67403453

Andreasen, Jesper T.; Redrobe, John P.; Nielsen, Elsebet Ø.; Christensen, Jeppe K.; Olsen, Gunnar M.; Peters, Dan (2013). "A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances". Neuropharmacology. 73: 183–191. doi:10.1016/j.neuropharm.2013.04.060.

Also see WF-33
en.wikipedia.org

2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane - Wikipedia

en.wikipedia.org en.wikipedia.org

I doubt that any of your compounds actually fit the receptors and are almost impossible to make for mostly all of them.

I'm not sure the software you are using but chemdraw is unable to recognize most of the names you are using.
 
I call this one Easy-Rider. Its molecular structure is 6,7-methylenedioxy-1,4,5,8-tetramethoxy-naphthalene-N-[(2,4-dimethylazetidine)methyl]-2-propan-2-amine.
 
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I call this one Jingle-Bells. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N1-(2,4-dimethylazetidine)-N2-(2,4-dimethylazetidine)tryptamine.
 
I call this one Hells-Bells. Its molecular structure is 1-isopropyl-4,5-dimethoxy-6-tribromomethyl-N1-(2,3-dimethylcyclopropane)-N2-(2,3-dimethylcyclopropane)tryptamine.
 
I call this one Puple-Rain. Its molecular structure is N,N-(2,4-dimethylazetidine)-3-(methyl(1,3,4,5-tetrahydrobenzo[c,d]indole-4-yl)amino)propanamide.
 
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