Basically tachycardia from two sources at once causes micro-tears in the aortic valves IIRC. Even exercise—which causes tachycardia—on a stimulant is rough on your heart. So, yes: coke, caffeine, meth, amphetamine, dexedrine, methedrine, Adderall, Vyvanse, Ritalin, substituted amphetamines and phenethylamines in general, plus: cathinones, pyrovalerones, benzodifurans, phentermines, phenidates, analogs of any and and all of the above, not to mention cardiovascular exercise, resistance training, aerobics, and sexual intercourse – any of these things, when combined, will make your heart explode in your chest immediately in an extremely dramatic, 'Hollywood heart attack fashion' immediately, no exceptions. Just one minute your heart is fine; the next minute? Fuckin' BLAMMO, kid. Stick a fork in ya – ya done, son.
(I'm exaggerating, obviously, but to be clear, mixing stims is bad for your heart, no question).
increased temp is neurotoxic but luckily I didn't do such comobos more than few times in my life.
Specifically the temperature of the head, and thus: the brain…
Many stim combos increase cardiotoxicity.
Virtually all, as I understand it. Stims pair well with GABA-ergics like benzos or GHB. Stims are terrible with psychedelics, not great with most dissos—Calvin Klein being the exception—mixed reactions when combined with Cannabis, and in general, aside from something to take the edge off, stims go best by themselves (or with a PDE5 inhibitor).
If one stim in combo is cardiotoxic you can bet that adding another will make it worse. Amphs and coke combo are likely in this category.
Absolutely, particularly since they cause CNS stimulation via two different mechanisms. Amphetamines are triple monoamine releasing agents. They release the presynaptic storage of dopamine, adrenaline and serotonin. However, cocaine acts as a triple monoamine reuptake inhibitor, so rather than causing the release of those three neurotransmitters, it blockades the reuptake process, allowing previously released dopamine, adrenaline & serotonin to stay longer in the synapse and increase their CNS stimulating effects.
I've seen people doing even coke + MDMA, another pointless and contraproductive combo
MDMA's action is precluded by 5-HT (serotonin) reuptake inhibition; e.g.: why SSRIs block MDMA's action. As discussed above, coke happens to be a reuptake inhibitor, so this checks out. Coke cancels out most of MDMA's effects.
but once you pop you can't stop, even if objectively you could have much nicer experience with one drug alone.
Idk what you're talking about here. Once you do coke and you're on MDMA, that's it. You ruined your roll and you won't be able to roll hard again for at least a couple days after the tolerance wears off. At that point, you might as well just do coke that night, since your MDMA is fucked off for the evening. Or just don't mix them. Most ppl figure that out after fucking it up once or twice. It's not hard to figure out. Also, an experience being pleasant or 'nice' is
inherently not an objective experience. It's pretty fundamentally subjective; just saying, though I'm splitting hairs and I do take your meaning and agree.
And best stim combo is no question, one with sex.
Hear, hear, good point. Now that I think of it, you're right; I do like to pair a stimulant with a PDE5 inhibitor like Cialis. Good times, had by all.
