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Cocaine like effects from Diphenhydramine?

plumbus-nine said:
Do you have a source for the claim that DPH was 1/10th of cocaine at the DAT?

But I guess even if true then it will be a silent antagonist at the DAT transporter instead of an inverse agonist like cocaine. Inverse agonists circumvent the autoreceptors which inevitably get activated with reuptake inhibition and strongly limit the amount of extra transporters released.
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No it's not a silent antagonist it blocks it's re-up take like Cocaine does. Cocaine actually is a deleriant, but less of one then Diphenhydramine. Diphenhydramine increases Serotonin, Norepinephrine, and Dopamine like Cocaine, but not as strong. Cocaine's chemical structure is pretty much the deleriant Scopolamine's chemical structure with one little thing added to it. It, and other deliriants like Chlorpheniramine have SNRI effects. More less SNDRI effects.
 
The Holy Quadruplty said:
Yea I heard about that. Can't wait to get my Promethazine's back just got to wake up at day time instead of night time so I can see my doctor. Then no more Diphenhydramine unless I ever end up not being to get them anymore. I take Chlorpheniramine everyday also.
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Promethazines dementia risk is just as high as benadryl. Chlorpheneraine also carries that risk. You are asking for memory problems with that amount of shit with benzos as well.
 
plumbus-nine said:
Do you have a source for the claim that DPH was 1/10th of cocaine at the DAT?

But I guess even if true then it will be a silent antagonist at the DAT transporter instead of an inverse agonist like cocaine. Inverse agonists circumvent the autoreceptors which inevitably get activated with reuptake inhibition and strongly limit the amount of extra transporters released. Like why SSRIs take 3-4 weeks to exhibit effects while cocaine or methylphenidate work instantly. But also cocaine's effects are a sum of norepinephrine, dopamine and serotonin, not just dopamine.
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I have no idea if this is true just something I thought about. Do you guys think that could be?

I have s theorynthat they only start working after so long is because they become addicted to it in those first few weeks so it's like getting a drug you're addicted to, and once you get it your depression anxiety goes away since you're still taking the SSRI if that makes any sense.
 
axe battler said:
Where's the source please @The Holy Quadruplty? Say a good like of coke is like 80mg, then you'd need to take 800mg to create the dopamine levels of 1 line, and by then at that dose, the other effects of dph would overwhelm the experience massively.
Maybe you could try it and let us know... If you can still type after 800mg of dph. On second thoughts, don't do that.
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Ok so I was on somewhere between 500 and 800mgs of Diphenhydramine earlier. So I decided to take another 800mg, and I've never done more than 300mgs that I can remember. It's been like half an hour ish since the extra 800mg, and I'm already hallucinating like crazy. I do feel pretty stimulated actually. Kind of resembles Coke with Ketamine, LSD, and a lot of Benzos. I don't know how I'm typing, but it's taking a real long time to type. Extremely hard to focus, but focusing... I can't type anymore right now I keep in forgetting what I'm trying to type before I'm half way done. I'll check back in here after like an hour goes by, and let you guys know how I feel.

Edit: It's been 30 seconds since I wrote that, but wanted to say that I have a 1mg blue Xanax I want to do since I feel so trippy, but I'ma ride it out as long as I can!
 
paranoid android said:
Promethazines dementia risk is just as high as benadryl. Chlorpheneraine also carries that risk. You are asking for memory problems with that amount of shit with benzos as well.
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I was just saying, because they are the real deal when it comes to The Holy Quadruplty drug cocktail. I'm just using Diphenhydramine for the time being, but still got the Chlorpheniramine.
 
I'm feeling even more euphoric, and don't want to stop typing. I don't think I've noticed this much of a stimulant effect from them, well atleast not this much maybe close.
I also keep seeing people like my mom walk by in the corner of my eyes as I'm typing this, but I'm the only one here. Lmfao I can see like people sitting on the other couch, and sounds like they're whispering. It's also very hard to concentrate even though I am feeling some stimulant effects as well, and ummm. Ok I'll be back. Lol
 
Yo dude just gonna say DPH is pretty bad news to use recreationally at higher than therapeutic doses especially long term

I even used to enjoy DPH probably more than a lot of people. Especially at low doses in combination with other drugs, but honestly if you aren't suffering from an immediately concerning allergic reaction there is no reason to use this drug.

It feels like it dries your brain up into a raisin and leaves you a weird shut in with paranoid delusions and an inability to stop taking dph. Its weirdly compulsive to dose it for some folks as strange as that may seem but honestly dude once you get some space from it you'll realize how absurd it was to take toxic doses of a common allergy medicine to achieve an objectively sub par buzz with moderate to long term negative effects/hangovers.
 
Update: So a grey hooded figure just crawled into my TV that's off, and was chilling there for a minute on the couches reflection off the TV to make it look like he was sitting on it inside my TV.

This just happened at 6:30pm
 
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FuckinAcidMan said:
but honestly dude once you get some space from it you'll realize how absurd it was to take toxic doses of a common allergy medicine to achieve an objectively sub par buzz with moderate to long term negative effects/hangovers.
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It's just another drug more so than just an Antihistamine for "Allergy Relief". LSD is an antihistamine, coke, and a lot of others!
 
Update: It's 9:48pm east coast time now, and I still feel very trippy. I feel even more euphoric than trippy tho especially since I took my hole 1mg of Xanax at the same time about half an hour ago instead of half earlier then half now. That's because I'm still awake from when I took the 4mg of Klonopin, and extra half a Xanax like 24 hours ago give, or take? I'm really stoned too from the weed, and just feel amazing. I got the craziest munchies, and going to eat after smoking this joint. Yea I saw figures walking around my house, and could here them talking to each other.

Dosages of drugs used:
I'm pretty sure (well not 100% sure about the actual dosage of Diphenhydramine atleast, and I know the rest of the dosages are correct, but it may have been 200mg of Doxylamine. Not less than 100mg of Doxylamine forsure) it was 1,600mg (1,300mg - 1,600mg) of Diphenhydramine, 100mg of Doxylamine, 4mg of Klonopin, 3.125mg of Xanax, 16mg of Subutex Sublingually in quarters at different times, Menthol Cigarettes, and very potent Marijuana. I'm bout to eat a lot of chocolate asap too so I'll be on Caffeine, and I prefer not to eat caffeine much, but I'm on enough downers that it shouldn't take away any downers effects which are my favorite!
 
1.6g of DPH is an epic dose for sure, and this with other stuff on top. Glad you're alright! Crazy you can still tell what is hallucinations and what reality, most people lose contact to reality from less diphenhydramine, at least according to the trip reports I've read.

The Holy Quadruplty said:
It's just another drug more so than just an Antihistamine for "Allergy Relief". LSD is an antihistamine, coke, and a lot of others!
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LSD and coke aren't antihistamines to my knowledge, the only recreational drug which has affinity for H1 is DXM afaik. But cocaine has structural similarities with stuff like atropine indeed and I think troparil is a delirant, maybe coke has antagonistic affinity to muscarinic receptors as well, would explain some things.

But a reuptake inhibitor is a 'silent' antagonist, in contrast to an inverse agonist. Or am I using this term wrongly?
 
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plumbus-nine said:
1.6g of DPH is an epic dose for sure, and this with other stuff on top. Glad you're alright! Crazy you can still tell what is hallucinations and what reality, most people lose contact to reality from less diphenhydramine, at least according to the trip reports I've read.


LSD and coke aren't antihistamines to my knowledge, the only recreational drug which has affinity for H1 is DXM afaik. But cocaine has structural similarities with stuff like atropine indeed and I think troparil is a delirant, maybe coke has antagonistic affinity to muscarinic receptors as well, would explain some things.

But a reuptake inhibitor is a 'silent' antagonist, in contrast to an inverse agonist. Or am I using this term wrongly?
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LSD definitely has affinity for the H1 receptor, and I'm pretty sure Coke does too. Subutex even has some affinity for it.
 
plumbus-nine said:
1.6g of DPH is an epic dose for sure, and this with other stuff on top. Glad you're alright! Crazy you can still tell what is hallucinations and what reality, most people lose contact to reality from less diphenhydramine, at least according to the trip reports I've read.


LSD and coke aren't antihistamines to my knowledge, the only recreational drug which has affinity for H1 is DXM afaik. But cocaine has structural similarities with stuff like atropine indeed and I think troparil is a delirant, maybe coke has antagonistic affinity to muscarinic receptors as well, would explain some things.

But a reuptake inhibitor is a 'silent' antagonist, in contrast to an inverse agonist. Or am I using this term wrongly?
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Inverse agonist have an opposite effect on the receptors the work on.
 
plumbus-nine said:
1.6g of DPH is an epic dose for sure, and this with other stuff on top. Glad you're alright! Crazy you can still tell what is hallucinations and what reality, most people lose contact to reality from less diphenhydramine, at least according to the trip reports I've read.
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Yea idk maybe it's because I've tripped so many times on so many different drugs, and took/take a lot of drugs in high doses as well for a long time. I've legit ate 20 Xanax bars at once, and was still able to keep my eyes open kind of. I needed help walking to the bathroom tho.
 
plumbus-nine said:
1.6g of DPH is an epic dose for sure, and this with other stuff on top. Glad you're alright! Crazy you can still tell what is hallucinations and what reality, most people lose contact to reality from less diphenhydramine, at least according to the trip reports I've read.


LSD and coke aren't antihistamines to my knowledge, the only recreational drug which has affinity for H1 is DXM afaik. But cocaine has structural similarities with stuff like atropine indeed and I think troparil is a delirant, maybe coke has antagonistic affinity to muscarinic receptors as well, would explain some things.

But a reuptake inhibitor is a 'silent' antagonist, in contrast to an inverse agonist. Or am I using this term wrongly?
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I'm aware DPH is a psychoactive drug, I have used/abused it myself. What I'm trying to communicate, I guess, is that DPH sucks.

It is a shitty drug with many unpleasant long lasting side effects and generally not something you wanna take absurd doses of to catch a buzz.

I'm glad you found a cheap drug to get high on and have learned it has a lot more activity than simple allergy relief. That does not mean it is a good idea to get high on it, it will rob you of your ability to interpret reality slowly but surely.

Please reconsider recreational use of diphenhydramine.

Especially in such high doses.

You are damaging yourself mate.

However, It's your life ultimately, I just felt I should give you a fair warning.
 
FuckinAcidMan said:
I'm aware DPH is a psychoactive drug, I have used/abused it myself. What I'm trying to communicate, I guess, is that DPH sucks.

It is a shitty drug with many unpleasant long lasting side effects and generally not something you wanna take absurd doses of to catch a buzz.

I'm glad you found a cheap drug to get high on and have learned it has a lot more activity than simple allergy relief. That does not mean it is a good idea to get high on it, it will rob you of your ability to interpret reality slowly but surely.

Please reconsider recreational use of diphenhydramine.

Especially in such high doses.

You are damaging yourself mate.

However, It's your life ultimately, I just felt I should give you a fair warning.
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I say this with love and support, I personally really enjoy DXM which is looked down on or considered dirty by a lot of people, but I personally enjoy it from time to time and my body and mind seem to tolerate it a lot better than others.

We are all built different and may have things we may enjoy that perplex others.

However I simply feel you should be informed about just how hard on your mind and body DPH can be especially at such notably high doses as the ones you are taking. I'm happy you are tolerating and even enjoying your deleriant experiences I just want you to be aware DPH is a deceptively relaxed poison that slowly adds many layers of long lasting mental fog and bodily irritation while making it harder for you to notice for yourself.

It's like quick sand. You just kinda sink into it slowly it's weird.
 
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