Hi there! I have tea with my grandmother now, and don’t really have time to get deeply involved with a long post, but I might help you better out later.
Recently some guy was asking something about dmt on discord and I gave him a long and good reply, only for him never to see it and I watched it go down the drain. So I screenshotted it and we’ll, I might just post what I wrote here now:
psyduck — 07/27/2022
I'm just confused about smoking it cuz it's not on crystal form and the all said that I have to use a jet lighter but mine will be a fine powder
And a crystal pipe too
[3:03 AM]
affa — 07/27/2022
5 meo dmt products are not similar, there are several formulations which differ so drastically, that questions regarding proper administration needs to be narrowed down to the given formulation in question.
How does the powder look, and smell? From what I gather by your way of talking, you are dealing with the most common type, which is extracted from seeds, typically the yopo-seeds, which are rich in 5-MeO-DMT.
PS: I saw you mentioning the term ‘’smoking.’’ 5-MeO-DMT cannot be smoked in this sense, you need to vaporize it. A common way of doing this is by putting the extract in a glass bottle with doble ventilation tubes at the cap and heating the underside of the bottle until the container is milky white. After this is done, all you need to do is keep sucking the straw till you fall backwards (preferably on pre-set soft pillows and mattresses…
[3:07 AM]
affa — 07/27/2022
Because it needs to be mentioned; Do NOT mix MAOI-inhibitors with 5meo-dmt as one could often think of with n,n-dmt, as in the case of changa or ayahuasca. This is very very dangerous, and you can risk actual death.
[3:38 AM]
affa — 07/27/2022
Below I cited a slice from available research concerning the issues regarding the combination of MAOI-inhibitors and 5-MeO-DMT:
''As a fast-acting drug, 5-MeO-DMT induces many physiological and behavioral changes in humans and animal models, such as visionary and auditory distortion, hyperthermia, head-twitch, and stimulus control, which involve the actions of 5-HT receptors.
It is readily inactivated through the MAO-A-mediated deamination pathway, while a small portion is transformed to the active metabolite bufotenine by polymorphic CYP2D6.
Receptor binding studies have revealed that 5-MeO-DMT is more selective for the 5-HT1A receptor, while bufotenine mainly acts as a 5-HT2A agonist.
The apparent non-selectivity of 5-MeO-DMT may be attributed, at least in part, to bufotenine produced from 5-MeO-DMT, which is dependent on CYP2D6 enzymatic activity.
5-MeO-DMT is often co-abused with an MAOI such as harmaline to enhance hallucinations.
There are two levels of interactions between harmaline and 5-MeO-DMT, pharmacokinetic and pharmacodynamic.
When deamination metabolism is inhibited by harmaline, the systemic and cerebral exposure to 5-MeO-DMT, as well as to the metabolite bufotenine, is sharply elevated and prolonged.
Meanwhile, harmaline and 5-MeO-DMT both act agonistically on the serotonergic systems. As a result, coadministration of harmaline potentiates 5-MeO-DMT drug responses and sometimes leads to severe or fatal serotonin toxicity in animal models.
Several cases of intoxication or even death have also been reported in humans associated with the abuse of 5-MeO-DMT and harmaline.
In addition, depending upon the dose combination, an influence of CYP2D6 genotype/phenotype on harmaline-5-MeO-DMT DDI may be seen, despite the fact that the CYP2D6 enzyme inactivates harmaline whereas it activates 5-MeO-DMT.
Therefore, CYP2D6 may serve as a marker for bufotenine production during pharmacokinetic interaction between 5-MeO-DMT and harmaline.''
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is ...
www.ncbi.nlm.nih.gov
Sourced of PubMed Central (PMC)
affa — 07/27/2022
In any case, it would really help your cause with some additional information, if you have it. The place that sold these substances, is there any potential information on anything other than ''synthetic 5meo-dmt''?
It’s always ''synthetic'' unless you eat the yopo seeds, or some of the other containing plants, but I don’t really recommend eating them due to toxic dosages of other stuff but either way: you prolly do got regular crystalline 5meo-dmt even though its more like a fine grounded powder, yeah.
affa — 07/27/2022
You don’t have to smoke it either. Snorting works great too. Apparently. I have never heard of anyone doing this other than reading about it though but be careful with dosages. From what my friends tell me, 5-meo-dmt can be in a way more intense in terms of bodily highs then the ''regular'' rubber smelling n,n-dmt.
affa — 07/27/2022
Also, to be honest- they have all said its scarier. But it’s hardly facts, just anecdotes. But I do remember how shulgin had this insane moment in thikal then he smoked 5meo- and called it horrible ruthless love, but scary and he kept screaming inside his head ''you killed yourself! you killed yourself!''. But I think there were nicer trips too. Like calm loving ones.
[4:12 AM]
affa — 07/27/2022
[Affa]
@Psyduck[/USER] -> info above
July 28, 2022
[4:12 AM]
rusin — 07/28/2022
yoo
July 29, 2022
WoahMan — 07/29/2022
Yo if i bought tabs that were 25
, my text don’t always come out what was going on in my mind at the time ,no offense was meant.