Jabberwocky
Frumious Bandersnatch
yeah man, like limonene... I believe is technically food safe but I also used it as a nonpolar acidic solvent to extract DMT. Pretty hardcore shit...
lots of pretty hardcore terpenes out there
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CD Moderators: someguyontheinternet
Delta 8 THC Megathread
- Thread starter Delsyd
- Start date
lots of pretty hardcore terpenes out there
MaBudd
Greenlighter
do not understand how they can have Sativa or Indica from Hemp ........ Can Not get any answers on that--
Jabberwocky
Frumious Bandersnatch
Marketing.
They take the terpenes from various strains and add them back into d8
It's just the same d8 but will taste like indica or sativa, no difference in effects.
thegreenhand
Bluelight Crew
Fwiw I’ve seen some delta8 being sold with sizable quantities of CBD and CBG added.
While I don’t subscribe to the indica/sativa dichotomy sufficient concentrations of those may impact the effects, but admittedly not greatly if at all
w01fg4ng
Bluelighter
A senator says delta 8 makes you a rapist and compares d8 to PCP and flaka.
so - here is the best write up on the pharmacology of minor hemp noids I've ever seen - https://www.frontiersin.org/article...dJ7sQf2-06PNjmk9Mq9Cld97aRznwzkP4hwllpQL9sy2k
TRPv differences are facilitating the release of different neurotransmitters downstream, including GABA and endogenous opioids -- IMO this is why we see such differences in the different noids "more pain relief, more anxiety relieving" etc.
also, I just went through a benzo withdrawal. If I spend even a couple of days dabbing d8 I begin to develop GABA withdrawal symptoms, complete with shakiness, tachycardia and nervousness. It goes away pretty easily, but it's a thing.
**edit** another paper about mu/trp interaction : https://www.pnas.org/content/pnas/114/51/13561.full.pdf
also interesting to note -- FULL ON synthetic CB1 agonists are causing death by GABA blockade. I was helping the research side of some people trying to get together a good protocol for emergency admissions re synth noids.
ativan + CBD ( I am urging them to add CBG, but it has no FDA approval
only known tolerated CB1 antagonist) is what was finally decided on.. they are having seizures/multi-organ failure/hyperthermia from complete glutamate overload and GABA shutdown. not a great way to go.
CBG is also a triple reuptake inhibitor at GABA/DOP/NOR. Fascinating stuff in the noid world. I also feel like it's one of the best mental health meds I've ever taken.
TRPv differences are facilitating the release of different neurotransmitters downstream, including GABA and endogenous opioids -- IMO this is why we see such differences in the different noids "more pain relief, more anxiety relieving" etc.
also, I just went through a benzo withdrawal. If I spend even a couple of days dabbing d8 I begin to develop GABA withdrawal symptoms, complete with shakiness, tachycardia and nervousness. It goes away pretty easily, but it's a thing.
**edit** another paper about mu/trp interaction : https://www.pnas.org/content/pnas/114/51/13561.full.pdf
also interesting to note -- FULL ON synthetic CB1 agonists are causing death by GABA blockade. I was helping the research side of some people trying to get together a good protocol for emergency admissions re synth noids.
ativan + CBD ( I am urging them to add CBG, but it has no FDA approval
only known tolerated CB1 antagonist) is what was finally decided on.. they are having seizures/multi-organ failure/hyperthermia from complete glutamate overload and GABA shutdown. not a great way to go.CBG is also a triple reuptake inhibitor at GABA/DOP/NOR. Fascinating stuff in the noid world. I also feel like it's one of the best mental health meds I've ever taken.
Jabberwocky
Frumious Bandersnatch
yeah, THC has an antagonistic function at GABA especially at higher doses
went thru a benzo withdrawal few months ago myself and the first thing I did was put down the d8 for that reason
this is part of the reason it can produce anxiety in a lot of people
That’s the interesting thing/thing about trp pathways and noids —- d8 was fine for me in benzo wd, d9 intolerable. And I get withdrawal from d8. Also - my sleep depth etc totally changes with d8 in a way that only gaba agonists produce in me. Took some last night and my watch is like “what did you do??! Your sleep was amazing!” — now I use it about twice a month just to catch up on sleep.
Jabberwocky
Frumious Bandersnatch
yeah d8 has a lot less anxiety to d9, likely simply due to it's decreased psychoactive potency
they both effect me nearly the same in every way other than reduced anxiety/psychedelic properties in d8
I’d agree except for the withdrawal which definitely does not occur for me w d9. Even equalized dosages I get much less anxiety and most especially electrical tics which are extremely indicative to me that my gaba signaling is having an issue.
I’d agree except for the withdrawal which definitely does not occur for me w d9. Even equalized dosages I get much less anxiety and most especially electrical tics which are extremely indicative to me that my gaba signaling is having an issue. Eager to see more research in these areas speculating is useless ;/
Jabberwocky
Frumious Bandersnatch
I'm part of the camp which believes about 98% of cannabinoid (natural) withdrawal is psychological. It's weird and mostly psychological IMO.
I mean I certainly have lack of appetite, but the dysphoria of cannabis withdrawal has always been in my mind. If I'm motivated to quit it never comes and it feels like nothing - if I run out of weed and want more the psychological withdrawal and anhedonia can be very strong, but always ultimately in my mind.
Personally, I don't think cannabis has a physical withdrawal, but I'm not denying that it can't be absolutely awful at times.
I'm also comparing to heroin/fentanyl/benzo/alcohol withdrawal which might not be the fairest comparison.
To be clear - I experience 0 physiological withdrawal from normal plant extract in high doses, dabs all day, 10g plus weed a day. The only thing that has brought this on was a few stints vaping pure delta 8. I 100% agree outside of less appetite, hard to sleep a few nights d9 and whole plant extract have 0 wd. Why I was shocked when d8 put me in such a weird way. Imo the different sub noids have pretty distinct pharmacological properties. I could always be wrong but the trp research seems to support at least differing downstream modulation effects (which might be all it takes)
Jabberwocky
Frumious Bandersnatch
interesting
personally I've always experienced more of a withdrawal from cannabis/d9 compared to d8-THC
but this is all highly subjective and anecdotal with many other things going on in my life at the time
Likewise. Could be down to individual brain chemistry or also - unknown contaminants in the unregulated hemp noid supply. Just found a thc-p pen at head shop and bought it impulsively… not sure if I should hit it
Jabberwocky
Frumious Bandersnatch
I love it. If you have any amount of tolerance it won't be overly intense. Those carts in the stores arent super strong but definitely get you high. Just found a thc-p pen at head shop and bought it impulsively… not sure if I should hit it
w01fg4ng
Bluelighter
w01fg4ng
Bluelighter
I've let my tolerance get out of hand several times doing over a gram a day for weeks on end. I've been able to quit for a few days at a time without much issue. I use about a gram of CBD for each day I'm not using and it relieves the majority of my sleeping and anxiety issues making it easy to fall asleep without THC.
I'm not sure how long some of the withdrawals might last as I haven't tested those waters yet. So far they seem as benign or more benign than delta 9.
I'm not sure how long some of the withdrawals might last as I haven't tested those waters yet. So far they seem as benign or more benign than delta 9.
Innerpeace
Bluelighter
- Joined
- Nov 15, 2012
- Messages
- 930
Does Delta 8 have potent antiinflammatory effects like Delta 9?
Delsyd
Bluelight Crew
I believe it does since it works great for pain.