I got this Accord DHC, sent it to Wedinos and it came back legit:
Can you suggest what dose of DHC combined with Clonazepam or Xanax might give a nice nod? But I know I need to be careful with that combo.
I took 180mg DHC by itself and got nothig from it
How much opiate tolerance do you have mate? If you have a low tolerance you should have got something from 180mg even if it's just feeling itchy.
If you have no tolerance and get no effect I'd guess you have a lack of CYP2D6 and/or CYP3A4 enzymes which are required for both codeine and DHC to metabolise.
Instead of mixing benzos and opiates, have a small dose of promethazine (10mg or so) and some grapefruit while dosing your DHC and have 240mg. If you get nothing from that, it just won't work for you.
But to explain my logic here: promethazine potentiates opiates and is said to increase the amount of codeine metabolised into morphine so the same should apply to DHC's metabolites since they both rely on CYP2D6 (DHC only partially, but still). Grapefruit as you probably know interacts with a lot of drugs by acting heavily on the CYP3A4 enzyme and mildly on CYP2D6. It is known to potentiate the effects of most opiates. You want to have the grapefruit after the DHC because grapefruit is an inhibitor, so having it before DHC would stop it from metabolising at all, while having it after should potentiate the metabolites already in your body.
Benzos are unlikely to make any difference since unless your problem is tolerance, it sounds like you are just not metabolising the DHC and benzos won't change that.
So all actavis pills have changed to accord? I'm in the UK
Yes. Some pharmacies might still have old Actavis branded stock lying around but once that's gone any new shipments will be Accord branded from now on.
The short version of the story behind this is Teva bought Actavis but couldn't keep Actavis UK due to competition law - it would have given Teva a huge monopoly over the UK generics market. So Teva was forced to sell Actavis UK and sold it to Intas, an Indian pharma company. They have a UK subsidiary called Accord and over the past few years have been merging Actavis into Accord. This process is now complete, so any new blisters will now carry the Accord brand.
You might also see Almus branded boxes containing Accord branded blisters. This is perfectly normal, Almus is a company previously owned by Actavis UK now owned by Accord.