Rectal 1P-LSD?

[methoxetaman]

Does rectal 1P-LSD work? Since it’s said to be a prodrug, the “1P” part gets removed—where does this happen? Stomach? Liver? By the saliva?

Has anyone tried rectal administration? Is it weaker?

I ask because I recently got some blotter that was said to be LSD.

I’ve plugged up to four doses with minimal effects. I tripped, but it was weak and short-lived. Like an LSD-ultra-light.

My friend also tried them, sublingually, and said they’re weak but def “did the trick.”

Also, the source got all upset when I said it was weak and insists that I “just do it too much.”

That was the first time I’ve taken it (or any serotonergic psych) for quite a while. I’m talking years.

I am wondering if maybe I was given 1P or another analogue, and by plugging it, reduced the effects.

 

[donvliet]

I don’t know. Are you on any meds? Some can greatly deminish the effects of psychs.

 

[F.U.B.A.R.]

Yeh, the 1p bit is removed through liver metabolism so oral is the most effective way.

 

[methoxetaman]

I don’t know. Are you on any meds? Some can greatly deminish the effects of psychs.

Yes, but none that would diminish the effects. I have already done my research regarding this. Thanks

 

[methoxetaman]

Yeh, the 1p bit is removed through liver metabolism so oral is the most effective way.

I am going to try a few sublingually, soon, and see if my results are better.

 

[F.U.B.A.R.]

Sublingual will also bypass the liver - it needs to be in your stomach. Why not just eat the stuff?

 

[methoxetaman]

Ok yeah I realized that after I said it.

I suppose I’ll try that, but I’ve heard swallowing normal acid and is weaker than sublingual.... but this probably isn’t acid anyway so yeah. I guess I’ll try swallowing a couple on an empty stomach.

 

[F.U.B.A.R.]

Ok yeah I realized that after I said it.

I suppose I’ll try that, but I’ve heard swallowing normal acid and is weaker than sublingual.... but this probably isn’t acid anyway so yeah. I guess I’ll try swallowing a couple on an empty stomach.

Yeh, normal acid just needs to get into your bloodstream, so the quicker it can do that the more effective it will be. But 1p-LSD has to be converted to LSD by first pass liver metabolism via the hepatic portal vein from the stomach. Therefore, any other ROA will not be as effective as just swallowing it.

Have fun :D

 

[methoxetaman]

Yeh, normal acid just needs to get into your bloodstream, so the quicker it can do that the more effective it will be. But 1p-LSD has to be converted to LSD by first pass liver metabolism via the hepatic portal vein from the stomach. Therefore, any other ROA will not be as effective as just swallowing it.

Have fun :D

well, I will try swallowed soon.
Though, I did experience some effect from rectal.

Does this mean even rectally-administered drugs end up getting metabolized, somewhat, in the liver? Just not as efficiently/much as when swallowed?

or that 1P is active on its own?
Again, I don’t know for sure this is 1P, but I’m sure plenty of people have taken 1P sublingually and experienced a trip.
Or else I think I would have heard people reporting that it didn’t work sublingually. Which I haven’t.

 

[F.U.B.A.R.]

The problem with bypassing first pass metabolism is that some of the pro drug will be excreted by the kidneys before it gets back round to the liver for conversion. There will still be some effect from other ROAs, but not as much...

 

[AutoTripper]

Even if it was an equally effective and efficient ROA, with lysergamides, I really don't think it will make any difference at all in terms of potency in fact I think there is a chance you will lose more of it and absorb less in the first place to gain nothing.

 

[Chris Timothy]

Lower the pH of your plugsel.

 

[methoxetaman]

Even if it was an equally effective and efficient ROA, with lysergamides, I really don't think it will make any difference at all in terms of potency in fact I think there is a chance you will lose more of it and absorb less in the first place to gain nothing.

I was under the impression that sublingual bioavailability is around 71%, while rectal is closer to 100%.

I have heard numerous people claim is it stronger for them rectally.

Why would I not absorb all of it, when done correctly? As in dissolved in distilled water and the bowels/rectum is empty and clean...

 

[methoxetaman]

Do you think my rectum is acidic and degraded the dose or what?

 

[Chris Timothy]

If you add an acidic compound to it, it's like treating the rectum like a stomach.

Can't go overboard with it for obvious reasons, but I do add some citric acid to some dissociatives before plugging sometimes, for instance.

 

[methoxetaman]

Hmm. Interested. And my bad I was Prly high and mixed up the pH scale (thinking high means acidic but it’s the other way around).

do you think it could help if I just added a drop or two of Citric acid to the boof solution? Or is that what you meant?

 

[F.U.B.A.R.]

Hmm. Interested. And my bad I was Prly high and mixed up the pH scale (thinking high means acidic but it’s the other way around).

do you think it could help if I just added a drop or two of Citric acid to the boof solution? Or is that what you meant?

Just neck the fucker. Why are you so obsessed with shoving it up your arse when you already know it wont be as effective as it would be if it was just plain old LSD?

Freud would have a lot to say about you my friend...


Adjusting the pH of the solution isn't going to alter the fact that you've bypassed first pass metabolism...

 

[PriestTheyCalledHim]

Ok yeah I realized that after I said it.

I suppose I’ll try that, but I’ve heard swallowing normal acid and is weaker than sublingual.... but this probably isn’t acid anyway so yeah. I guess I’ll try swallowing a couple on an empty stomach.

No LSD is not more strong if you keep it on your tongue, put it in your eyes, versus swallowing. Dosage or the ug/mics determines strength of LSD, not route or method of ingestion.

You might as well just swallow the research chemical instead of spanking your ass, and then probing and exploring your asshole to take the research chemical via boofing, plugging, or by putting it up your ass via finger or enema.

 

[AutoTripper]

No LSD is not more strong if you keep it on your tongue, put it in your eyes, versus swallowing. Dosage or the ug/mics determines strength of LSD, not route or method of ingestion.

You might as well just swallow the research chemical instead of spanking your ass, and then probing and exploring your asshole to take the research chemical via boofing, plugging, or by putting it up your ass via finger or enema.

I have to strongly disagree with you on the eye route. I put tabs in my eye several times, and no no question at all- a lot stronger, but more in a "jarring" way than transcendental if that makes any sense.

I can't speak for plugging, and I agree it makes unnotuceable difference under tongue or swallowed.

 

[PriestTheyCalledHim]

I have to strongly disagree with you on the eye route. I put tabs in my eye several times, and no no question at all- a lot stronger, but more in a "jarring" way than transcendental if that makes any sense.

I can't speak for plugging, and I agree it makes unnotuceable difference under tongue or swallowed.

That is the placebo effect.

Putting blotter paper in your eye is a good way to damage your eye either temporarily, or permanently.