Liver/kidney damage related to melanotan use?

JohnBoy2000

JohnBoy2000

Bluelighter
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May 11, 2016
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There seems to be outlying case reports of individuals who get extreme results over prolonged or excessive use of MT2.

Feedback around here has always been it being very safe it.

Liver/kidney damage, I understand it can happen with steroid use but, MT2?

Anything to report?
 
JohnBoy2000 said:
There seems to be outlying case reports of individuals who get extreme results over prolonged or excessive use of MT2.

Feedback around here has always been it being very safe it.

Liver/kidney damage, I understand it can happen with steroid use but, MT2?

Anything to report?
Click to expand...
I've never had bad blood work with it. Even at 5mg/week.
 
Now that I think about it, I've ran it at 1mg/day over a month and had no issues. The clinical trials they did in Australia used huge doses over long periods of time and I don't believe they had any issues other than cosmetics lol
 
“prolonged or excessive use”....so how about we don’t use it excessively for prolonged periods lol
 
LadyAlkaline said:
🤣 pardon me, I'm a bit daft. Thanks for the clarification.
Click to expand...

Haha that's funny you say that, I actually made the same mistake a few times. I was like wait melatonin can help you tan better? 😂 Then I went on to see that Melanotan was what a lot of bodybuilders use to get that bronze, heavily tanned type skin look.

So don't worry I made the same mistake haha
 
Serotonin101 said:
Now that I think about it, I've ran it at 1mg/day over a month and had no issues. The clinical trials they did in Australia used huge doses over long periods of time and I don't believe they had any issues other than cosmetics lol
Click to expand...

Any links to those trials?
 
JohnBoy2000 said:
Any links to those trials?
Click to expand...
pubmed.ncbi.nlm.nih.gov

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study - PubMed

A pilot phase I study was conducted with a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). The lactam-bridged molecule, called Melanotan-II (MT-II), has the structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2 (MT-II) and has superpotent...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
This is just what came up. I couldn't find the one I was thinking of what showed a white Australian man becoming essentially aboriginal in appearance lol
 
This is a very recent case report regarding kidney damage after melanotan 2 use
pubmed.ncbi.nlm.nih.gov

Melanotan II: a possible cause of renal infarction: review of the literature and case report - PubMed

Renal infarction is an uncommon condition resulting from an acute disruption of renal blood flow and it is potentially life-threatening disease. The cause and outcome of renal infarction is not well established and is frequently misdiagnosed or diagnosed late. Melanotan II is a non-selective...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

It makes a reference to previous renal failure cases, wasn't able to find them though. Couple of mentions of rhabdomyolyis, as far as I can tell all by injecting. Wondering wether the nasal spray is perhaps less damaging considering people report less side effects using it that way.
 
I used this drug a while back very consistently and after a while used to experience cramping around the solar plexus area for a few minutes after an injection.

Couldn't explain it really.

I took a break and recently started MT2 again but not so much cramping this time around.
Perhaps it will escalate over time?

I couldn't explain it at the time but, I mean the area of cramping is/was suspiciously around the kidneys.

Kidney function tests may reveal something?


I think this is the full paper of that linked above:

Melanotan II: a possible cause of renal infarction: review of the literature and case report - PMC

Renal infarction is an uncommon condition resulting from an acute disruption of renal blood flow and it is potentially life-threatening disease. The cause and outcome of renal infarction is not well established and is frequently misdiagnosed or ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Not sure if I'm reading that correct but did the dude inject a full 10 mg at one time?

It alludes to uncommon reporting of such effects but hints they're probably attributable to MT2 in this case.

Maybe sustained/prolonged use?
Who knows?

That solar plexus cramping I experienced was a concern, it only emerged after using it every day for an entire summer.
Then took a break and restarted, now absent.
 
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