Tagamet for both adderall and Klonipin potentiation

[HeirCroc]

I've done a lot of research in the past few months on reducing tolerance to Adderall, ways to mitigate neurotoxicity, and ways to potentiate Adderall. I know far less about Kpins, but I plan to use Tagamet to potentiate it in the near future. I realized, however, that Tagamet is an antacid and therefore should, in theory, potentiate the Adderall. What do you all think, will it work for both purposes? If so, how long before dosing (I take addy first then kpin a couple hours later) should I take Tagamet/how much Tagamet?

As I've researched the Adderall stuff, I've added supplements to my regiment. I currently use turmeric containing bioperine, tums (occasionally), magnesium chelate, and zinc, all after I ingest Adderall (except for tums), and melatonin at night. I just ordered some vitamin D or C (can't remember which heh). First, should I be taking the turmeric, etc, before I ingest Adderall? Second, will any of these supps interfere with the functioning of the klonipin or create a dangerous combination?

Thanks for your time. This is a great forum.

 

[Keif' Richards]

Be aware that there are a few different mechanisms at play, but in a simple way, yes, both of these substances can potentiate the subjective effects of both Amphetamine and Clonazepam (Klonopin, Rivotril). Amphetamines and their duration of effect are highly augmented by the relative PH of the urine. In essence, any substance that increases urinary PH or, in other words, makes it more basic, is going to contribute to a longer duration of effect from Amphetamines. Cimetidine is not required for this purpose. Tums or Sodium Bicarbonate (Baking Soda) are both going to be just as effective and less expensive.

Clonazepam is not a Benzodiazepine that can be tweaked with a great level of efficiency by inhibiting liver enzymes. There are other drugs that will be potentiated to a modest degree by Cimetidine, but even those that are well-known to be potentiated i.e. Methadone, are still nothing to write home about. You'd be better off using the money on more drugs. If, for instance, you were dealing with a drug that requires a lot of metabolism to various active substances, like Chlordiazepoxide (Librium) or Diazepam (Valium), you would have a better chance at actually experiencing a beneficial potentiation. In my opinion, still not remotely worth the time or effort.

In short, you can definitely toy with duration of Amphetamine intoxication by playing with your urinary PH, but it's pretty much pointless to do so with the Clonazepam.

 

[HeirCroc]

Thanks for the input. Do you have an opinion regarding the other supps I take/the order of ingestion? In particular, I can't find a consensus about when to take the turmeric, magnesium chelate, and zinc--before, during, or after ingestion of the amphetamines.

Thanks.

 

[Pilll_head]

Tagamet is most effective on drugs that have a short half life, like opioids and the stuff mentioned above by Keif. Clonazepam has both high oral bioavailability and a really long half life so you aren't going to notice much of a difference from Tagamet. Tagamet's inhibition of the liver enzymes increases the amount of drug in your bloodstream, but this isn't really the same as potentiation. Potentiation is more like the effect of GABA agonists on opioids or the combo of alcohol with benzos (neither of which I recommend BTW unless you know what you are doing)

 

[Keif' Richards]

Thanks for the input. Do you have an opinion regarding the other supps I take/the order of ingestion? In particular, I can't find a consensus about when to take the turmeric, magnesium chelate, and zinc--before, during, or after ingestion of the amphetamines.

Thanks.

Essentially, before is the most practical option. You need to make your stomach and urine as basic as possible. That is not to say though, that you can't continually adjust your urinary PH for the duration of the effect. I will typically do a baking soda antacid maybe two or three times during an Amphetamine experience and I would venture to say that if done correctly, basifying the urinary PH both before and during the experience can extend the duration significantly.

I'm going to include a study conducted a while back that is available freely on PubMed. This article highlights and more or less proves the veracity of everything that I've been discussing here. In short, Basic Urinary PH = Longer Duration.

https://www.ncbi.nlm.nih.gov/pubmed/18481797