Albeit not in book form, but I've tried. And I'm not convinced I've ever managed it. I'm always having to figure out how to rework things for digestion by other subjects. One of theses days I'll end up with an aneurysm the size of a melon
It appears 3,6-dibutyrylmorphine takes a long long time to come on. The longest out of all the morphine diesters I've tried.
A carboxylate group takes the formula R-COOH where R is an alkyl, alkenyl, alkynyl chain, which formerly bore a hydroxyl group, R-OH, or a phenol/amine to give phenolic esters or amides respectively. The simplest carboxylic acid, formic acid, R is simply H, the formula for formic acid being HCOOH, one more methylene unit, (this being formally derived from methane, CH4, having lost one atom of hydrogen gives CH3COOH, acetic acid, and so on and so forth, with each carboxylic acid going from formyl, through acetyl, propionyl [3] to butyryl [4, derived from the 4-carbon alkane, butane)
What I was trying to say, was that going from morphine, and forming a carboxylic (di)ester, in the case of a reagent for acetylation, at least, the anhydrides or combination of acyl halide and base the result would be heroin, in the case of the next largest simple, small molecule (I mean, a length of a handful or so of carbon atoms making up the acyl [acyl, is what we term the fundamental carboxylic 'unit', and adding one of these, either to an alcohol, or phenol [something with an -OH group connected to a carbon, in the case of an alcohol, this is a straight or branched chain of carbon atoms, or a non-aromatic ring. An aromatic ring, in the case of a benzene ring gives one a phenol. These behave in many ways like alcohols in that they can be acylated, alkylated, form ethers, thioethers etc. although phenols are much much more acidic than alcohols, for example, cyclohexanol isn't particularly acidic, whilst the aromatic homolog of cyclohexanol would be phenol.
And phenol itself is quite capable of burning human skin, one of my science teachers, before she knew that, burnt herself with it actually, she once told me) But in many ways, they do follow similar types of reaction patterns that alcohols do. In the case of an amine group, and an acylating reagent, the result is an amide. For example, 1 mole of ethylamine would give 1mol. acetamide upon reaction with 1 moles of acetic anhydride [this isn't synth discussion, its not psychoactive, I'm just explaining the fundamentals using simple, uncomplicated reactions, along with, as the anhydride reacts, an equimolar quantity of acetic acid. Half the molar quantity of an acid anhydride reacts by acylating a suitable substrate, whereas with the other common form of activated acyl species, an acyl halide, the result is an equimolar ratio of acylating species and the byproduct is a hydrohalic acid, E.g carboxylic acid chlorides, in the case of formation of acetamide from ethylamine would release an equimolar amount of hydrogen chloride, which generally means a base has to be present to absorb it as its released.)
Anyhow, 3,6-di(n)-butyrylmorphine (butyryl being the acyl group containing a 4-carbon chain, the one after propionyl, from propionic acid, which has three, acetic acid has two and formic, one. Although conditions for formylations are generally somewhat different)
Seems much as expected, with certain surprises thrown into the mix. Now I'm not certain it was a direct response, but it turns out that I ended up with quite a boner...unexpected considering there was no company, and no sexual setting. It appeared to be a mechanical response if that makes sense. Still present upon going to sleep and waking up. And it turns out that butyrate is a vasodilator, working by activation of the niacin receptor causing blood vessels to widen. And whilst there was no sexual content to this, opioids generally block testosterone release and cause a loss of sexual interest. In any case I was alone, with nobody present to be interested IN regardless, so it wasn't the setting, or the set. I think it may well have been the dibutyrylmorphine.
Slow to act (given by IM injection, approximately -180-210mg (forgot somewhere along the lines of this investigation 30mg either way. My apologies.), it took what seemed like an age, perhaps 10 minutes to begin to be felt properly, and as long as another 15-20 to feel as though it was doing as much as at the dose tested it was going to do. No rush, although from an IM I didn't expect one. A lot less histamine release than morphine sulfate but I would say more than heroin and approximately akin to dipropionylmorphine. Which is an awful lot stronger, faster acting and euphoric than di-(n)butyrylmorphine. The latter did however, seem to last still longer than H, I just topped up with some morphine sulfate, although not withdrawing, (at around half 3 PM, the dibutyrylmorphine taken early in the morning at least 13-15 hours or so, that was beginning to tail off.)
The main difference was what I believe might have been the..ahem...response, to the vasodilatory effect. It did feel a little warmer than I'd have expected from its level of opiate potency. Not euphoric, but more heating, akin to a niacin flush, although I don't know if I LOOKED flushed or not in the face, it was dark, and I had shades on, for reasons I don't need to go into here.