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Phenethylamines Self experiments with new series of NXXX-phenylethylamines

Hans Meyer said:
thank you solipsis! that is a very interesting point of view!
If I understand you right, the meO- is transformed to HO- by the first liver pass, or is it completely removed to H- ?
So the 5-OH derivates shoud be systemically (oral) potent?
The sublingual administration isn´t fine, only a workaraound. Some compounds need several mg, something to much for sublingual admin.

Also thanks for the opsin-link, lateron I will try; now I am in a hurry.
Hans
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The MeO- is very rapidly metabolized to HO- which in turn is very rapidly glucuronidated i.e. phase 2 metabolism sticking hydrophilic groups like glucuronic acid on it.
 
Solipsis said:
The MeO- is very rapidly metabolized to HO- which in turn is very rapidly glucuronidated i.e. phase 2 metabolism sticking hydrophilic groups like glucuronic acid on it.
Click to expand...
Thanks Solipsis for that very important info. The group at 5-position is the central problem!

I started to make 2-methoxy-4,5-methylenedioxy-pheny-derivatives. They don´t have the 5-CH3O-group. But needs some time.
 
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sensitivity of 2CX-NBX

;)
Hans Meyer said:
Thanks Solipsis for that very important info. The group at 5-position is the central problem!
Click to expand...

Hi Solipsis! Is it realy the OCH3 at position 5, not at position 2? In the 2CX-part or in the NBX-part or in both?
And I learned that benzylic-N is sensitive for both: reductive and oxydative fission. Ok you can not compare that with biochemical enzymatic fission. Greatings Hans;)
 
Hans Meyer said:
;)

Hi Solipsis! Is it realy the OCH3 at position 5, not at position 2? In the 2CX-part or in the NBX-part or in both?
And I learned that benzylic-N is sensitive for both: reductive and oxydative fission. Ok you can not compare that with biochemical enzymatic fission. Greatings Hans;)
Click to expand...

Yeah, it's explained here: https://www.youtube.com/watch?v=AmuuS4gxOVc ... one of the methoxies in the 2C-X part, not the 2' position or anythiing.

You may be interested to hear that 2C-B-FLY-NBOMe has been synthesized so I am personally wondering if that is reliably orally active since it should be resistant to this metabolism. And no: enzymatic cleavage is quite different from reaction conditions. Stability during storage / exposure to normal atmosphere, and stability under physiological conditions should be the ones to count. Also potentially under different pH conditions when the gastrointestinal tract is concerned.

Hans Meyer said:
Hallo Solipsis,
I am so sorry, but I don´t understand, how to insert the structure, given by http://opsin.ch.cam.ac.uk/
when insert the IUPAC name. Greatings Hans
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1. Generate Opsin structure image from formula name.
2. Rightclick on the generated image and choose "copy image URL" --> it will copy the URL to your clipboard i.e. it will be remembered
3a. Use this code in a post here in bluelight and paste the copied address instead of the '$imageURL$' by rightclicking and pasting or using CTRL+V if using windows:

Code: 
[img]$imageURL$[/img]

or alternatively 3b: use the 'insert image' function when editing your post and enter the Opsin image URL. It is one of the symbols, the third from the right, when editing your post.

I have no idea if they store them indefinitely or what.
 
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Thanks a lot, Solipsis, for that particularized informations.
I will answer lateron, for I need time to understand it fully.
greatings hans
 
I've added this to the Index as it represents a significant work that outlines novel substances that, to my knowledge, have not been tested/reported on anywhere else. Shame Hans was never able to work up to full dosages, on account of concern for his health, but even so, this is gold, thanks for bumping it cj. :)
 
Holy shit yeah. Hans' work here is up there with the likes of Alexander Shulgin.

Great stuff. Truly pioneering.
 
I suspect that this Hans meyer guy has access to substances from the German authorities aka bka.
 
This is such a classic thread!

I dont know if anyone can help me but I've been searching for a similar shulginesque document, detailing experiences concerning the amphetamine derivatives of eugenol and similar phenylpropene compounds. It wasnt nearly as groundbreaking as Hans work, but still interesting nonetheless...
 
In case you are still searching, you probably mean the work by the user "Demonic" from the Hyperlab. I think their work on "POMA" (3-MeO-4-PrO-A) is uploaded to isomerdesign under that name. He made many other interesting compounds, some other "eugenoloids" too. POMA itself I have tried up to 200 or even 250 mg, and I did not find it as interesting Demonic. Qualitative effects didn't change much between 120 mg and the higher doses so I assume receptor efficacy is lacking to develop full psychedelic effects. I certainly had characteristic alerts such as yawning, the phenethylamine head tingles, etc. But the mental state was essentially just a bit of confusion developing to nothing tangible, and I did not find it to be moodlifting or fun. But neither did it have any strong side effects.

While Hans work was certainly interesting, the lack of analysis is of course a negative (although I do trust that he was likely successful in most of his efforts) and the fact that he ever only assayed low dosages certainly amplified the influence of placebo. Demonic provided analytical data and dosed high enough for proper evaluation.
 
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