• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
EP-11 said:
9LeH0vw.png
What would this be like
Click to expand...

Looks like it would be a dopamine agonist like Pramipexole or a serotonin agonist, or maybe just inactive. But those are my best guesses
 
It'll migrate over to the nitrogen, form an imine, and be hydrolyzed to a ketone by water.
 
Nagelfar said:
Give me a stability lesson with this; which nitrogens are possible with it still being stable:

Z53dKT.jpg
Click to expand...

http://blogs.sciencemag.org/pipelin...wont_work_with_azidoazide_azides_more_or_less

IMO get rid of that 4th nitrogen in a row, the one connected to the azide. I don't think an azide can be connected to it, would want to start splitting off N2 instead of binding that way. It would go diazonium compound + say NaN3 --> organic azide + N2.

Not so sure about that other nitrogen in the ring either, those 3 in a row... don't know what that would do, I wonder if that N=N will want to be a triple bond if it gets a chance.
 
Last edited:
Dresden said:
It'll migrate over to the nitrogen, form an imine, and be hydrolyzed to a ketone by water.
Click to expand...
I am not sure if I get what you saying but I have the impression you may be talking enamines which are indeed not stable in water and will get hydrolyzed quickly to the corresponding ketone and amines. In enamines, the N is connected directly to the sp2 carbon to give vinyl amines which are not stable. But these are allyl amines(not vinyl).. they should be fine. Unless there is something specific about these particular compounds!
Actually, some of these have been published:
imgsrv.fcgi


https://pubchem.ncbi.nlm.nih.gov/compound/11008589#section=Top
Interesting thing: they are no releasers but pure Reuptake inhbitor. Unlike other stims they do not get transporter to storage vesicles. I think profile should be much closer to coke than anything... but who knows?
Title: Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors.

Abstract: A series of 3-amino-2-phenylpropene (APP) derivatives have been synthesized and characterized as novel competitive inhibitors, with K(i) values in the microM range, for the bovine chromaffin granule membrane monoamine transporter(s) (bVMAT). Although, these inhibitors are structurally similar to the bVMAT substrate tyramine, none of them were measurably transported into the granule. Structure-activity studies have revealed that, while the 3'- or 4'-OH groups on the aromatic ring enhance the inhibition potency, Me or OMe groups in these positions reduce the inhibition potency. Halogen substitution on the 4'-position of the aromatic ring causes gradual increase of the inhibition potency parallel to the electron donor ability of the halogen. Substituents on the NH(2) as well as on the 3-position of the alkyl chain reduce the inhibition potency. Comparative structure-activity analyses of APP derivatives with tyramine and the neurotoxin 1-methyl-4-phenylpyridinium suggest that the flexibility of the side chain and the relative orientation of the NH(2) group may be critical for the efficient transport of the substrate through the bVMAT. Comparable bVMAT affinities of these inhibitors to that of DA and other pharmacologically active amines suggest that they are suitable for the structure-activity and mechanistic studies of monoamine transporters and may also be useful in modeling the mechanism of action of amphetamine-related derivatives. https://pubchem.ncbi.nlm.nih.gov/bioassay/216244#section=Top
Click to expand...
 
The double bond is definitely going to switch back and forth to the enamine position and from there to a lesser extent to the imine, but if you've seen published reports of such compounds, then I must be wrong.

As far as the thing Nagelfar drew, I have never seen four nitrogens in a row, heard of a name for it, or can think of a synthesis that would accomplish it. That tells me it's probably not going to exist.
 
cLQAdU.jpg


Singh's phenyltropane "41b" (16 ± 2 @ DAT) + para-pos.-subst. –C≡C-CH2Ph (1.82 ± 0.42 @ DAT) + 84p/(CH2)4Pht (2.38 ± 0.22 @ DAT) + C1 phenyl (32.3 ± 5.7 @ DAT cf. 326 ± 106 of parent compound)
 
Bagseed said:
the carbon connected directly to the amine is sp3. the double bond cannot go there.
Click to expand...

double bond can migrate there in acidic condition, styrene-type structure is very easy to get protonated,
after protonation and de-protonation, db has 2 site to go, one to original, other to the enamine.
 
If it were a pyrollidine rather than a pyrroline, this would be a 2-benzylpyrrolidine, which are covered in this 1981 patent: US 4279918 2-(Nuclearly-substituted)benzylpyrrolidines. The methylenedioxy isn't mentioned specifically, but in general the compounds in the patent have a variety of stimulant, analgesic and hypotensive effects, so it's probably active.
 
Pomzazed said:
double bond can migrate there in acidic condition, styrene-type structure is very easy to get protonated,
after protonation and de-protonation, db has 2 site to go, one to original, other to the enamine.
Click to expand...
I am not sure that I follow... you mean that the benzylic carbon will be protonated I guess? but how will that turn the sp3 carbon at the 2-position if the butane chain into sp2. can you clarify the mechanism?
 
Frogs have cloacae, not penises.

And that phenyltropane monstrosity thingy, bet thats a buggering twatting shitbox to synthesize haha. And that terminal pthalimide would likely come off in the stomach if orally taken, pthalimidopropiophenones can be used as cathinone prodrugs this way for cathinone (this was an israeli popular drug iirc, pthalimidopropiophenone) and SOMEONE has ambitions of seeing it done with psychedelic cathinones to stabilize them.

The benzyamine would possibly be an MAO(a)I, alpha-methylbenzylamine is.

You don't want to be tasting that azido thingy either. Azido functionality can make for irreversible (covalent binding) ligands. No thanks.
 
Heh if it were pramipexole-like that wouldn't be a bad thing. Pramipexole is lovely stuff, and damn does it ever take a sledgehammer to the male refractory period! plus you can watch porn with dogs mounting and shagging girls doggy style, missionary style any style a dog will to do a girl, believe me, see it and you'll watch it for hours on pramipexole. And get off repeatedly every minute or two.

Plus its pretty much nice, added as an adjunct to morphine, or dipropionylmorphine or both mixed together, even nicer with a wee dash o'clonidine added to it before banging the mixture. Wouldn't mind trying pramipexole/clonidine/morphine sulfate/dipropionylmorphine/dibenzoylmorphine with cyclizine though too. Haven't done that yet though because whilst I've a lot OF it, I have only cyclizine hydrochloride, of which the solubility can suck the ballsack of the same dogs that I yanked off for about 8 hours straight that time I accidentally came (see what I did there) upon that video of the blonde girl of about 17yo wearing the dog collar with the golden retriever. Plus a whole bunch of ugly ones who if they did appear in porn I would not be interested in even ON pramipexole, like pitbulls, mastiffs, bulldogs or those tiny yappy little shithead anklebiters that posh twats like to take for 'walkies' in their prada cunting well handbags, the vapid islamonecropaedophile theresa-may-worshippers.

Just need to get round to basing the cyclizine and forming a soluble salt.

Anyone know how the phosphate or citrate salt do? or the ascorbate? I KNOW the lactate is, but rather not buy something I'll rarely ever use otherwise (the lactic anhydride/lactyl chloride)
 
Status
Not open for further replies.
Top