N&PD Moderators: Skorpio | thegreenhand
We all know what fen-phen did to folks till 90s. A lot of other drugs activate 5-ht2b. Which ones would cause most damage if used excessively?
i.e. micro dosing on LSD daily? Rolling every weekend? Taking 4-fa?
Pretty much all psychedelics are strong 5-HT2B agonists. Yet we don't hear about heart valve toxicity in (ex)-hippies or heavy psych users in general.
Serotonin itself is obviously a full agonist of that receptors, yet we don't hear about heart valve toxicity in SSRI users for example either.
Not even in e-tards, although these obviously have a ton of other problems.
So..who knows? It seems to be a bit more complex than simple receptor agonism.
Pretty much all psychedelics are strong 5-HT2B agonists. Yet we don't hear about heart valve toxicity in (ex)-hippies or heavy psych users in general.
Serotonin itself is obviously a full agonist of that receptors, yet we don't hear about heart valve toxicity in SSRI users for example either.
Not even in e-tards, although these obviously have a ton of other problems.
So..who knows? It seems to be a bit more complex than simple receptor agonism.
Loss of serotonin 5-HT2B receptor function may predispose to fenfluramine-associated PPH in man.
http://cardiovascres.oxfordjournals.org/content/60/3/518.long
That mutation was only found in 1 of the 10 ex-fenfluramine users suffering from PPH, so their conclusion
is eh rather questionable.
Pretty much all psychedelics are strong 5-HT2B agonists. Yet we don't hear about heart valve toxicity in (ex)-hippies or heavy psych users in general.
Serotonin itself is obviously a full agonist of that receptors, yet we don't hear about heart valve toxicity in SSRI users for example either.
Not even in e-tards, although these obviously have a ton of other problems.
So..who knows? It seems to be a bit more complex than simple receptor agonism.
shugenja find the paper or stfu seriously
etards dont take e everyday which explains why they dont have any issues this is a chronic problem so that is absolutely no proof mdma wont cause this toxic issue.
Yeah i tought it was low, never really researched it while i was taking 5 meo dalt daily, i never had the impression there was a big risk with all the ppl taking low daily treshold doses of psychedelics. Still figuring out how this occurs would be worthwhile tough as psychedelics would work for atypical depression, in contrast to sero antagonists working for melancholic. atleast the succes rate of mirtazepine is pretty much the sae as ssris, same as placebo, which doesnt mean they dont work as placebo peters out after 6 months and ppl often report poop out after 5 years, eg placebo is noise covering up the true therapeutic effect, which is still neglible.
Also with regards to therapeutic use of sero releasers we are talking like 30mg of mdai 3 times a day or so.
Less 5-HT2b activation would mean less damage, so maybe, broadly speaking, the more other serotonin sites that a 5-HT2b agonist hits, the more is displaced from 5-HT2b.