I didn't mean to imply the secondary sources were de facto shitty, just that AutSqueaks are really really not to be trusted in and of themselves. One of the most repugnant, ginormous bunch of utter fetid smegma-gargling dicknibblers ever to have befouled the air the rest of us have, regrettably, to share with the bastards. I just felt it needed pointing out that they are not in the slightest above spewing out hateful, billious pseudoscientific quackery and crap. Behaving as though they are a supportive and beneficient organization who care about autistic people is utterly reprehensible, disgusting behavior when what they REALLY want, is to see a world where we are all detected as foetuses and aborted accordingly, as happened, sickeningly, and still happens to could-have-been people with down syndrome. AutSqueaks would just LOVE to be able to have a part in prenatal testing, and thus making it possible for doctors, midwives etc. to pressure mothers to abort us. Quite frankly the thought makes me sick to my stomach. Not to mention furious, for it (prenatal testing for autism) is an abomination, and a thing which should not be.
Its one thing to be able to diagnose such things as Tay-Sachs, batten disease and other such lysosomal storage diseases, and ensure that such foetuses do not come to term. Those with incurable and utterly terrible diseases that result in a short life
of nothing but suffering and misery before death eventually, mercifully supervenes. But quite another when who is to be born, are people like us, and like those with Down syndrome, who indeed I am perfectly happy to call kin, despite their not being on the autism spectrum (as a result of the trisomy that is). Its something like 80%+ of down syndrome babies who are killed before they have the chance to be born. And minus sometimes physical complications like holes in the heart it doesn't mean a lifetime of misery and suffering FOR THE PERSON BORN, and quite frankly, if the only 'suffering' is due to a parent or parents feeling like they didn't get the perfect baby they were owed by god, or nature or whatever else, then thats their problem, it should never be ours. And in any case, they are mistaken, and probably not less for being exposed to the putrid muck espoused by Autism Squeaks
What should we on the spectrum expect, if there is such an abhorrent monstrosity as prenatal testing for autism (WHY precisely? because it cannot, and should not, be changed if detected, so the only reason possible, is to make abortion easier. It certainly is not and won't be something capable of benefiting US. Its for the parents, not for the gestating person-in-potentiae. If there is misery, its because it is being heaped upon heads, the owners of which are told they are somehow less than perfect, whole, decent, equal human beings. And that disgusts me beyond words, as it should, and when we get the chance to learn of the wider autistic community, it does, every last single autie, the aspies and the one girl with Rett's that I know, we ALL are pissed off and none of us that I know of, bar perhaps 3-4 exceptions TOTAL, over the entire time I have been active online as a member of the various spesh folk forums, the ones run for and importantly IMO, also BY us, have agreed with AutSqueaks, that we are damaged beings etc, etc. And those people who have, seem to have had that message inculcated in to them by parents and family, which cannot but help destroy people's self-esteem, and for no possible benefit in so doing.
The rest of us, whilst yes, its true that being autistic can come with challenges and some uncomfortable crap (such as, for example, when my old man wipes down the lightweight portable table that sits before my mother's wheelchair so she can eat etc., the texture of the surface is such that he now warns me he is going to do it, so I can jam a finger in each ear, or take it as a cue to leave the room and have a cigarette in the kitchen, and he's gotten a plastic/rubberized large spoon for cooking, when things like baking are on the agenda, because I cannot abide the repulsive coarse-grained texture of that particular wood on my fingers. Just like I have to, if ever I buy myself, or am bought, an ice-cream that comes on a stick, hold it in the packaging, wrapped round the stick, because the texture goes right through me, like notes from an out of tune violin with rusty strings, played by means of a bow strung with the rotting hide of a terminally diseased puff adder)
And yes, I take meds, some of which are for that reason, well one of them is, some are for other things but act similarly, and or have improved various bits and pieces as a side benefit. I take clonidine to prevent my overloading and it works very well for me. Thats the only one I take specifically for the explicit purpose of anything autie-related, but other stuff I'm on may as well be for it, in some respects, like the chlormethiazole I'm on for seizure prophylaxis, unrelated to autism, true enough but it does do a mighty fine job of combating difficulty getting to sleep, which is damn common in autistic people and aspies. Don't know about Rett girls, because I only know the one (lovely girl....not to mention hawt
) but thats a respective sample of one, and as such not at all representative. Especially since shes a chimaera and as such, quite atypically expressive of Rett's.
Question is, is the source of the 5HT external to the BBB or otherwise, talking about the biosynthesis of the high blood levels of 5HT, is it peripheral AND central, or solely peripheral? 5HT doesn't cross the BBB if administered peripherally, so what
conclusions can be drawn solely from blood 5HT levels, are probably not of great importance to whats going on in the CNS. But of course that is making the assumption that the peripheral high levels don't also exist at similarly high concentrations (the CNS equivalent thereof, that is) on the other side of the BBB fence.
Haven't yet read the studies, will do though now.
More effective SERT would lead to less stimulation of presynaptic 5HT1a autoreceptors, and thus increased levels of 5HT released into synapses to compensate, would it not? does it also result in increased biosynthesis (in autistic subjects that is)
probably somewhat difficult to just pop in and take a look, seeing as how we are as unwilling as anybody else to have our heads cut open and microdialysis probes
