2C-B Effects on Serotonin and MDMA?

[Jabberwocky]

Registered May 2015........... Sorry brotha. Dont come in here spreading mis-information. This drug WILL fuck you up if you dont follow basic HR with it. Dont roll multiple days, and take proper breaks between rolls. This isnt a game. The thing about its affects, most people dont notice them until they wonder why they hate everyone and everything.

I was on the old forum, probably when you were in elementary school -- brotha

 

[Black]

serotonin depletion is a myth -- else 2-CB. LSD, etc would not work after using MDMA

vitamin c easily crosses the BBB

6 grams per day of vitamin c is easily taken orally without causing diarrhea

psychedelics are partial agonists at serotonin receptors. since they elicit a response themselves and are not releasers like mdma they are not affected by serotonin depletion.

where have you got that 6g figure? i know of doses of ascorbic acid of 250mg/kg (Gudelsky 1996) rescuing from mdma neurotoxicity. 250mg/kg is almost 17.5g for your average 70kg human. wikipedia states that side effects like diarrhea start occurring with single dosages above 3g, which is pretty much what i remember the threshold to be.

 

[Jabberwocky]

psychedelics are partial agonists at serotonin receptors. since they elicit a response themselves and are not releasers like mdma they are not affected by serotonin depletion.

where have you got that 6g figure? i know of doses of ascorbic acid of 250mg/kg (Gudelsky 1996) rescuing from mdma neurotoxicity. 250mg/kg is almost 17.5g for your average 70kg human. wikipedia states that side effects like diarrhea start occurring with single dosages above 3g, which is pretty much what i remember the threshold to be.

I regularly consume 6-12 grams of ascorbate salts or ascorbic acid daily when ill. Take a 16 ounce bottle of water and dissolve 3 grams C into the bottle -- 2 -4 ounces every 15-30 minutes will not cause diarrhea - easily drink 2, 3 , 4 bottles throughout the day

The secret is frequent smaller doses (2 ounces = 375 mg 4 ounces = 750 mg)

the 250 mg/kg of C was protective against a 20 mg/kg injection

I propose that 50 or even 25 mg/kg is protective for normal recreational oral doses