• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids IV Loperamide experiment [Experience incoming over the night, progressive]

dopemaster said:
Lopermide [...] doesn't cross the bbb.
Click to expand...
That is incorrect Information. A lot of scientific articles claim this, but it only rings true for low doses. I will post sources later, eventhough personal experience of countless individuals like me should be proof enough and imho even count for more. Loperamide makes me nod to the point I Fall asleep mid-sentence. Again and again.

englandgz74 said:
Your an idiot.
Click to expand...
Said the guy who can't tell the difference between 'you are' and 'your' sigh.
 
Last edited:
Ok well it doesn't cross mine at least not worth a damn.

It can take away the sickness which is good enough sometimes so I suppose you are right to some degree cuz if I take it when I am sick I feel better so like not being sick is a buzz to me at this point in life.
 
crOOk said:
Said the guy who can't tell the difference between 'you are' and 'your' sigh.
Click to expand...

On the scale of idiocy I think that rediculous shit you posted above just about nudges ahead of a typo.
 
dopemaster said:
Ok well it doesn't cross mine at least not worth a damn.

It can take away the sickness which is good enough sometimes so I suppose you are right to some degree cuz if I take it when I am sick I feel better so like not being sick is a buzz to me at this point in life.
Click to expand...
Seems to vary a great deal between individuals. Central effects are still not some exotic rarity. Have you ever taken north of 50mg? Constipation won't get any worse in my experience, there seems to be a ceiling dose for that. I feel central effects starting at 20mg orally albeit very weak ones and go full-on nod at around 100mg.
 
Loperamide does cross the BBB, but it gets pumped back by P-glycoproteins.
Some people may have less P-glycoproteins than others, so I guess some might feel central effects from it.
 
englandgz74 said:
@chase_in_56ace .....exactly mate.

What amazes me is that some people are more worried about hurting the OPs feelings that condeming the rediculous nature of the experiment.

The fact that people may or may not have done foolish things themselves isnt really the point. I'm not sure why we're still discussing this TBH......
Click to expand...

I don't know about us being worried about OP's feelings, but I don't think it's right to ridicule someone regardless of how stupid you think they are. Personally, I think I read way unhealthier, dumber things on BL everyday, but people are much slower to ridicule simply because they're more common problems. Ya, OP probably didn't get anything out of IVing lope, and the risks had to outweigh the benefits. But in all seriousness, how many posts do you guys see where people are talking/asking about things they're doing or planning to do that aren't kind of stupid and risky? It seems to be a common theme IMHO

I just don't think it's ever right to pass your judgement and determine someone's action was stupid enough to deserve ridicule. It certainly doesn't solve any problems.
 
kleinerkiffer said:
Loperamide does cross the BBB, but it gets pumped back by P-glycoproteins.
Some people may have less P-glycoproteins than others, so I guess some might feel central effects from it.
Click to expand...
Exactly. I used quinine to inhibit PGP.


Well said Slow_Mobius.
 
Everyone who has been name calling or belittling others in this thread needs to reevaluate why they are on Bluelight in the first place. You are all missing the point. Is it safe? No. Is it intelligent? No. Is it even remotely advisable? No, but we need to be able to discuss these things without people worrying about being flamed off the forum. If everyone is too afraid to post, we won't have any information to work with.

That's the problem with this thread. I've said it already, but wouldn't you rather know if something terrible happens to this guy, or do you think it's better to not document the results. I guarantee you I'm not sitting, waiting to find out if this guy got a rush or not, I'm wanting to know if there are any health complications arising directly from the practice. I would never inject Loperamide, but not because it's unsafe, because I am pretty certain it wouldn't get me high.

We need to be welcoming and non-judgmental.
 
kleinerkiffer said:
I guess everyone assumed you didn't use a pgp and meant it can cross the BBB on its own
Click to expand...
Oh I've done it plenty of times without inhibiting P-Glycoproteine. In fact, it didn't add that much to the high to be honest. The only reason I don't do Loperamide on a regular basis is because it is expensive as hell if I bu OTC stuff. Other than that, I'd prefer it over a lot of other opiates (e.g. morphine really doesn't do all that much for me in terms of sedation and yes, I've dosed it very high many times). I have a very unusual body chemistry, but feel free to call bullshit on it anyway.

Keif' Richards said:
Everyone who has been name calling or belittling others in this thread needs to reevaluate why they are on Bluelight in the first place. You are all missing the point. Is it safe? No. Is it intelligent? No. Is it even remotely advisable? No, but we need to be able to discuss these things without people worrying about being flamed off the forum. If everyone is too afraid to post, we won't have any information to work with.
Click to expand...
Well said and Very very true. This happens a lot when it comes to OTC drugs.

chase_in_56ace said:
A part of me is seriously disappointed in humanity when I seriously contemplate the fact that we are having a discussion about IV lope. In all seriousness, I'm sure the consequences of administering a dose of lope in this absurd fashion would bring on disastrous results. Lets not and say we did.
Click to expand...
Now what would make you so "sure" of that? I have done it plenty of times and never experienced any adverse effects. By the way, the constipation is just as worse on other opiates, significantly worse even on some. Loperamide is the first-line treatment for IBS, but we still resort to Laudanum for the worst cases. Simply because it's more effective in that respect.

Regarding m IV doses... I'm pretty sure I injected over 40mg in single shots, but it's been a couple of years - My old posts will tell you more about it. It surely isn't safe, but I never experienced any ill effects, except for the usual opie sides.


EDIT: Word of warning, in case anyone gets the idea to use quinine to inhibit P-Glycoproteine. It is cardiotoxic and just because it is OTC in a lot of countries doesn't mean it's harmless. The therapeutic range is relatively narrow (meaning the distance between the effective and the lethal dose). Read up on it before you use it or ideally don't use it at all! It has recently been rescheduled in Germany and is not available over the counter anymore as far as I know (haven't checked that information myself) due to a few people having died from using it.
 
Last edited:
Ha they even quoted us.

Crook your doing no good advocating getting high on something so dangerous.
 
"They call it the poor man’s methadone."

Not in the UK they don't.......it's around $5.25 for 6 pills of brand name loperamide!! (around $1.50 for 6 of the generic).
 
englandgz74 said:
[MENTION=163795]chase_in_56ace[/MENTION] .....exactly mate.

What amazes me is that some people are more worried about hurting the OPs feelings that condeming the rediculous nature of the experiment.

The fact that people may or may not have done foolish things themselves isnt really the point. I'm not sure why we're still discussing this TBH......
Click to expand...
englandgz74 said:
"They call it the poor man’s methadone."

Not in the UK they don't.......it's around $5.25 for 6 pills of brand name loperamide!! (around $1.50 for 6 of the generic).
Click to expand...

Thats crazy I had no idea lope was that expensive over there. Anyone else thinks its an eerie coincidence that after this little gem of a thread gets going that article comes out? I'm sure its not absolutely directly our fault but Im saying we are the biggest drug discussion board around... Weird..


Anyway guys I'm on my way back form work. Made good money today and shot some great dope. What more can a man ask for? Say nope to lope and have a great day bluelighters
 
Heh... All I know is that for myself, I wouldn't attempt doing this unless I knew the substance involved was 100% water soluble, then it may cross my mind. But as for now it's too cloudy of an issue for me. So I don't foresee it in the near future whatsoever.

I must admit that I am curious on mega-dosing , but I have GI problems and irregular heartbeat as it is, so I don't see trying this out in my near future either.

I like what was said though, with drugs there always has to be that one person who is willing to "take one for the team". I always thought about who actually had the balls to be the first one to smoke that leaf, or eat that pill, or inject that substance, having no idea what the results will be. But there is always that first person who actually does it.

I hope this wasn't an incident of a troll enticing folks to try doing this. But I for one would like to know what happens.
 
englandgz74 said:
"They call it the poor man’s methadone."

Not in the UK they don't.......it's around $5.25 for 6 pills of brand name loperamide!! (around $1.50 for 6 of the generic).
Click to expand...


Same with the US.

Most drug addicts/drug users are smarter than those who write articles... the wit of some journalists is mind-blowing.
 
tacodude said:
Crook your doing no good advocating getting high on something so dangerous.
Click to expand...

At least someone agrees with me. :)

Seriously though if some folk who think that waiting for the OP to report back on how effective this was and getting all worked up about hurting his feelings had ever had to push on a 17 year old's chest so hard that they break his ribs and tell his distraught parents that their child is dead through a silly misadventure (as I have) them they may have a different outlook....

Just saying....
 
You must log in or register to reply here.
Top