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2C-B Effects on Serotonin and MDMA?

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itsallaboutjimmy

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Joined
May 8, 2016
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Hey guys, I am going to a 3 day EDM festival and am planning on hitting coke and lucy on the first night, its a combo thats worked well for me and that will be my first night.

Second night, I am considering trying 2C-B for the first time, I have rolled many times before but never done 2C-B, my only worry is if I do 2C-B on the second night, it might effect my molly roll on the 3rd night....

In a perfect world MDMA would work 100% day after day and I could have it every damn night. Unfortunately when I was a young rookie I took molly 2 days straight and it was a horrible experience and the come down lasted 4 weeks + so I wont be making that mistake again. I'm just wondering if anyone knows if the 2C-B may drain my serotonin levels and effect my roll/increase the recovery time of the MDMA? Or is 2C-B the perfect solution to this problem?

Also, would be taking a small dose of acid (50mcg) with 2C-B be a good combo??

Any experience or 3 Day festival wisdom would be amazing!

Thanks a lot!
 
2cb does not affect, it works! Im on the same plan, besides the coke and lucy idea.......... 3 day fest, day one, edible and few drinks, day 2 2cb (its fuckin awesome if you get the real deal, its rare though) then the full blown roll 3rd day. Gonna be a party!

If you havent ever done 2c-b id not mix it with anything. Feel it out alone. Its like the fun stuff of mdma and mushrooms in a pill. You'll get it. I can also tell you this, 2c-b is not draining at all. I usually dont feel as if i did anything the next day. :)
 
epic11 said:
Im on the same plan, besides the coke and lucy idea.......... 3 day fest,
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Awesome, your not going to EDC are you?:D

What dose do you recommend for that kind of enviroment? I've never had it at all before but I've heard it can make you feel pretty sick and give you gut trouble? Should I not worry about that?

Would 20mg be a decent dose? I want only a slight triping effect to enhance colours, i want to be able to navigate the stages, hear the music for what it actually is LOL and feel energized and buzzy like MD with a touch of psychedelic effects coming through? Is 2C-B the jackpot for this?
 
Yeh vitamine C works a charm with Molly...problem is the even goes for 3 days so there would only be 1 day break at most...3 days between rolls could be possible but really struggle with 1. Do you take vit C with the actual capsule or hours before?? When do you recommend dropping the vit C?
 
nau5ea said:
If you're like just about every other person who loves MDMA, you should read this https://www.erowid.org/chemicals/mdma/mdma_article3.shtml Erowid article about antioxidants and MDMA. The first time I tried taking vitamin C with my MDMA it worked quite well, and I was able to roll twice with only three days separation.
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NO. JUST NO. Its not about "can i roll" Its more about "what invisible damage have i done?" Next thing you know you are depressed....... for a year or longer. Dont fuck with this drug. It will embarrass you.

Golden rule, wait 3+ months between rolls and DO NOT BREAK THIS. Seriously......... Dont say i didnt warn you. I never abused it and still went through a depression that was horrible. Ive come to realize that 1 month wait is not long enough. This shit is powerful.
 
itsallaboutjimmy said:
Awesome, your not going to EDC are you?:D

What dose do you recommend for that kind of enviroment? I've never had it at all before but I've heard it can make you feel pretty sick and give you gut trouble? Should I not worry about that?

Would 20mg be a decent dose? I want only a slight triping effect to enhance colours, i want to be able to navigate the stages, hear the music for what it actually is LOL and feel energized and buzzy like MD with a touch of psychedelic effects coming through? Is 2C-B the jackpot for this?
Click to expand...

md dose 100-120 depending on your experience. Try 110?

2c-b dose. Still learning this one, but If you havent done it before. Try 22mg. It varies greatly from mg to mg. I personally like 25. Be aware of what salt you have as well. Its its HCL go ahead and weigh exact. If its hbr weigh it 3mg over your dose to nail it. Difference in salts.

Edit: No event names.
 
epic11 said:
NO. JUST NO. Its not about "can i roll" Its more about "what invisible damage have i done?" Next thing you know you are depressed....... for a year or longer. Dont fuck with this drug. It will embarrass you.

Golden rule, wait 3+ months between rolls and DO NOT BREAK THIS. Seriously......... Dont say i didnt warn you. I never abused it and still went through a depression that was horrible. Ive come to realize that 1 month wait is not long enough. This shit is powerful.
Click to expand...

but you see... the point of the antioxidant is to prevent against the "invisible damage." so when I say I took my vitamin C, I mean I solved the problem, to the best of my understanding. it's a whole other story if you actively attempted to neutralize any free radicals running about in your neurons.
 
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As an official old fucker,(for this forum) I consumed a decent bit of MDMA 10 years ago, along with several friends..we are all fine n ow. A couple friends chose to take it every week, for a few years straight, they all have persisting mood disorders, but whos to say that it was caused by MDMA.. I guess my point is, just like with vitamin C thing, is we are all guinea pigs here, and no one's really gonna know aht does what, and what damamges what, until this drug has exisited for more than a hundred years.. Hell, alcohol has been consummed for over 4,000 and the scientific community still isnt sure where the line should be drawn

I will say there are tons of formers ravers from the 80's and 90s out there, who consummed absurd amounts of MDMA, who have normal lives now..So if I had to guess, either the damaage is extremely long term(think 80 year old former raver), extremely short term(think the week after dosing), or non existant.
 
nau5ea said:
but you see... the point of the antioxidant is to prevent against the "invisible damage." so when I say I took my vitamin C, I mean I solved the problem, to the best of my understanding. it's a whole other story if you actively attempted to neutralize any free radicals running about in your neurons.
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No amount of vitamin C can negate what it does. Thats just sheer ignorance my friend. Yea, im sure it can help to an extent, but in the end. MDMA will fuck you up no matter what you do if you abuse it.
 
epic11 said:
No amount of vitamin C can negate what it does. Thats just sheer ignorance my friend. Yea, im sure it can help to an extent, but in the end. MDMA will fuck you up no matter what you do if you abuse it.
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I ask you for a source, not because I doubt you, but because I've been looking for more information about the antioxidant + MDMA interaction.
 
epic11 said:
NO. JUST NO. Its not about "can i roll" Its more about "what invisible damage have i done?" Next thing you know you are depressed....... for a year or longer. Dont fuck with this drug. It will embarrass you.

Golden rule, wait 3+ months between rolls and DO NOT BREAK THIS. Seriously......... Dont say i didnt warn you. I never abused it and still went through a depression that was horrible. Ive come to realize that 1 month wait is not long enough. This shit is powerful.
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1. All evidence of potential neurotoxicity in animals was eliminated when antioxidants are co-administered with MDMA.

2. There ARE many people who can use MDMA every week -- for years, with no loss of effect, and no adverse issues.
 
absurdly high doses of vitamin c should help against neurotoxicity in animals (it's very doubtful if neurotoxicity exists with recreational doses in humans). but the amounts need are really huge, likely to give you diharrea, and vitamin c isn't that lipid soluble, so who know if enough even makes its way over the blood brain barrier. i think your better bet would be a combination with some vitamin e.
but really, neurotoxicity shouldn't be an issue anyway if you stick to sensible doses. the mood disorders/... should rather be due to receptor/transporter downregulation and serotonin depletion. and antioxidants are not going to do a thing there. the only thing that works here is keeping your doses in a humane range and making langer breaks between drops.
 
Black said:
absurdly high doses of vitamin c should help against neurotoxicity in animals (it's very doubtful if neurotoxicity exists with recreational doses in humans). but the amounts need are really huge, likely to give you diharrea, and vitamin c isn't that lipid soluble, so who know if enough even makes its way over the blood brain barrier. i think your better bet would be a combination with some vitamin e.
but really, neurotoxicity shouldn't be an issue anyway if you stick to sensible doses. the mood disorders/... should rather be due to receptor/transporter downregulation and serotonin depletion. and antioxidants are not going to do a thing there. the only thing that works here is keeping your doses in a humane range and making langer breaks between drops.
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serotonin depletion is a myth -- else 2-CB. LSD, etc would not work after using MDMA

vitamin c easily crosses the BBB

6 grams per day of vitamin c is easily taken orally without causing diarrhea
 
epic11 said:
NO. JUST NO. Its not about "can i roll" Its more about "what invisible damage have i done?" Next thing you know you are depressed....... for a year or longer. Dont fuck with this drug. It will embarrass you.

Golden rule, wait 3+ months between rolls and DO NOT BREAK THIS. Seriously......... Dont say i didnt warn you. I never abused it and still went through a depression that was horrible. Ive come to realize that 1 month wait is not long enough. This shit is powerful.
Click to expand...


The whole neurotoxicity multiple days blah blah is a load of crap.

In PIHKAL for the MDMA entry, Shulgin describes a HUMAN SUBJECT MDMA tolerance test. They gave people 120 mg the first day, and dosed at 9 am another 5 days in a row ending at 160 mg dose -- to see how tolerance developed. Then on day 7, they gave the subjects 120 mg of MDA to test cross tolerance (there isn't any).

Yup 7 days of 120 mg plus per day of MDXX --oh my god those people must be so screwed up --- but wait,

The subjects took a drug holiday (no drugs) for 6 days -- and were given 120 mg of MDMA on day 7 -- and the effects were substantially as expected. only 6 days for tolerance to reverse itself after basically a gram of MDMA over a week (laboratory pure MDMA)
 
shugenja said:
The whole neurotoxicity multiple days blah blah is a load of crap.

In PIHKAL for the MDMA entry, Shulgin describes a HUMAN SUBJECT MDMA tolerance test. They gave people 120 mg the first day, and dosed at 9 am another 5 days in a row ending at 160 mg dose -- to see how tolerance developed. Then on day 7, they gave the subjects 120 mg of MDA to test cross tolerance (there isn't any).

Yup 7 days of 120 mg plus per day of MDXX --oh my god those people must be so screwed up --- but wait,

The subjects took a drug holiday (no drugs) for 6 days -- and were given 120 mg of MDMA on day 7 -- and the effects were substantially as expected. only 6 days for tolerance to reverse itself after basically a gram of MDMA over a week (laboratory pure MDMA)
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Registered May 2015........... Sorry brotha. Dont come in here spreading mis-information. This drug WILL fuck you up if you dont follow basic HR with it. Dont roll multiple days, and take proper breaks between rolls. This isnt a game. The thing about its affects, most people dont notice them until they wonder why they hate everyone and everything.
 
epic11 said:
Registered May 2015........... Sorry brotha. Dont come in here spreading mis-information. This drug WILL fuck you up if you dont follow basic HR with it. Dont roll multiple days, and take proper breaks between rolls. This isnt a game. The thing about its affects, most people dont notice them until they wonder why they hate everyone and everything.
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Refute the science -- not the messenger.

BTW -- did you know that MDMA increases cortisol secretion by 800%, that cortisol causes serotonin receptor dysfunction, that cortisol damages cells in the hippocampus

That vitamin C block cortisol release ??

Did ya
did ya??
 
epic11 said:
Registered May 2015........... Sorry brotha. Dont come in here spreading mis-information. This drug WILL fuck you up if you dont follow basic HR with it. Dont roll multiple days, and take proper breaks between rolls. This isnt a game. The thing about its affects, most people dont notice them until they wonder why they hate everyone and everything.
Click to expand...


You are the one spreading BS like serotonin depletion. There is no such animal -- unless you are on a tryptophan deficient diet.
 
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