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Lysergamides The Big & Dandy 1P-LSD Thread - Volume 2

Viv said:
Is the prodrug thing still in question? I saw Nichols noting that it definitely is one, and the human serum study backed that up. Only thing they haven't tested is actually in vivo, but it seems like there shouldn't be any ambiguity about it at this point. Also on a personal note I can't tell the difference between 1P and L at all, although that's just a personal anecdote, not real data.
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Hi. As far as I'm concerned, it was never in doubt (the pro drug theory). Nichols is though, a molecular pharmacologist and not a molecular biologist so to me it isn't surprising that it took a while for him to come around to that viewpoint. I don't think he's too convinced about 1P being able to cross the BB barrier though, which is still something I believe happens (or can happen in some individuals).

Here's the odd thing Viv; having never tried LSD I can't tell you how similar it is (or isn't). All I can say is it's a world of difference for me from LSZ, mushrooms, 4-AcO-DMT and 4-HO-DiPT; this being the only hallucinogens I've tried. I also tried AL-LAD sugar cubes, but I'm pretty sure I screwed up the preparation on those :(

Tom
 
weirdling said:
I used to have a similar issue on LSD trips - muscle tremors, sometimes even downright cramps, and I've learned to accept it. At the time, as my LSD use was just starting, I was drinking quite heavily and almost daily, and my diet was poor. I thought nothing of it back then.

A couple of years later, I don't really enjoy alcohol anymore, hence rarely use it. My diet is still not the best, but I use vitamin and mineral supplements daily. Quite a broad spectrum of them - pretty much the vitamin alphabet ;)

The reason I mention all this - I completely stopped experiencing tremors on LSD and other lysergamides. Whereas I sometimes used to find myself a shaking, jerking mess while tripping, nowadays, I don't get even the slightest twitch. I am inclined to believe that, back when I used to get tremors, I was suffering from a vitamin and/or mineral deficiency, as heavy alcohol consumption is known to deplete vitamin stores in the body - particularly the B vitamins, which are crucial in ensuring healthy functioning of the CNS.

I'm not saying this is in any way related to your case. Just throwing it out there, since your post reminded me of it. LSD tremors are an interesting topic - clearly, they are "a thing", and many people report them, but at the same time we don't really have a good understanding of why they happen.
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This is a very interesting point. Every time I've had the muscle tremors/cramps from LSD, it was during a time period where I was drinking heavily and had poor diet - not eating junk food, more like just not really eating much at all. That's awesome to hear that you can enjoy L now that you are healthier. I have recently quit drinking, hopefully after some detoxing and healthier living I'll be able to enjoy L without turning into a shaking mess. Thanks for the insight!
 
Bluuberry said:
This is a very interesting point. Every time I've had the muscle tremors/cramps from LSD, it was during a time period where I was drinking heavily and had poor diet - not eating junk food, more like just not really eating much at all. That's awesome to hear that you can enjoy L now that you are healthier. I have recently quit drinking, hopefully after some detoxing and healthier living I'll be able to enjoy L without turning into a shaking mess. Thanks for the insight!
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this resonates with me.. i have been dissociated, sedated and knocked out/unaware for so long.
psychedelia calling me back is a surprise. how ive cleaned up.. i bought some running shoes and

put a hit under my tongue till i walk home. flushed most everything,and damn alcohol is a poison.

i mean as a poly drug abuser and compulsive doser, having only hard tryptamines around
becomes quite the debate, when all you wanna do is catch a 'fix' but what you have to fiend to if
you will is only going to reinforce your own self
 
Dubnaut thanks for sharing.

As a "sober" "vegan". Who just fell in love with live music and meditation after 10 years of poly drug abuse, I hafta say I feel you sentiment.
 
Hi, guys
I've had three trips on 1p-lsd so far (100 mics, 200 mics, 300 mics). They were all mixed experiences, but all have positive feedback. Now I'm planning a 800 mics trip. I was wondering if that was a physically safe dose, considering the substance is not researched. I'd also love to hear some advise from more experienced users.
 
It's safe, but 300 to 800 is a pretty big jump

I'd say wait a couple of months and try 500 if you are really looking to get far out
 
Bufislav said:
Hi, guys
I've had three trips on 1p-lsd so far (100 mics, 200 mics, 300 mics). They were all mixed experiences, but all have positive feedback. Now I'm planning a 800 mics trip. I was wondering if that was a physically safe dose, considering the substance is not researched. I'd also love to hear some advise from more experienced users.
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As far as we know, this compound should have a safety profile most closely resembling ALD-52, which in turn has a safety profile similar to LSD-25.

With that said, I would strongly suggest staying around 400-500mcg unless you have experience with other lysergamides. Although the dose-response curve is logarithmic with these compounds, there is still going to be a very large difference between the effects of 300mcg and 800mcg.

Basically, although it may seem enticing to jump in the deep end with LSD, you may be biting off more than you can chew at 800mcg.

Have fun, be safe.
 
Yeah, I'd be careful too. Get some poppers & nitrous and play with that a bit during a trip. It's really intense, but shortlived, so (I think) it gives you an idea what the deep end can be like without being stuck in it for hours on end.
 
I've been looking for the info about storage and cannot find it. Anyone could drop me the link to it?

What I actually want to know is how long could I expect to storage 1p-lsd in freezer without degradation. Will it be best to storage in blotters or solution? And if solution what is the best solution?
 
Blotters, airtight, away from heat, moisture & (uv) light, freezer is not recommended unless you intend to store it for a really long time (several years) because taking it out might cause condensation. Without a freezer in decent conditions it should keep for well over a year anyway, it's really stable on blotter.
 
No, but you'll need optimal circumstances. I'm thinking vacuum sealed, with dissicants, in another light-tight container, in the freezer. Of course almost no one actually did something like this, but I hear that's 'the best' long term storage method.
 
The Hypnotist said:
I'm thinking about decades...Am I crazy?
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You're not crazy. I have read anecdotal reports of LSD-25 lasting upwards of 5 years.

I think storing for multiple decades is just a tad bit too optimistic, both logistically and realistically.
 
I still have some al-lad and lsz left from the original batch and the last time i tried them they didnt seem to have lost any potency at all and that must be around three years ago and i only store them in original baggie inside a book i a dark drawer
 
I am keeping one blotter of 1P-LSD in a drawer, wrapped in foil. I want to see if it loses any potency after a year stored like that. It's been almost a year actually, so I will take it very soon to test the potency and report.
 
I am wondering if you had some say twenty years and they had degraded by 50 % would doubling up the dose get you the same effects or would the degradation cause any impurities and affect the trip. I am just wondering if they would degrade that much or even more over that time scale
 
I reckon if you stored them properly, away from heat light moisture air etc they wouldn't degrade by that much at all.

Coupled with the active dose being in the microgram range I don't think any impurity would be active at that level.
 
zombywoof, I would guess it is the same as with the clean/dirty acid debate: Even if there are impurities they would hardly be active at that dosage. So yeah I would think taking two blotters of 50% degraded stuff should be the same as taking one blotter of non-degraded stuff. Not that I'm an expert...

Edit: Wait... was that your question or were you asking if 50% degradation over 20 years is a realistic figure? No idea on that one...
 
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