Just A Guy
Bluelight Crew
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- Feb 2, 2013
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This is the second installment of the 1P-LSD B&D. To visit Volume 1, click here.
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Welcome to the Big & Dandy 1P-LSD Thread, Volume 2
1-propionyl-lysergic acid diethylamide
Introduction
Legality & Stability
Trip reports:
original post:
New lysergamide about to go on sale. I haven't tried it yet.
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Welcome to the Big & Dandy 1P-LSD Thread, Volume 2
1-propionyl-lysergic acid diethylamide
Introduction
1P-LSD, NP-LAD or 1-Propionyl-lysergic acid diethylamide is a research chemical and novel LSD analogue. It is very structurally related to LSD, differing only in the propionyl group on the 1-position. The mythical analogue ALD-52 is again very similar, having a 1-acetyl instead of 1-propionyl. It has been remarked by - at least - David Nichols that based on lysergamide SAR, 1P-LSD itself should not be active but metabolizes rapidly in the body to form LSD. That would mean that the only difference with LSD would be pharmacokinetic effects, which after all may affect the subjectively experienced trip. However these claims certainly could be more substantiated.
Legality & Stability
It is illegal in the United States under the federal analogue act as well as in Australia under similar legislature.
Purportedly compounds like 1P-LSD and ALD-52 are not as unstable as once thought. This may be important since it would otherwise tend to spontaneously degrade into LSD which is of course a legal hazard.
It could be argued that it is very unlikely to hydrolyze to LSD under standard conditions. Basic or strongly acidic conditions may make hydrolysis more favorable, so store your 1P-LSD accordingly, I recommend not using ascorbic acid as an anti-oxidant for instance since it is acidic.
Supposedly acetyls are known stable protecting groups for indoles. It is plausible that this literally and figuratively also extends to propionyls.
http://www.organic-chemistry.org/protectivegroups/amino.shtm
On the other hand, Nichols says that:
But it is unclear whether that includes spontaneous hydrolysis under standard conditions.It is well known in organic chemistry that N-acyl indoles of all kinds hydrolyze easily.
Again, this needs further substantiating. Hopefully analysis will soon clear this up.
For the time being, it is advised to assume that similar storage conditions apply as for LSD. And Bluelight is not claiming that this is necessarily stable and safe legally for you to buy, own or use. We do not accept responsibility regarding legal matters, and decisions made by users browsing this forum.
Trip reports:
- Anarch - 100 ug report
- Si Ingwe - First tries (apparently) with 75 ug and 100 ug
- Zombywoof's acquaintance - 100 ug report
- Wubb's notes - 100 ug
- Lib Mentis - Pleasant introduction on 100 ug
original post:
New lysergamide about to go on sale. I haven't tried it yet.