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Urgent: speed the day after xtc especially damaging?

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MrRabbit

Greenlighter
Joined
Aug 13, 2012
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8
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Belgium
Does anyone know how long to wait before using speed after mdma? Is 24 hours, including a good night's rest and a rave aid/vit C regimen, enough?

I read in a white paper that brain toxicity happens when dopamine enters in the serotonine storage cells after a massive serotonine release.

I fear that when speed is consumed the next day, toxicity might get worse because there's still not much serotonin so dopamine might again go where serotonin should be, thus creating way more damage than if xtc and speed were used further apart in time.

Can anyone confirm/deny that this would happen?
Does enough serotonine get regenerated in 24 hours to prevent this from happening on a next day speed trip.

Thanks for any info!
 
MrRabbit said:
I read in a white paper that brain toxicity happens when dopamine enters in the serotonine storage cells after a massive serotonine release.
Click to expand...

this has been disproven for a long time now. don't worry.
 
MrRabbit said:
Can anyone confirm/deny that this would happen?
Does enough serotonine get regenerated in 24 hours to prevent this from happening on a next day speed trip.

Thanks for any info!
Click to expand...

I'm not familiar with speed, but the serotonin takes around 30 days (or more) to regenerate. That's why you should respect the 30 days to roll again. Based on that, I'd say that there's no way that you generate something in 24 hours.
 
nightElf said:
I'm not familiar with speed, but the serotonin takes around 30 days (or more) to regenerate. That's why you should respect the 30 days to roll again. Based on that, I'd say that there's no way that you generate something in 24 hours.
Click to expand...

yup, but amphetamine barely affects serotonin, so there shouldn't be any problems.
 
MrRabbit said:
Thank you. Do you have a reference?
Click to expand...

sorry, i don't. we've discussed the literature years ago in NPD and i can't find the relevant papers now. but it was only one hypothesis of many and it surely doesn't turn up in recent literature.
 
The last time I did MDMA the next day I took 2mg of Xanax and 60mg dexamphetamine and smoked lots of pot. I've always wondered about the potential neurotoxicity of what I did. Based on the answers here it seems nothing significant outside of short term psychological/physical harm.

The days following were rough, no doubt.
 
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