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I Like to Draw Pictures of Random Molecules

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b-hydroxythiolofentanil:

j3Jl3Nd.png


7-nitro 5-pyridin-2-yl analog of temazepam (tenazepam?)

xzWaRq3.png
 
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Your fentanyl analogue would do better without the beta-hydroxy functional group.

As for the added carbomethoxy (R-CO2CH3) group, I'm pretty sure that it is a shorter lasting bioisostere of the N-(C=O)CH2CH3 group where the middle methylene unit (-CH2-) has been replaced by an oxygen atom to form the ester. Which gives me an idea!

beta-(C=O)CH2CH3-methylphenidate. Should be a real long laster.
 
Hey everyone, still need images at my: https://en.wikipedia.org/wiki/List_of_cocaine_analogues (List of cocaine analogues) ...any help would be appreciated. I've changed it quite a bit since even I last asked (it's now bigger than the list of phenyltropanes page, btw.)

Also I've started a: https://en.wikipedia.org/wiki/List_of_methylphenidate_analogues (List of methylphenidate analogues)

So anyone interested in any attestable examples of novel methylphenidate derivatives can draw them out, release them at Wikimedia Commons and I'll include them along with the citation of it's creation/use.

That's it, I'll stop using this as my personal image request mill. ;-p Thanks all.
 
perpetualdawn said:
Has this been synthed? Sorta hybrid between methylphenidate and MDMA
w9sktu6.png
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Problem is, they have completely different modes of action. MDMA being a releaser by phosphorylation of SERT, and the MPH & cocaine type DARIs apparently having a unique ligand binding site which causes DAT 'inverse agonism'

However, increasing the anesthetic aspect of cocaine by adding that of menthol might be interesting, esp. since cocaine often gains potency with a substitution at the 2-beta position:
Cocamentholene.jpg


It's often found that cocaine and menthol are used together with the latter being an adulterant due to the numb/freeze sensation. I wonder if they bonded on the molecular level what the outcome would be. I call it "cocamentholene", the newest drug craze sweeping the inner cities. ;-P
 
Like the 3,4-methylenedioxy version of 4-methylaminorex, the 3,4-MDO analogue of methylphenidate has never been tested or appeared on the research chemical scene to my knowledge. And it's not for a lack of me and other people suggesting that they be made and tested. In fact, someone posted an (unauthorized) picture taken of the blackboard of Alexander Shulgin before he died with the structure of 3,4-MDO-4-MAR drawn out with the caption, "Make Me," under it.

As for the cocamentholene, I would expect it to have greatly reduced activity compared to cocaine based on the analogy--which may or may not be an accurate one, admittedly (the only way to know any of this for sure is to make the compound and test it for activity)--that EPH is of greatly reduced activity to MPH, and MPH and cocaine share similar modes of action along with a carbomethoxy group as well.
 
It could be then that cocamentholene is more active than cocaine. However, after the troparil and 4-F-cocaine big disappointments, I really only trust human reports of bioassays of tropane derivatives.
 
Dresden said:
It could be then that cocamentholene is more active than cocaine. However, after the troparil and 4-F-cocaine big disappointments, I really only trust human reports of bioassays of tropane derivatives.
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As one should with anything. Molecular neurochemistry is in the same dark as quantum physics, for the most part.

I filled out my List of 'methylphenidate analogues' wikipedia page with images:
MPH380analog.jpg
MPH381analog.jpg
MPH382analog.jpg
MPH383analog.jpg
MPH374analog.jpg


I wonder how many other, bridged, rings et al., have been substituted at the piperidine ring of methylphenidate... An endo-etheo bridge perhaps? A tropane?

Here would be an odd one: "cis-propenyl 2-{2-azabicyclo[2.2.2]oct-5-en-3-yl}-2-phenylacetate"
 
at least one of those should be as good as etizolam:

ky82cb1yexxw.png


any more places to put nitrogen?
1fmpesfdndz5.png


maybe theese could be nice muscle relaxants:

lahjnpu1av8.png

2si61u54wsp.png
 
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Lol... oh my sekio, busting a gut. I think you remember me doing this one before, don't be so sly. I rendered it a little differently this time. Your response before was more aghast when I said what it was. lol
 
I think I remember this one now. It's a bastardized mitragynine-morphine hybrid.

I don't think the hemiacetal would like to stick around in water, though.
 
sekio said:
I think I remember this one now. It's a bastardized mitragynine-morphine hybrid.

I don't think the hemiacetal would like to stick around in water, though.
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No, no no, there was a super-big hint I gave in the above post. Not mitragynine, it's not a hybrid with another opioid... but *something* else. (duh. ;-P )

here it is mixed with heroin (as is often done, on a non-molecular but simple co-occurring solution made level, among drug users)

xEyfJ.jpg


The other constituent may be considered a 'restricted rotation' analog though to share as many parts with the morphine skeleton as possible. But there are variants of this compound which have second nitrogens close to where the morphine skeletons nitrgoen is, etc, and the other parts don't necessarily make it not do its function either, except for that it is restricted in its movement (the carbon ring would normally be freely rotating in the other substance it is a hybrid with)
 
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