Is this combo safe?

[Xcdx100]

200mg pregabalin (lyrica) + 1mg clonazepam + 1mg lorazepam + 25mg benadryl
Im planning on taking the above later tonight so im ok if it puts me to sleep but otherwise is it safe or are the dangers of CNS depression to high?

 

[pasha]

there should be no issues. especially if you have a tolerance to any of said drugs. pregabalin and benzodiazepines though are a pretty knock out combination so watch out. maybe take 1 benzo instead of two.

homeless -> basic drug discussion

 

[Xcdx100]

I have a tolerance to benzos but not pregabalin.
I feel some anger for some reason after 200mg lyrica and .5mg clonazepam

 

[Xcdx100]

there should be no issues. especially if you have a tolerance to any of said drugs. pregabalin and benzodiazepines though are a pretty knock out combination so watch out. maybe take 1 benzo instead of two.

homeless -> basic drug discussion

Do you know why by any chance?

 

[pasha]

it's because pregabalin doesn't seem to have any negative implications on respiration. neither do benzodiazepines to such a great extent in regular dosages and what happens more than anything during the combination of both is marked potentiation of benzodiazepines gabaergic effects. your pregabalin dose is also not excessive for what people tend to take recreationally.

if you feel angry, that might be lyrica or benzo rage.

 

[Xcdx100]

it's because pregabalin doesn't seem to have any negative implications on respiration. neither do benzodiazepines to such a great extent in regular dosages and what happens more than anything during the combination of both is marked potentiation of benzodiazepines gabaergic effects. your pregabalin dose is also not excessive for what people tend to take recreationally.

if you feel angry, that might be lyrica or benzo rage.

Thanks for the help, but if u have time i have one last question.. In ur opionion should i leave the benadryl out and use promethazine or neither?

 

[pasha]

not a problem.

both anti-histamines, it all depends on which one you prefer but i would use neither. like i said, benzo's with lyrica alone is pretty knockout stuff. really, it might not hit you straight away but when it does you'll certainly feel rocked.

try promethazine with lyrica without the benzo sometime and see how that feels compared. also nice in its own regard. my personal favorite in years and years of lyrica use is hydroxyzine with lyrica without a benzo. the anti-histamines with negligible anti-cholinergic activity tend to synergize with lyrica the best and disrupt its effects least.