a week or 2 between rolli

[PGC-124]

hey everyone,

I have little experience with Drugs, mainly cannabis and some opiates.

I dropped my first mdma roll 10:30 am this Monday and had the best experience. few side effects,
and no hangover after some cannabis.

The pill was round, green with a playboy logo. think it was mdma and caffeine

A rare occasion starting next weekend. and would like to drop ones more. I have read countless forums about frequently usage and about the Serotonin possess. And of course the thousands of opinions out there. Yet I cant find the answer Im looking for......

I usually am an consumer in stages where I have one month a year where I can take everything and be clean the rest of the 11.

I would like to know what possible damage can do to my brain, with a 2 weeks pause between these 2 rolls?
I take some multivitamins everyday and aminoacids. ordered an bottle of 5-htp but I wont receive my package before mid December (6 weeks from now)

(we are talking about these 2 rolls and a LONG brake afterwords)
I know this can hit me on the tolorance point, but can this "kill the magic" ?

hope this text is not to messy build xD

cheers :-D

 

[myr]

Hi! While it is not the brightest idea from harm reduction's point of view, a one-off occasion won't damage your brain or anything like that. You may experience more side effects than last time. Since it's your second time it will be as or nearly as good as your first.
Nex time don't forget to test your stuff, you can buy testing reagent online, not expensive and worth it as it can potentially save your life and also you can be more confident about having a great night knowing it's mdma and not - say - methylone which is not nearly as magical.
Then keep your word and stay off of it for a while and do breaks of 1-3 months inbetween rolls.

 

[JWills20]

You will be fine. Just don't make a habit of it. The real dangers of MDMA arise from weekly use over a sustained period of time.

 

[PGC-124]

Thanks for your replies, I will look into those kits and try to keep mdma as holy as Christmas. may I ask what you guys do when you get grinding teeth the days after ?
I think I have bought over 10 packs of gum the last 4 days xD

 

[mb-909]

The danger's of frequent use of MDMA is not only that your receptor's downregulate, it is also that it takes way longer to metabolise. After one dose of MDMA the metabolism by CYP2D's is significantly decreased, which means that every drug working on the same metabolism is going to stay longer in higher concentrations in your body (my theory!). This can last for up to one week after a single dose. If you redose often or take it daily this impairment of the metabolism will be increased for a longer period of time (longer than a week) depending on your frequency. So be carefull if you do it often, because it can increase the risk and doses of other drugs as well!

 

[Black]

The danger's of frequent use of MDMA is not only that your receptor's downregulate, it is also that it takes way longer to metabolise. After one dose of MDMA the metabolism by CYP2D's is significantly decreased, which means that every drug working on the same metabolism is going to stay longer in higher concentrations in your body (my theory!). This can last for up to one week after a single dose. If you redose often or take it daily this impairment of the metabolism will be increased for a longer period of time (longer than a week) depending on your frequency. So be carefull if you do it often, because it can increase the risk and doses of other drugs as well!

up to one week? do you have any sources? i though mdma would inhibit the enzymes reversibly (so that once the mdma is gone they're back to where they were before)...

 

[myr]

up to one week? do you have any sources? i though mdma would inhibit the enzymes reversibly (so that once the mdma is gone they're back to where they were before)...

"MBI occurs shortly after a single recreational dose, inactivating most hepatic CYP2D6 within 2 h, and returning to a basal level of CYP2D6 activity after at least 10 days (O'Mathúna et al., 2008; Yubero-Lahoz et al., 2011)"

http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18794647

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=21456632

 

[Black]

"MBI occurs shortly after a single recreational dose, inactivating most hepatic CYP2D6 within 2 h, and returning to a basal level of CYP2D6 activity after at least 10 days (O'Mathúna et al., 2008; Yubero-Lahoz et al., 2011)"

http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18794647

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=21456632

very interesting. thanks.
that's indeed important info for people on medication (or those planning to take other drugs in the following week).

 

[myr]

Well, I have no idea how this translates to IRL scenarios. A study also suggests that once CYP2D6 is inhibited, other CYP enzymes take over the metabolism of MDMA (well, it breaks down somehow eventually). But it can be important for someone taking medication that can only metabolized by 2D6 - if there's such a med.

 

[mb-909]

I was accidently on Abilify (around a low of 0.6 mg, takes longer than I thought to clear the body) working exactly on these enzymes, which could be the reason why I couldn't sleep for day's. Usually the liver is flexible producing other enzymes to counter react and if nothing else helps it will be cleared by the urine to some extent... At least my anxienity helped me to understand pharmadynamics. Yeah! .

By the way is it normal to have tremors after taking MDMA? I only had it once, and I am still not sure if that one pill contained PMA or amphetamines... I will never know.

Edit: It seems to be pretty normal to have a tremor afterwards...

Edit2: Just noticed that I only did 20 mg of MDMA my first time. Yeahhh