So is there any chance of risk I was put on. I acted stupidly, I know, couldn't control myself
. I didn't feel anything during the trip, besides being more acticve and a little positive.
"Aripiprazole's
mechanism of action is different from those of the other FDA-approved
atypical antipsychotics (e.g.,
clozapine,
olanzapine,
quetiapine,
ziprasidone, and
risperidone). Rather than
antagonizing the
D2 receptor, aripiprazole acts as a D
2 partial agonist.
[51][52] Aripiprazole is also a partial agonist at the
5-HT1A receptor, and like the other atypical antipsychotics displays an antagonist profile at the
5-HT2A receptor.
[53][54] It also antagonizes the
5-HT7 receptor and acts as a partial agonist at the
5-HT2C receptor, both with high affinity. The latter action may underlie the minimal weight gain seen in the course of therapy.
[55] Aripiprazole has moderate affinity for histamine, α-adrenergic, and D4 receptors as well as the
serotonin transporter, while it has no appreciable affinity for cholinergic muscarinic receptors.
[44]
D
2 and
D3 receptor occupancy levels are high, with average levels ranging between ~71% at 2 mg/day to ~96% at 40 mg/day.
[56][57] Most atypical antipsychotics bind preferentially to
extrastriatal receptors, but aripiprazole appears to be less preferential in this regard, as binding rates are high throughout the brain."
As I see it blocks some of the 5-HT receptors. It also seems to block the 5-HT1 receptor (saying partial agonist) and so it should mean that it couldn't cause a serotonin syndrome, or? On the other side it also is a substrate of
CYP2D6 and
CYP3A4 . Those are also important for MDMA metabolismn. So does anyone know if there could be severe side effects, since most of mdma neurotoxicity has been linked to the mdma metabolismn?
Edit: Myr was faster...
The sleeping problems should be a result of too less Serotonin.
Edit2: It seems to be neuroprotective, at least i hope it is.
... Wont ever be doing two days in a row from now on haha