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Opioids oxy IR question

Stotched said:
Why would you even ask if plugging would have a better effect, when you're still going to do it after everyone else told you to eat em? Eating them has a 87-90% bioavailability. That's insanely high for a pill. don't be so antsy for that instant gratification, and just eat them. And when you eat them with a fatty meal, or even some omega 3 caps with milk, it seems to even double the effects. Oxy has been proven to be the best when eaten (almost as good as mainlined), but yeah, you wont get that rush. Just saying, you're taking twice as much as you need to be if you arent eating them. I used to be like you, until I got an ungodly tolerance, and started eating them to save money.
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Keep in mind not everyone absorbs oxycodone quite the same. Although to me and you eating them has better effects than snorting, for some people the B/A isn't so high when taken orally its more around the 50-60 percent range versus 80℅ for people like us. For the people who don't absorb it well the rush from snorting makes more sense for them because they get about the same bioavailability as they would have if they eaten it but with faster onset. Insuffalation could even be greater than oral for some people which seems to be the OP's case.
 
k the assmaster has tried it. first I plugged 20mg IR and nothing much. waited an hour and plugged another 30mg IR and now I have the same buzz and pain releaf as eating em. so to me its the same. eat em, not as messy.............
 
oh and I had somewhat of a high fat lunch.........I was reading on us gov website that rectal administration had rates of 60% with error ratio of 30% hahah so depends on the person I guess, ass or mouth is the same for me. I will eat em from now on. or snort em.
 
plug it and it is 2x a strong ! it is for me anyway i feel why higher when i snort or plug oxy 30mg ir ! hands down. i could care less what the medical BA is all i know is what works
 
Both oxycodone bioavailability and peak plasma concentration are greatly altered by eating a high fat meal.
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The BA isn't going to significantly change because its already high. Serum levels will be higher, though.
 
hoopy said:
oh and I had somewhat of a high fat lunch.........I was reading on us gov website that rectal administration had rates of 60% with error ratio of 30% hahah so depends on the person I guess, ass or mouth is the same for me. I will eat em from now on. or snort em.
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hoopy, You never really know unless you try. So now you know & like some of the others have said, everyone is different & responds differently to drugs & the ROA.


Jen
 
you are so right, so I did try.............I plugged 50mg IR (in total), ate 20 more and snorted 30mg more of IR and if it was not for my clomazapam I woud be just fine, dam my tolerance has gone way up on oxy after being on hydromorphone for so long. what a waste of good drugs hahahah and my fucken pain is still the shits.......
 
Sorry to hear about your pain :(

Dam that's a lot of oxy to not feel any relief tolerance is a bitch isn't it? See like I said some people react differently to ROAs you can see the odd person coming on here swearing by rectal administration saying it gets them the highest whereas others don't see nothing special because its basically the same as eating the pill. Plus no need for violating your bum haha

Mabye its time for a tolerance break?
 
bobjayne said:
The BA isn't going to significantly change because its already high. Serum levels will be higher, though.
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and why will the plasma concentrations get higher but not the bioavailability??

I think you just enjoy arguing I would have a debate with you again but I see your an ex Bluelighter so guess we can't.
 
hoopy said:
I have some oxy 10mg Instant release, have been snorting them when needed for pain. Question is can you plug em? will oxy instant release dissolve in water easy once crushed? anyone?
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Not really. Why don´t you parachute them?
 
ya a tolerance break isn't a bad idea, I live in 24 pain, so its tough to take a break.
 
the only way for me to take a tolerance break (as pathertic as this sounds) is two take just enough ER in the morning not to withdraw too badly, and drink for a couple days.............. I just might have a to get the johnny walker out soon. hahaha
 
hoopy said:
the only way for me to take a tolerance break (as pathertic as this sounds) is two take just enough ER in the morning not to withdraw too badly, and drink for a couple days.............. I just might have a to get the johnny walker out soon. hahaha
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Drinking would only make it worse.
 
Tolerance is a real bitch, that is for sure! I was taking just oxycodone, 10mg 1-2 every 4 hrs for chronic pain. My doctor thought I should give the fentanyl patches a try. I agree, it was nice not having to worry about taking pills every 4 hrs. Instead you just change a patch every 48 hrs & be done with it, might need to take a pill every now & then for breakthrough pain. They worked great for pain relief but my body did not agree to liking them. So after 2 months of being on them I have had to wean myself down & am now coming off them completely on Monday. I'm soooo ready to be done with these stupid ass patches! Anyways the fentanyl has now doubled my opiate tolerance, after only 2 months. So now I will have to take 20mg of oxycodone 1 to 2 ever 4 hrs for pain control. At first I was pissed at the doctor because of this. Now that I have had a month to reflect on it all I'm no longer pissed, just annoyed that I even agreed to try the patches. They are so strong and I now understand why in some states they are only given to terminal patients who will obviously not need to come off of them. They are a bitch to come off of. I'm just glad I was only on them for a short time, unlike some of the horror stories I have read where they have been on them years & then have to come off that crap.
 
What was your Fentanyl dosage? Fentanyl is one of the strongest opiates I´ve ever come to know. Some say it´s more than 50 times stronger than Morphine. Reason of which they measure the dose in micro mg. The starting dosage is 25 mcg and it goes on until 125 mcg. It´s very difficult to quit. And if you need to do so, the equivalent dosage of Methadone will be very large.
I had to use Fentanyl due to a extremely painful surgery but the doctor limited the timing frame not to exceed 3 weeks. During this period I took nothing else but Fentanyl. Not even Methadone which was 70 mg per day.
You are right about the horror stories about Fentanyl abuse. It´s very hard to come off. And you need doctor´s assistance plus a lot of other drugs.
 
Erikmen I made it up to the 75 mcq fentanyl patch when I decided the med wasn't for me. It is also the strongest opiate I have ever known. I read it was 80 times stronger than morphine, so it's def up there! I refuse to take methadone and in this state it's not something you can get from your general practitioner. I would have to go to a methadone clinic and then your labeled an addict for life & will never be able to get any controlled substance from any doctor ever again. My doctor and I have done the conversions & the oxycodone 20 mg, 1 to 2 every 4 hours will be equivalent to the 75 mcg of fentanyl that I was on. Although I did wean down to 25 mcg over the last month. I was put on fentanyl because of chronic pain. I was hit head on by an F 150 truck while I was riding my motorcycle, so I will be needing to see many doctors for the rest of my life, unfortunately. That is another reason methadone is not an option.

Jern
 
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they want to put in a pain pump in my spine, that would be refilled monthly. I am thinking about it.
 
jennie76 said:
Erikmen I made it up to the 75 mcq fentanyl patch when I decided the med wasn't for me. It is also the strongest opiate I have ever known. I read it was 80 times stronger than morphine, so it's def up there! I refuse to take methadone and in this state it's not something you can get from your general practitioner. I would have to go to a methadone clinic and then your labeled an addict for life & will never be able to get any controlled substance from any doctor ever again. My doctor and I have done the conversions & the oxycodone 20 mg, 1 to 2 every 4 hours will be equivalent to the 75 mcg of fentanyl that I was on. Although I did wean down to 25 mcg over the last month. I was put on fentanyl because of chronic pain. I was hit head on by an F 150 truck while I was riding my motorcycle, so I will be needing to see many doctors for the rest of my life, unfortunately. That is another reason methadone is not an option.

Jern
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I´m sorry to hear that. Good luck!
 
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