-
OD Moderators: Keif’ Richards | negrogesic
Opioids oxy IR question
- Thread starter hoopy
- Start date
Smoky
Bluelight Crew
good question!
I don't think you'll get a higher bioavailability than just taking them orally, but it's possible. there is an extraction method…
I don't think you'll get a higher bioavailability than just taking them orally, but it's possible. there is an extraction method…
They are very water soluble yes you can plug them but why would you want to? The B/A is so high when taken orally so why shove em up your butt? It yields pretty much the same result as taking them orally.Snorting those is also a waste try eating them chew a few uo and see what results you get. When I went from snorting to eating it felt like it almost doubled in strength with be same dose I used to snort. The bioavailability of snorting is actually lower than when taken orally.
I get way more buz from snorting than taking orally. I now would have to take 40 to 50mg orally to get pain releaf or a buzz. I snort 20mg and it works. that's just me.........that's why I asked.......I don't know the b/a is for oxy offhand for delivery methods.
purplehaze147
Bluelighter
- Joined
- Aug 19, 2010
- Messages
- 470
Plugging oxy is better than snorting or eating it. Trust me.
Smoky
Bluelight Crew
The immediacy of a rapid roa for me was always so gratifying, due to pain and withdrawal; although when i took the drug orally the gradual feeling was more pleasant sometimes. i also, didn't need to redose as often…
jennie76
Bluelighter
I think a lot of it is mental when it come to snorting them. I know the onset is quicker & a bit more intense but it is proven that the bioavailability is higher when taken orally. Trust me, I get why you prefer to snort them. This is something I struggle with personally myself. Its almost the ritual of snorting them itself that I enjoy more than anything I think.
Last edited:
Yes sometimes it does have alot to do with mentality why people enjoy snorting them I actually used to be the same way until I discovered oral hit me better and I felt the medication fully.
But some people do actually get about the same B/A from snorting as they would have if they ate the pill or even more because some people don't absorb oxycodone as well through the stomach. The bioavailability varies person to person depending on how efficient their body absorbs it and its metabolites. For instance Special populations, including children and those with liver/renal failure, have a unique profile that must be taken into account in order to maximize efficacy and reduce any adverse effects. Oxycodone is metabolized by the cytochrome P450 enzyme system in the liver, making it vulnerable to drug interactions this means many other drugs can also affect absorption of oxycodone. Some people are fast metabolizers, which can result in reduced analgesic effect, and increased adverse effects. Others are slow metabolisers, meaning without care its possible to result in increased toxicity without any improved analgesia at certain doses.
Typically The bioavailability of oral oxycodone averages 60–87%, with rectal administration yielding the same results. Intranasal varies between individuals with a mean of 46%. I'm one of the lucky ones who get a average of 80℅ bioavailability when taking oxycodone orally but some are more in the 60 ℅ range so to them it makes more sense to snort the stuff to get a faster onset if you don't mind messing up your nasal cavities.
Basically everybody is different and not everyone absorbs it the same way so the OP may very well be one of the people who doesn't absorb oxycodone effectively in the stomach.
But some people do actually get about the same B/A from snorting as they would have if they ate the pill or even more because some people don't absorb oxycodone as well through the stomach. The bioavailability varies person to person depending on how efficient their body absorbs it and its metabolites. For instance Special populations, including children and those with liver/renal failure, have a unique profile that must be taken into account in order to maximize efficacy and reduce any adverse effects. Oxycodone is metabolized by the cytochrome P450 enzyme system in the liver, making it vulnerable to drug interactions this means many other drugs can also affect absorption of oxycodone. Some people are fast metabolizers, which can result in reduced analgesic effect, and increased adverse effects. Others are slow metabolisers, meaning without care its possible to result in increased toxicity without any improved analgesia at certain doses.
Typically The bioavailability of oral oxycodone averages 60–87%, with rectal administration yielding the same results. Intranasal varies between individuals with a mean of 46%. I'm one of the lucky ones who get a average of 80℅ bioavailability when taking oxycodone orally but some are more in the 60 ℅ range so to them it makes more sense to snort the stuff to get a faster onset if you don't mind messing up your nasal cavities.
Basically everybody is different and not everyone absorbs it the same way so the OP may very well be one of the people who doesn't absorb oxycodone effectively in the stomach.
Last edited:
Stotched
Bluelighter
Why would you even ask if plugging would have a better effect, when you're still going to do it after everyone else told you to eat em? Eating them has a 87-90% bioavailability. That's insanely high for a pill. don't be so antsy for that instant gratification, and just eat them. And when you eat them with a fatty meal, or even some omega 3 caps with milk, it seems to even double the effects. Oxy has been proven to be the best when eaten (almost as good as mainlined), but yeah, you wont get that rush. Just saying, you're taking twice as much as you need to be if you arent eating them. I used to be like you, until I got an ungodly tolerance, and started eating them to save money.
jennie76
Bluelighter
I have read that if oxycodone is taken with fatty meal it increases the effects. Which I really do find strange because I've always thought I got better relief came with an empty stomach. However that was hydrocodone, so I guess that makes quit the difference also.
I know that people who have had gastric bypass or that type of surgery tend to have problems taken oral meds, which also makes since.
I know that people who have had gastric bypass or that type of surgery tend to have problems taken oral meds, which also makes since.
first off you have no idea who I am and what my tolerance is, If you read above eating them is not cutting it for me personally. I was just asking a question. I do have a huge tolerance and that is why I am looking for a another delivery method that might help save pills, that's all nothing more. and if you read up a couple people said to plug em. I do realise that eating them you SHOULD get the most out of them, yet I have found sometimes different delivery methods with different drugs will sometimes surprise and go against the science for one reason or another.
Last edited:
Aurelia
Bluelighter
I agree with Jennie. The ritual and the paraphernalia are large part of a habit.
Aurelia
Bluelighter
Well hoopy, tell us how it worked. I'm trying heroin for the first time to see if it kills pain. I'll post on Friday afterward.
So let us know.
So let us know.
jennie76
Bluelighter
bobjayne I'm pretty sure what I read said oxycodone, but I could easily be mistaken. A lot of people just call different drugs oxy, so it's very possible what I read was not about oxycodone at all... Please let me know if you find that is true with oxymorphone & not oxycodone. I have never been prescribed oxymorphone, however my husband takes that. So it would be good to know either way I guess, since we are both on theses meds.
Jen
Jen
jennie76
Bluelighter
If you are taking immediate release oxycodone, you can eat a high fat meal at the same time that you take oxycodone. Both oxycodone bioavailability and peak plasma concentration are greatly altered by eating a high fat meal. In other words, your body absorbs more oxycodone and will feel the effects of oxycodone longer when you take quick release oxycodone with high fat foods.
Extended release formulations have always been thought to have the best effect when taken on an empty stomach because of food interactions between the coating on the pill and the fact that the pill is supposed to dissolve in the upper digestive tract so it was thought food could interact with that process.
But studies have shown high fat meals have NO effect on ER formulations and can be taken with or without food obviously the advantage of taking an ER formulation on an empty stomach is having peak plasma levels reached much quicker than with a full stomach.
The effects of a high-fat meal on the bioavailability of oxycodone when administered extended release tablet or a 20 mg immediate-release (IR) solution, were evaluated in a randomized crossover study in 22 normal male and female subjects. Serial blood samples were collected for 36 h after dosing and analyzed for oxycodone. The results show There was no significant food effect with ER oxycodone.
For the IR solution, it still proved both oxycodone bioavailability and peak plasma concentration were greatly altered by consumption of the high-fat meal as I wrote above.
Extended release formulations have always been thought to have the best effect when taken on an empty stomach because of food interactions between the coating on the pill and the fact that the pill is supposed to dissolve in the upper digestive tract so it was thought food could interact with that process.
But studies have shown high fat meals have NO effect on ER formulations and can be taken with or without food obviously the advantage of taking an ER formulation on an empty stomach is having peak plasma levels reached much quicker than with a full stomach.
The effects of a high-fat meal on the bioavailability of oxycodone when administered extended release tablet or a 20 mg immediate-release (IR) solution, were evaluated in a randomized crossover study in 22 normal male and female subjects. Serial blood samples were collected for 36 h after dosing and analyzed for oxycodone. The results show There was no significant food effect with ER oxycodone.
For the IR solution, it still proved both oxycodone bioavailability and peak plasma concentration were greatly altered by consumption of the high-fat meal as I wrote above.
jennie76
Bluelighter
trainspotter10102 Thank you for clearing this up for me. I had not even considered the factors of the ER meds, which is one of the formulas my husbands takes. I only take the immediate release oxycodone so I have done very little research on the ER formulas.
Jen
Jen