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Opioids Loperamide (Imodium) Megathread v. 2

Because you put quote tags around all of it, and fucking selected it all. It's all in there. Learn how to internet.

LOL. For the record, cimetidine can be an extremely effective potentiator, in fact it arguably the best OTC potentiator/P450 inhibitor available.

However, just popping a couple of Tagamet isn't going to do shit. It takes VERY large dose, as it is a mild/moderate inhibitor by weight, and you need high plasma levels to achieve significant enzyme inhibition. You also need grapefruit juice for the full effect, as it not only COMPLETELY inhibits intestinal CYP3A4(which cimetidine isn't as good as) but in very large amounts, inhibits hepatic CYP as well. It also pushes the bioavailability of the cimetidine to 100%, making it an amazing combo.

But if used by itself, you have to start with at least a gram of cimetidine. If being used for multiple doses, you need to stack it in your system. The first day take 1.5-2 grams(divided into 2 or 3 doses, though always start with at least a gran your first dose) and then another gram the 2nd day.

For maximum effect, you drink at least a half gallon of WHITE grapefruit juice the first day, and if you can stomach it, drinking a full gallon in the first 24 hours yields the full effect.

Another 1.5-2 liters the second day. After this, it can take days for full enzyme recovery, so then you simply need to take maintenance doses the next few days. 1ltr of juice, and a gram of cimetidine a day is plenty. If continued indefinitely, you would need to take the full doses of cimetidine and WGJ once a week or, but after a few days, I would suggest going AT LEAST 24 hours without either, and preferably 48 hours, since eventually it reaches a max point of inhibition where it will take days to recover, and honestly your body needs a break from the cimetidine.

You could actually take WGJ every day, if you were so inclined, but it is unnecessary. However, taking extremely large doses of an H2 antagonist, that has both P450 AND PPG inhibitor properties, while also reducing hepatic blood flow, is not at all practical, which is why you always need a break. Really this whole "strategy isn't intended for every day use, it's for occasional EXTREME inhibition of opioids(and/or benzodiazepines) though a slightly less extreme version can be implied for chronic use.

(For example, my Cat(?) was prescribed 40mg methadone, and 3mg clonazepam, AND 10mg oxycodone per day(60 Roxi 5mg tablets) and was able to employ this very strategy to maximize the medication, since 40mg of methadone wasn't quite enough, and 10mg of oxy simply a joke. The clonazepam was fine, but since you can't inhibit one without inhibiting all 3, he had to take the hit...)
 
Taking cimetidine with poppy seeds is useless. The main component of poppy seeds(if you actually get unwashed seeds, and even then you would insane dose, and even more luck) is morphine.

Morphine is subject to phase 2 metabolism- that is, it is glucoronized by UGT and the like. It is NOT metabolized by P450 system.

And tonic water is always useless. It contains only trace amounts of quinine, which is just a mild inhibitor. And more to the point, studies have proven it has no effect; even when taken several days in a row.

Frankly, for WD relief, your better off with loperamide then trying to harvest alkaloids from fucking seeds.

No I was taking PST to get high and for pain relief. I just mentioned it to give homie some reference to tolerance. Shit, works for me. And, I definitely notice a strong effect from tagemt/tonic water. To the point where it prolongs onset, and increases duration. Maybe its my personal chemistry. Who knows. Im glad about it. YMMV.

But, I'm pretty sure i read somewhere information that contradicts what you said about the enzymes. It may have been just some thread with personal anectodoes, I don't remember. I can try to find it. Defintely not placebo. I take plenty of different things to tell whats goin on with my shit. I can defintely nod off that.

Most of the times that I take loperamide, pretty regualry, is for PAWS from benzo withdrawal, and to potentate the PST. I do it more than every so often, I was just tryna be tactful wit my whereabouts and whatnot lol.
 
And I also defintely have grapefruit jucie and the generic tagament and whatnot. Like i said, have no experience with methadone or pills.

Its possible that you've if you've tried PST with good seeds, and weren't able to nod, you prepared it wrong. Who knows.

You could also try valerian root and DXM or some sober time if you have a very high tolerance. I know that addicts who use very often sometimes have a tolerance that never resets.

But lets not get too off topic here.
 
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So here we go again I just took 18mgs of loperamide for about a 60mg a day oxycodone run..

I have been tapering slowly doing about 30mgs a day for the last 2 days I have work and a child as some of you kno with no time for 3 days to lay in bed..

Ontop of that I REFUSE TO BUY HEROIN I HAVE MONEY BUT REFUSE TO BUY DOPE..

I REPEAT I REFUSE TO BUY DOPE..

So let's hope this 18mgs helps
 
Thanks you, lolwhatzdrugs, then I should be in a lower dose before using loperamide to help withdrawal symptoms.

At what point might be what dose and what dose be aproppiate of loperamide?

For sure you should. That dosage is going to vary based on the person and what you think you can manage getting it down to. Like I said, there were only a few reasons I'd recommend loperamide and those were you getting kicked out of MMT or getting kicked out plus major suicidal ideations. It's quite the wonder for people wanting to get their lives back and not use full on opioids (or methadone which is a full on opioid/buprenorphine kind of) and are at lower doses - even 60mg of methadone might be ok, it probably isn't the safest to try and start a loperamide taper from such levels.

You can try and skip Sat/Sunday on the weekend, and taper up every 2 hours like 10 mg, and see if you can get to a point less than 100 mg of loperamide that makes you feel normal, or functional. You could even do this and store up your take-homes on the weekend so when you jump off you can have low doses of methadone as like a security blanket. I've read that some people have better chances jumping off stuff if they have a few doses sitting around so they know they don't have to panic if they feel bad all of the sudden and have to wait for things to kick in.

I was impressed with one guy in the methadone mega thread who mentioned being able to save up a large quantity so they could taper down to ultra low levels on their own (they had a few grams if I recall correctly) and they were at like 10-20 mg or less daily.

Those guys in that thread make me proud even though I don't know them, going from slamming dope or popping pills to being able to taper, and hang on to that quantity without thinking "I'll just pop a good amount of methadone for a buzz... this one time," and getting down to these really low levels. Man, I used methadone recreationally, if I had it then it would be game over, as soon as it hit my hand it would be gliding down my throat. I had only pills when I could get it, and I've tasted the liquid one time.... so maybe that might be some motivation to not take it.


Remember that if on loperamide it doesn't block out the high like methadone so if you're stressed out and good at convincing yourself that 'you're in control' when you're not, you might end up back at square one. This can also be dangerous if you've tapered correctly for awhile and think that you deserve a reward. MANY ODs happen here because people way overestimate their tolerance. Especially if it's smack they go back to, and they shoot it.

I'm sure he's fine.. He's been a smart advocate for lopermide since the last thread.. He knows his shit..

Thanks! I'm glad my efforts have been noticed!

"Ontop of that I REFUSE TO BUY HEROIN I HAVE MONEY BUT REFUSE TO BUY DOPE.. "

We're in the same boat, have money, could buy tar and get a gross high and feel guilty from spending the money... or not. I just couldn't take the guilt riddled, shit high that would result. I also just don't want to deal with the people required.

You're at 60mg and are going to taper it, or you've already dropped down for 30 mg a day, so that you were at 120 mg daily of oxycodone? That's not too outrageous, were you steadily and strictly on 120 mg or is that what you took to feel high? (120 mg daily would be a higher tolerance than taking 120 mg and feeling nice.

My tolerance would be a bit higher than that , I could probably take 150 mg to get high. When I take loperamide after not taking it for a a bit (I know not following my own advice, that I have a pretty good understanding of my dosage area is no real excuse, as little as possible is always better) I take a higher dose the first day and then less the second, what's odd is by the third it would have jumped up pas the second days dosage but not as high as the first day. In short, it seems that I don't have to take a constant dosage, I've just tried writing it down on an excel sheet the exact time and dose with calculations that will automatically add it up for the day so I can get a general idea of the dynamics of what I'm doing.

It ends up looking like this (in mg) 52, 20, 88, 38, 82, 20


I can't say that if someone threw a brick of tar at me that I wouldn't do any.


Again thanks!


To no one in particular:

If what I've said helps people not spend all of their money buying up street drugs or pharms and even make a major life decision and leave the scene completely which will translate to a better life, then I will be extremely happy! Also, if what I and others have said can talk someone opioid naive (or with a low tolerance) out of trying to get high off of loperamide whatsoever, and therefore make sure that no one's life is put in jeopardy like the poor woman who posted in this thread who lost her son because he read on reddit that this could get you high (and another BL member), then I will also be happy. That's right everyone, we've heard of 2 people who died on this website alone, and a quick search of the literature can find reference to a couple more. One from trying to get high with 0 tolerance from a dosage that most of us here using it for W/D relief would probably find decent, and another with a heft tolerance maintaining at a level that was too high, and drinking a lot of alcohol.


Loperamide is addictive as most people posting here should know. It's 'high' is very subjective as to what you feel. Most wouldn't call it a high - I sure wouldn't - but merely some subjective opioid feelings, and ones that are not particularly pleasant ones such as itching and constricted pupils - never feeling 'good'.

I'm here to promote only using it for tapering off of opioids, using it at a dosage as low as you can get it by titrating up, and then even then trying to endure the 10-20% bad that's left once you get to that point..

This is hard, and I'll personally admit that I usually fail at trying to do this because you can remove ALL of the symptoms at a high enough dose, but it's just safer to deal with the minor ones left over. If the W/D are from a short acting opioid like H/Oxy or the like, then you only have to deal with those 10-20% for a handful of days, and then you should be tapering it more rapidly because if you go for a few weeks taking it daily at a high steady dosage, you can go from HORRIBLE withdrawals that clear up in less than 10 days to (8/10 on the bad rating) to not as bad withdrawals (say 3-5/10) that last for 1-3 months. If you do it right and have will control you can have W/D that score a 1-2/10 and a with a 2 week taper schedule, be strong and be done with it. Dealing with the PAWS afterwards is a whole 'nother matter.

If you're on a longer acting drug like methadone/bupe and you're not at a reasonable dosage (generally more than 60 mg of methadone, but this is just a number I threw out there, less is always better) if you can taper, do it. It would take me more than 100 mg acutely of methadone to get high, and I could probably even handle a bit more, a much lower dosage of loperamide will make me feel 90%, like say 60-80 mg.

And I also defintely have grapefruit jucie and the generic tagament and whatnot. Like i said, have no experience with methadone or pills.

Its possible that you've if you've tried PST with good seeds, and weren't able to nod, you prepared it wrong. Who knows.

Dude, you come back here, and reply to my message, and then you wait a couple messages from other people and then you reply to me again. I can't even keep track of what you're saying, or at least trying to say.

No, it's not the seeds, even with the best of them, and 5 pounds of them, it just doesn't matter at a certain tolerance, and also at a certain amount of effort. Hence why I mentioned that you have no opioid tolerance, or a low enough one that you should really only be posting here for pharmacological interest, or if you're trying to control non-withdrawal related diarrhea.

Been there, done that, seeds suck, pods aren't even strong enough. I used to buy a box full of pods and nod out for a week or two, there's no way any poppy seeds are doing jack shit, unless people are smuggling opium into the US stuck to poppy seeds and you've found that supply.

No I was taking PST to get high and for pain relief. I just mentioned it to give homie some reference to tolerance. Shit, works for me. And, I definitely notice a strong effect from tagemt/tonic water. To the point where it prolongs onset, and increases duration. Maybe its my personal chemistry. Who knows. Im glad about it. YMMV.

But, I'm pretty sure i read somewhere information that contradicts what you said about the enzymes. It may have been just some thread with personal anectodoes, I don't remember. I can try to find it. Defintely not placebo. I take plenty of different things to tell whats goin on with my shit. I can defintely nod off that.


*sigh*

I love when people assert that subtle differences in subjective effects are definitely not placebo. Please go look up what a placebo is. Alexander Shulgin drank orange juice when he was being shipped to Britain for surgery from his US warship during WWII, and saw a crystalline powder at the bottom, and assumed it was a sedative, and it knocked him out and kept him out longer once he actually got the sedative. It was undissolved sugar that made him unconscious.

We know that W/D removal is not placebo due to objective consensus, and if you've ever been through heavy acute W/D you know when the pain and anguish is gone. You're talking about 'getting a little higher for longer.'

The fact that you say you're here to share this wonderful knowledge and then mention a bunch of shit that no one's really here for (increasing the blood plasma of loperamide, stopping that evil P-Gp from exporting it as quickly out of the brain... or wtf poppy seed tea). You can't get high off of loperamide, loperamide does not potentiate ANYTHING. You probably have such a little tolerance that you go around fucked up no matter what and think that EVERYTHING works.

Repeat, loperamide will only raise your tolerance more rapidly, it does NOT potentiate opioids. If you're shooting smack, no amount of loperamide is going to get you higher/use less smack, but take enough lope for long enough at higher dosages, and it sure will increase the amount of dope you need to get high.

Potentiators are things which either increase plasma levels/duration. Loperamide does not do this. People call diphenhydramine a potentiator, but they don't understand the difference between synergy, boosted analgesic effects, and potentiation. Read Lorne???'s post. Their shit = known well.

No matter how much this stuff is said, there will be those people who think I and others are dead wrong, that they can get a high, and we're just 'holding out on them so it doesn't get banned,' or something along those lines.

Those things def potentiate thru enzyme inhibition, and i mean a half pound good seeds I think would get most people very nice and high.

I brought that up because you mentioned opiate tolerance. So i answered your question. I think thats a tolerance. No tolerance would mean a small amount works. Lol.

You remind me of a friend who I need to buy a pair of gloves just for smacking him when he says something dumb.

I wasn't questioning ever whether enzyme inhibition was what worked, just said what you're doing was pointless. I never had a question for you. My question was "What is your point.... about anything? " I still don't really get it other than you use loperamide to potentiate opioids, and you're here to let us know your wonderful discovery!

"i mean a half pound good seeds I think would get most people very nice and high."

I don't think you even know what you're saying. Does it surprise you that the guy I replied to on 140 mg of methadone a day would not feel shit from a probably 8-10 pounds, much less a half pound? Does it surprise you that I wouldn't feel shit from 5-8 pounds? I don't think you understand the dynamics of what is going on, or you have a very cursory understanding that is going to get you up shits creek without a paddle. The fact that you mention this as a treatment for PAWS from benzo withdrawal is even more worrying. You're gonna have to start getting addicted to (please don't... I somehow felt this didn't go without saying) other shit just to treat your PAWS from benzo AND opioid withdrawal.

You're like the dude who got a cat to catch the rat, who got a dog to catch the cat, who got a wolf to catch the dog, and when all is said and done you have 40 fucking animals chasing each other, and you can't even remember what you got the Koala for.



My most concise post eva!
 
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No I was taking PST to get high and for pain relief. I just mentioned it to give homie some reference to tolerance. Shit, works for me. And, I definitely notice a strong effect from tagemt/tonic water. To the point where it prolongs onset, and increases duration. Maybe its my personal chemistry. Who knows. Im glad about it. YMMV.

But, I'm pretty sure i read somewhere information that contradicts what you said about the enzymes. It may have been just some thread with personal anectodoes, I don't remember. I can try to find it. Defintely not placebo. I take plenty of different things to tell whats goin on with my shit. I can defintely nod off that.

Most of the times that I take loperamide, pretty regualry, is for PAWS from benzo withdrawal, and to potentate the PST. I do it more than every so often, I was just tryna be tactful wit my whereabouts and whatnot lol.


Sorry, your "personal chemistry" doesn't change the pharmacodynamics of morphine. IT IS NOT, AND CANNOT, AND WILL NEVER BE METABOLIZED BY THE P450 system.

Cimetidine= P450 inhibitor (primarily CYP3A4 and 2D6, and to lesser extent 1A2

Quinine(in tonic water)= mild 2D6 inhibitor, though the dose in tonic water is ineffectual.

Sorry, but it's not increasing the duration of your high, any more than eating a Big Mac makes nod out. Although, I very much enjoy nodding out after eating my Big Mac. :)

I used to think people we're better off doing wtf ever, no matter how ineffectual, as long as it wasn't harmful, but in the end, what am I doing here if not spreading knowledge?

To be fair, cimetidine also reduces hepatic blood flow, but only in VERY HIGH doses, and in any case, that alone doesn't justify taking an H2 antagonist with can actually have quite unpleasant side effects, since it would still have no tangible effect on morphine metabolism, with acute dosing.
 
And awesome post LOLZ, agree with everything.

And I fucking LOL'd at the part about the koala!!!!!!!!
 
Sorry, your "personal chemistry" doesn't change the pharmacodynamics of morphine. IT IS NOT, AND CANNOT, AND WILL NEVER BE METABOLIZED BY THE P450 system.


Apparently it isn't, I didn't know and would have just assumed as most of the recreational opioids are substrates of one of them. Hepatic metabolism for the win!

And you caused me to google it which delightfully led me to

https://www.ncbi.nlm.nih.gov/pubmed/16301642
Human white blood cells synthesize morphine: CYP2D6 modulation
Human plasma contains low, but physiologically significant, concentrations of morphine that can increase following trauma or exercise. We now demonstrate that normal, human white blood cells (WBC), specifically polymorphonuclear cells, contain and have the ability to synthesize morphine. We also show that WBC express CYP2D6, an enzyme capable of synthesizing morphine from tyramine, norlaudanosoline, and codeine. Significantly, we also show that morphine can be synthesized by another pathway via l-3,4-dihydroxyphenylalanine (L-DOPA). Finally, we show that WBC release morphine into their environment. These studies provide evidence that 1) the synthesis of morphine by various animal tissues is more widespread than previously thought and now includes human immune cells. 2) Moreover, another pathway for morphine synthesis exists, via L-DOPA, demonstrating an intersection between dopamine and morphine pathways. 3) WBC can release morphine into the environment to regulate themselves and other cells, suggesting involvement in autocrine signaling since these cells express the mu3 opiate receptor subtype.

Man there are several pathways to get to morphine endogenously, apparently! The one that requires the P-450 pathway says: "CYP2D6, an enzyme capable of synthesizing morphine from tyramine, norlaudanosoline, and codeine,"

Does that mean that codeine is required since it says and instead of or? We can find all these pathways to endogenous morphine, but we can't figure out how to reset the receptor expression of opioids more rapidly. I'd be doing morphine keg-stands and then popping this miracle drug and sleeping it off... ;)
 
For sure you should. That dosage is going to vary based on the person and what you think you can manage getting it down to. Like I said, there were only a few reasons I'd recommend loperamide and those were you getting kicked out of MMT or getting kicked out plus major suicidal ideations. It's quite the wonder for people wanting to get their lives back and not use full on opioids (or methadone which is a full on opioid/buprenorphine kind of) and are at lower doses - even 60mg of methadone might be ok, it probably isn't the safest to try and start a loperamide taper from such levels.

You can try and skip Sat/Sunday on the weekend, and taper up every 2 hours like 10 mg, and see if you can get to a point less than 100 mg of loperamide that makes you feel normal, or functional. You could even do this and store up your take-homes on the weekend so when you jump off you can have low doses of methadone as like a security blanket. I've read that some people have better chances jumping off stuff if they have a few doses sitting around so they know they don't have to panic if they feel bad all of the sudden and have to wait for things to kick in.

I was impressed with one guy in the methadone mega thread who mentioned being able to save up a large quantity so they could taper down to ultra low levels on their own (they had a few grams if I recall correctly) and they were at like 10-20 mg or less daily.

Those guys in that thread make me proud even though I don't know them, going from slamming dope or popping pills to being able to taper, and hang on to that quantity without thinking "I'll just pop a good amount of methadone for a buzz... this one time," and getting down to these really low levels. Man, I used methadone recreationally, if I had it then it would be game over, as soon as it hit my hand it would be gliding down my throat. I had only pills when I could get it, and I've tasted the liquid one time.... so maybe that might be some motivation to not take it.


Remember that if on loperamide it doesn't block out the high like methadone so if you're stressed out and good at convincing yourself that 'you're in control' when you're not, you might end up back at square one. This can also be dangerous if you've tapered correctly for awhile and think that you deserve a reward. MANY ODs happen here because people way overestimate their tolerance. Especially if it's smack they go back to, and they shoot it.



Thanks! I'm glad my efforts have been noticed!

"Ontop of that I REFUSE TO BUY HEROIN I HAVE MONEY BUT REFUSE TO BUY DOPE.. "

We're in the same boat, have money, could buy tar and get a gross high and feel guilty from spending the money... or not. I just couldn't take the guilt riddled, shit high that would result. I also just don't want to deal with the people required.

You're at 60mg and are going to taper it, or you've already dropped down for 30 mg a day, so that you were at 120 mg daily of oxycodone? That's not too outrageous, were you steadily and strictly on 120 mg or is that what you took to feel high? (120 mg daily would be a higher tolerance than taking 120 mg and feeling nice.

My tolerance would be a bit higher than that , I could probably take 150 mg to get high. When I take loperamide after not taking it for a a bit (I know not following my own advice, that I have a pretty good understanding of my dosage area is no real excuse, as little as possible is always better) I take a higher dose the first day and then less the second, what's odd is by the third it would have jumped up pas the second days dosage but not as high as the first day. In short, it seems that I don't have to take a constant dosage, I've just tried writing it down on an excel sheet the exact time and dose with calculations that will automatically add it up for the day so I can get a general idea of the dynamics of what I'm doing.

It ends up looking like this (in mg) 52, 20, 88, 38, 82, 20


I can't say that if someone threw a brick of tar at me that I wouldn't do any.



Again thanks!


To no one in particular:

If what I've said helps people not spend all of their money buying up street drugs or pharms and even make a major life decision and leave the scene completely which will translate to a better life, then I will be extremely happy! Also, if what I and others have said can talk someone opioid naive (or with a low tolerance) out of trying to get high off of loperamide whatsoever, and therefore make sure that no one's life is put in jeopardy like the poor woman who posted in this thread who lost her son because he read on reddit that this could get you high (and another BL member), then I will also be happy. That's right everyone, we've heard of 2 people who died on this website alone, and a quick search of the literature can find reference to a couple more. One from trying to get high with 0 tolerance from a dosage that most of us here using it for W/D relief would probably find decent, and another with a heft tolerance maintaining at a level that was too high, and drinking a lot of alcohol.


Loperamide is addictive as most people posting here should know. It's 'high' is very subjective as to what you feel. Most wouldn't call it a high - I sure wouldn't - but merely some subjective opioid feelings, and ones that are not particularly pleasant ones such as itching and constricted pupils - never feeling 'good'.

I'm here to promote only using it for tapering off of opioids, using it at a dosage as low as you can get it by titrating up, and then even then trying to endure the 10-20% bad that's left once you get to that point..

This is hard, and I'll personally admit that I usually fail at trying to do this because you can remove ALL of the symptoms at a high enough dose, but it's just safer to deal with the minor ones left over. If the W/D are from a short acting opioid like H/Oxy or the like, then you only have to deal with those 10-20% for a handful of days, and then you should be tapering it more rapidly because if you go for a few weeks taking it daily at a high steady dosage, you can go from HORRIBLE withdrawals that clear up in less than 10 days to (8/10 on the bad rating) to not as bad withdrawals (say 3-5/10) that last for 1-3 months. If you do it right and have will control you can have W/D that score a 1-2/10 and a with a 2 week taper schedule, be strong and be done with it. Dealing with the PAWS afterwards is a whole 'nother matter.

If you're on a longer acting drug like methadone/bupe and you're not at a reasonable dosage (generally more than 60 mg of methadone, but this is just a number I threw out there, less is always better) if you can taper, do it. It would take me more than 100 mg acutely of methadone to get high, and I could probably even handle a bit more, a much lower dosage of loperamide will make me feel 90%, like say 60-80 mg.



Dude, you come back here, and reply to my message, and then you wait a couple messages from other people and then you reply to me again. I can't even keep track of what you're saying, or at least trying to say.

No, it's not the seeds, even with the best of them, and 5 pounds of them, it just doesn't matter at a certain tolerance, and also at a certain amount of effort. Hence why I mentioned that you have no opioid tolerance, or a low enough one that you should really only be posting here for pharmacological interest, or if you're trying to control non-withdrawal related diarrhea.

Been there, done that, seeds suck, pods aren't even strong enough. I used to buy a box full of pods and nod out for a week or two, there's no way any poppy seeds are doing jack shit, unless people are smuggling opium into the US stuck to poppy seeds and you've found that supply.



*sigh*

I love when people assert that subtle differences in subjective effects are definitely not placebo. Please go look up what a placebo is. Alexander Shulgin drank orange juice when he was being shipped to Britain for surgery from his US warship during WWII, and saw a crystalline powder at the bottom, and assumed it was a sedative, and it knocked him out and kept him out longer once he actually got the sedative. It was undissolved sugar that made him unconscious.

We know that W/D removal is not placebo due to objective consensus, and if you've ever been through heavy acute W/D you know when the pain and anguish is gone. You're talking about 'getting a little higher for longer.'

The fact that you say you're here to share this wonderful knowledge and then mention a bunch of shit that no one's really here for (increasing the blood plasma of loperamide, stopping that evil P-Gp from exporting it as quickly out of the brain... or wtf poppy seed tea). You can't get high off of loperamide, loperamide does not potentiate ANYTHING. You probably have such a little tolerance that you go around fucked up no matter what and think that EVERYTHING works.

Repeat, loperamide will only raise your tolerance more rapidly, it does NOT potentiate opioids. If you're shooting smack, no amount of loperamide is going to get you higher/use less smack, but take enough lope for long enough at higher dosages, and it sure will increase the amount of dope you need to get high.

Potentiators are things which either increase plasma levels/duration. Loperamide does not do this. People call diphenhydramine a potentiator, but they don't understand the difference between synergy, boosted analgesic effects, and potentiation. Read Lorne???'s post. Their shit = known well.

No matter how much this stuff is said, there will be those people who think I and others are dead wrong, that they can get a high, and we're just 'holding out on them so it doesn't get banned,' or something along those lines.



You remind me of a friend who I need to buy a pair of gloves just for smacking him when he says something dumb.

I wasn't questioning ever whether enzyme inhibition was what worked, just said what you're doing was pointless. I never had a question for you. My question was "What is your point.... about anything? " I still don't really get it other than you use loperamide to potentiate opioids, and you're here to let us know your wonderful discovery!

"i mean a half pound good seeds I think would get most people very nice and high."

I don't think you even know what you're saying. Does it surprise you that the guy I replied to on 140 mg of methadone a day would not feel shit from a probably 8-10 pounds, much less a half pound? Does it surprise you that I wouldn't feel shit from 5-8 pounds? I don't think you understand the dynamics of what is going on, or you have a very cursory understanding that is going to get you up shits creek without a paddle. The fact that you mention this as a treatment for PAWS from benzo withdrawal is even more worrying. You're gonna have to start getting addicted to (please don't... I somehow felt this didn't go without saying) other shit just to treat your PAWS from benzo AND opioid withdrawal.

You're like the dude who got a cat to catch the rat, who got a dog to catch the cat, who got a wolf to catch the dog, and when all is said and done you have 40 fucking animals chasing each other, and you can't even remember what you got the Koala for.



My most concise post eva!
Sorry I should have been more specific I tapered myself to around the 30mg mark 2 days before quitting.. I was at 60 and I tried to stay at 30mgs instead just before quitting to spread out my doses and the most out of what I had left
Looking like this.

Day 100- 30mg
30mg
15mg

Day 101-30mg
30mg

Day 102- 15mg
15mg
15mg

Day 103- 15mg
15mg

Day 104- 15mg
15mg

I ain't this is 100% correct but it's damn near close
 
I got 5 hours of sleep last night!!!!!!!!

I woke up feeling mad groggy this morning almost instead of lope last night I took trazadone, or ambien..

I tossed and turned a lil now I'm in the bath before work I don't feel too bad..

Energy shots... Shud be okay..
 
Sorry I should have been more specific I tapered myself to around the 30mg mark 2 days before quitting.. I was at 60 and I tried to stay at 30mgs instead just before quitting to spread out my doses and the most out of what I had left

What were you at at the peak dosage, two days ago and before? Is this scripted, or unscripted but for pain, or is this solely recreational? I noticed you wrote 100 days, but am not sure whether you wrote it like that just stylistically or this really is day 100+ (100 seemed too neat and round so I Asked :)). How long were you at the peak dosage and how long was your total use with no more than a few days break? Just curious, if you didn't mean to share all this stuff here and just a little support with the 18mg that's coo, just trying to get an understanding of what how much loperamide is called for.
 
It's Prolly been longer then 100 days or maybe just a Lil above since I last stopped or lowered my dose to almost nothing..

I use none scripted but was scripted originally for minor back surgery with pain still in my lower back..

Day 105 would have been yesterday with a final morning dose of 15mg oxycodone and then the 18mg lope at around 9:30pm

Peak dosage like I said wud prolly be at like 60mgs maybe a lil more like 75mgs tops a day..

Peak dosage lasted around a month with yes you are correct maybe a days break tops..
 
Lol. I don't have time to read and respond to all that right now, and there doesn't look lile there's anything to respond to? Were u having a discussion with me or to the thread? Seems a little personal
For the time being agree to disagree then
I enjoy PST and don't see how it or morphine could not have an effect. As far as the potentators, they work for me.
Maybe those are biased source results??

Lol. But I respect forums and citations and stuff. Its fun. Which fallacy in debate r u throwing around, I forget?

So y do u think the loperamide was making the poop too hard for my butt then????
 
you'll have to forgive me, I 97 percent of the time assume I'm speaking to the same person on multiple accounts or a script for knowledge when I see these sorts of things. And your response only looks like I can respond in fragmented questions.

I'm interested in your response. Id assumr were both on the same goal of displaying info for the public. U may be a social worker or addictions counselrr in real life so that's my bad homie

The other thing is that, ill edit so as to not derail the discussion;but your post has a lot of lexical and syntatic ambiguitu. Maybe you did that on purpose. But what u r trying to express isn't coming out how u expected I think.
its probably the medium, but it looks more like your describing a narrative of my thought process lol. I usually ignore things like this, but u sort of hit a nerve.

Maybe id need to see your inflection..
 
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I'm able to be on a computer now, So i want to give you my full thoughts sincerely. I'll have to make 3 posts and hopefully the mods can condense it if its too much of a deviation.

Do you realize how variable and overlapping those systems are in your body? You can't speak from such specific terms and limits. Just because you found one, or even three studies about a certain efficiency or finding doesnt mean thats an ultimatum of how that works. I dont need to get into detail, because i leave room for discussion, but its illogical.

I actually have a buddy who that kind of reminds me of. Dude did PST for awhile to get off dope. Would shoot his mouth off all the time about it because he was stealing bags from the place he worked. True story. And giving misleading and irresponsible information just like you about high doses. Dude ended up bouncing around on peoples couches/basements for years and it was a nuisance. I get loud and clear what your saying. But my point, is that ....a pattern of use doesn't need to be so careless. If you have no self-control, take some time to get your tolerance down. That was my point 100 percent, if that much morphine doesn't get you off, then you have a problem. Thats my opinion.

I don't think its safe to be giving out such biased and possibly dangerous information on a public forum....

And loperamide is an opiate. it responds in your body like an opiate. There's a lot of research about how it can pass the blood brain barrier with certain adjuncts and supplemts. It even says that on the first post here. But, if i were to say, this substance functions in this fashion, that has nothing to do with behavior; its a simple fact. It works that way. And i spoke that all people respond to chemicals in unique ways.

So, a tolerance to one, overlaps with the other.
 
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I've read your posts, and I just don't care anymore - or I didn't care to begin with, I just don't really know.

If you think my posts are ambiguous and disconnected, fine - whatever. I'll take this down as some sort of holy irony. People who show an understanding concerning pharmacology understand them and that's enough for me.


"And loperamide is an opiate."

It, on a most basic level, is not because it's fully synthetic. I'll let you ponder that and await the mindsplosion.
 
I'm able to be on a computer now, So i want to give you my full thoughts sincerely. I'll have to make 3 posts and hopefully the mods can condense it if its too much of a deviation.

Do you realize how variable and overlapping those systems are in your body? You can't speak from such specific terms and limits. Just because you found one, or even three studies about a certain efficiency or finding doesnt mean thats an ultimatum of how that works. I dont need to get into detail, because i leave room for discussion, but its illogical.

I actually have a buddy who that kind of reminds me of. Dude did PST for awhile to get off dope. Would shoot his mouth off all the time about it because he was stealing bags from the place he worked. True story. And giving misleading and irresponsible information just like you about high doses. Dude ended up bouncing around on peoples couches/basements for years and it was a nuisance. I get loud and clear what your saying. But my point, is that ....a pattern of use doesn't need to be so careless. If you have no self-control, take some time to get your tolerance down. That was my point 100 percent, if that much morphine doesn't get you off, then you have a problem. Thats my opinion.

I don't think its safe to be giving out such biased and possibly dangerous information on a public forum....

And loperamide is an opiate. it responds in your body like an opiate. There's a lot of research about how it can pass the blood brain barrier with certain adjuncts and supplemts. It even says that on the first post here. But, if i were to say, this substance functions in this fashion, that has nothing to do with behavior; its a simple fact. It works that way. And i spoke that all people respond to chemicals in unique ways.

So, a tolerance to one, overlaps with the other.

... I never said your PST wasn't working, only that your "potentiators" weren't helping and we're a waste if time. And no one knows how much morphine your getting from that, so no one can possibly have a problem from not getting off from some unknown amount of oral morphine harvested from seeds.

If PST works for you, great, but your wasting your time with cimetidine and, especially tonic water. I didn't even cite a study, I don't need too, because it is a FACT that morphine is rendered to phase 2 metabolism exclusively.


And what LOLZ meant was that, Loperamide is an opioid, not an opiate. Look it up.

You really aren't making much sense with anything else, so I'll leave you and LOLZ to it.
???
 
^Wheres your opiate tolerance at?

-Whens the last time you took loperamide, lolwhatzdrugs?

Maybe you missed the part about me being done with our 'discussion'. Though it was not really a discussion, me posting and followed by you wholly misinterpreting whatever and then ranting about something you clearly don't understand, each time in three or four completely disconnected posts.

Go take your clever, just ultra witty, self and make jokes about how 'So y do u think the loperamide was making the poop too hard for my butt then????' elsewhere. Discussing this stuff with your friends at naptime is a good recommendation, they'll either appreciate your exceedingly droll sense of humor, or they'll realize that you have grown apart.

When I can't separate whether you're a really good troll, or just wholly pathetic, I'm finished talking about anything. If you were serious and just appearing as a troll you have my pity, if you were trying to troll, then I don't really care, it's the internet. I honestly just can't really tell. There are those people who are just wholly ignorant and annoyingly misunderstood, and who also misunderstand everything to the extent that they seem like they're trolling because without any voice intonation or body language I really can't know.

I'll leave you and LOLZ to it.

Hold the door bud, I'm coming with you. I'm sick of learning just oh so much from his posts.
 
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