Not I, if you have a tolerance to opioids so does your gut. If you are constipated you're probably way over doing it, gonna develop a serious loperamide dependency, and be chained to the stuff for a very long time. It is not a miracle, but it is a miracle if you don't want methadone/bupe and you can deal with the incomplete opiatedoutnessd.
(We don't use the term SWIM or anything like that IE My pet what the fuck ever - we know it is YOU, and not only that, you're taking a legal maintenance treatment...)
It voids all of the terrible aches and pains, the horrible anxiety, in short the most terrible and soul crushing aspects of acute opioid cessation. Whether this is due in total to the PNS effects, or it cross the BBB and having central effects has not been completely documented, and is up for discussion IMO. If it had central effects surely you'd feel some sort of contentedness that
regular opioids provide and not merely relief from withdrawal. Many would disagree with my assessment, but we're generally in agreement that it 1. stops WD 2. it is
not recreational.
Yes it can be taken with clonidine. If you cold turkey at 140 mg, I would be shocked at the dosage of loperamide you would probably need. This is not a particularly good plan, and tapering methadone to a doable level and then tapering loperamide would be preferable in my opinion. I can't condone trying to titrate up loperamide to cover 140 mg of methadone on a chronic basis. The only way I could condone it is if you were thrown out of a methadone program at that level, have no option to move downwards, and are suicidal with clonidine and other drugs taken as needed for an acute period (like benzos) not covering the bare necessities, and a lower dose of loperamide to take the most horrible edge off.
Remember, if you switch to loperamide you will not receive near the same 'coverage' or feeling of opioid contentedness that you currently receive from a full on mu agonist in the CNS like methadone does - I personally consider methadone recreational if not taken chronically. That it also doesn't block a high from other 'real' opioids like heroin/morphine and so on, this means that if you're not completely sure of yourself it won't be hard to use an opioid to get high like it currently is.
Remember many addicts are
very sure of things they shouldn't be (IE I'm not addicted, I can control it, I can chip and not get back on the wagon). The ability at self deception concerning this class of drugs is so tremendous that it is hard to believe until you personally experience it and after that it is now too late. You move on to the last one I mentioned after you get off them entirely, usually induced by PAWS. It is the one which you probably started with, it's quite cyclical: "I can use responsibly/ I can can chip and not get back on them like I was before." A vicious vicious, sometimes lethal, completely controlled by both positive and negative reinforcement cycle. Loperamide can be easy to taper since there is no high you can authentically chase like you can even with bumping up methadone when you're at certain doses, imagine if you took 250mg (of methadone), there would be some feeling of a 'high' I imagine even if not considered recreational like morphine. Doubling loperamide after being at a stable dosage that removes WD will do nothing, might make you puke a BUNCH. I've only puked once from loperamide doing something along these lines when I started experimenting with it and was so impressed by it's ability to remove WD that I ventured into stupid territory and learned my lesson.
I threw up every 10-15 minutes for two hours, drinking water just so I had something to puke and not dry heave which would occur if I didn't. The vomit center of the brain would be relieved by the vomiting and I'd feel relief, it would reset and the blood levels of the lope absorbed would shock it into another set of puking. I was lucky I did no damage other than to my poor teethies (that I'm aware of, and even to my teeth is just an assumption but probably did a little for sure).
In conclusion (TL;DR) I think that it would be best to taper to a much lower, definitely sub-100 mg level before you attempted to taper with loperamide. When you do this it is essential to take the minimal amount of loperamide necessary to make life bearable as it is still an opioid with a long half life that will also have it's own WDs. It would only be a true miracle drug if you could take it, remove WDs, and it itself would not have WDs. Opioids would then be considered fairly innocuous short of acute ODs - this is not the case.
Edit: I'd direct you here (
http://www.bluelight.org/vb/threads/601690-Methadone-Mega-Thread-and-FAQ-v-2-0?p=12410901) to discuss tried strategies for reducing methadone dosage / getting off of it. I'm sure there are people there who have gone the route I described (reducing methadone to lower levels - sub 30 mg would be great, the less the better - and tapering loperamide from there).
, short of the MPTP the prodrug of MPP+ which is the dopamine destroyer, I'm not sure anything is linked and known definitively to kill dopaminergic receptors in vivo, someone correct me if I'm wrong. I know there's some speculation about aluminum, we use it in drinking containers and all kinds of stuff. At least in soda cans there is a plastic liner inside, but I don't think there is on the lid, etc, how much aluminum is absorbed by the body, and how long does it take to be cleared, and is there in vitro studies of human cells and dopamine receptor destruction?
