I Like to Draw Pictures of Random Molecules

[blueberries]

It would tautomerize to a phenol.

What if it were already a phenyl? Like this:

 

[sekio]

That's a Texas carbon you've got there. Carbon won't accept 5 bonds.

 

[DL-ark]

What if it were already a phenyl? Like this:

As sekio said, carbon wont accept 5 bonds. I think an aldehyde group is best for using the double bond.

 

[Jabberwocky]

he said 5 bonds

 

[black53]

constrained tryptamines, based on http://en.wikipedia.org/wiki/RU-28306 aka constrained dmt:

constrained dmt:

constrained det:

constrained dpt:

constrained met:

constrained mipt:

constrained dipt:

constrained amt:

constrained mpmi:

constrained whatever this would be called:

 

[blueberries]

Someone sent me a Hydrocodone analogue with some phenyl ring hanging off the end so I altered it and made this:

I'm expecting an opioid PCE metabolite with a PPOM-esque main structure. IMO it's a complete clusterfuck but make of it what you will!

PS: The fluorine is for style

 

[blueberries]

constrained dpt:

I saw a bug that looked like this the other day. It was menacing. I imagine the same for the compound!

 

[blueberries]

As sekio said, carbon wont accept 3 bonds. I think an aldehyde group is best for using the double bond.

Shit, yeah, I kinda forgot about that!

 

[black53]

2c-c analogues:

2c-c:

tcc-2:

2c-c-5eto:

2c-c-5thio:

2c-c-fly:

2c-c-thiofly:

bk-2c-c:

bh-2c-c:

bm-2c-c:

bk-2c-c-fly:

bh-2c-c-fly:

bm-2c-c-fly:

 

[black53]

5-methyl-mda analogues:

5-methyl-5-apb:

5-methyl-5-apdb:

5-methyl-5-mapb:

5-methyl-5-mapdb:

5-methyl-6-apb:

5-methyl-6-apdb:

5-methyl-6-mapb:

5-methyl-6-mapdb:

5-methyl-mdma:

MMDA-2 analogues:

2-methoxy-5-apb:

2-methoxy-5-apdb:

2-methoxy-5-mapb:

2-methoxy-6-apb:

2-methoxy-6-apdb:

2-methoxy-6-mapb:

2-methoxy-6-mapdb:

@blueberries:
lol :D

 

[sekio]

What is this, combinatoric chemistry month?

 

[black53]

something like that

 

[blueberries]

5-methyl-mda analogues

Vs.

MMDA-2 analogues

5-sub-MDA analogues are much lower potency than their MMDA-2 and MMDA-3a counterparts, so go for those instead. In fact all the hype surrounding 5-MMDA was in fact caused by either 2 or 3a-MMDA, as what tends to happen with the 5 positions is they greatly reduce potency (See MMDA & practically all 5-Me-MDA reports). They wane to act towards a mescaline type compound rather than a 2C type compound (also just looking but where is Shulgin's final TMA? At 6, 5, 4, opposite the a-Methyl).

Also looking at METHYL-MMDA-2, adding an N-methyl bond would eliminate most of it's activity, it truly is a wonder how MDMA worked out so well, I'd have thought it would be much stimmy-er to be honest!

DMMDA & DMMA-2, too, would wok fairly well. Another thing to look at is Ethyl, Isopropyl, Vinyl, Ethenyl, Ethynyl, 2-Methyl-Ethynyl, Methyl-trideutero, Nitroxide, Thioxy and possibly Fluorine bonds at these points (but only at 3a (and, hesitantly, at 5), as that Methoxy at 2 is fairly essential and cannot be tweaked with too much, due to stearic hinderance). Basically anything that isn't too bulky and can be able to be broken fairly easy in vivo (so not really halogens, although I'm still unsure over fluorine (that thing can go anywhere!)).

There's just so many analogues in the MDA pile it's ridiculess, and I'm willing to bet each of them would be amazing.

 

[black53]

:D

I'd like to see those constrained tryptamines, 2c-c-fly and tcc-2 too

And some more:

2c-al

2c-mal

3c-al

3c-mal

dom dragonfly

6-tfm-6-nor-lsd

6-mal-6-nor-lsd

various fluorinated mpa versions for example:

various difluoroamphetamines/methamphetamines, for example:

d-threo-iph:

lisdexfluoroamphetamies, for example lisdex2fa:

eph reverse ester:

iph reverse ester:

all variations on http://imgur.com/a/vYJrY

 

[blueberries]

Ok, I'm not going to draw out each one but you can see where I'm coming from, hopefully!

These are my notes on Tryptamines & Phenethylamines:

TRYPTAMINES


N, N, xx-Trypamines :

DMT
MET
MiPT
MPT
MBT
MALT
DET
EiPT
EPT
EBT
EALT
DiPT
iPALT
DPT
PET
PiPT
PBT
PALT
DBT
MBT
EBT
iPBT
PBT

More xxT's include:

Ethenyl (V)
Ethynyl (Y)
2-Methyl-Ethenyl (MV)
2-Fluoro-Ethenyl (FV)
2-Chloro-Ethenyl (CV)
Ethyl-Dimethy (IB)

Therefore:

MVT
EVT
iPVT
PVT
BVT
ALVT
MYT
EYT
iPYT
PYT
BYT
ALYT
MMVT
EMVT
iPMVT
PMVT
ALMVT
MFVT
EFVT
iPFVT
PFVT
BFVT
ALFVT
MCVT
ECVT
iPCVT
PCVT
ALCVT
DiBT
MiBT
EiBT
iPiBT
PiBT
ALiBT


Halogens:

DFT
MFT
EFT
iPFT
PFT
BFT
ALFT

Then all substitutions inbetween using V, Y, MV, FV, CV, iB:

VYT
VMVT
VFVT
VCVT
ViBT
YMVT
YFVT
YCVT
YiBT
MVFVT
MVCVT
MViBT
FVCVT
FViBT
CViBT

Substituted Tryptamines (using same N, N substitutaions as previous):

4-HO-xxT

4-AcO-xxT

4-Propioniyl-xxT

5-MeO-xxT

4-HO-MPMI - alpha-pyrrole n, methylT,

4-HO-xPMI with N-Substituted attachments.

4-Fluoro-xxt??

4-HO,5-MeO-DMT-5-HemiFLY: furan ring from 5-Meo to 6 position

4/5 benzofuran-xxT - like 4,5 MDO but ABPish. 4=potent, 5=psychedelic

6-HO-xxT - Metabolised from 4-HO-xxT

4, 7 DiMeO 5-Fl/Cl/Pr/etc xxT **

4,5,6 - Halogen - xxT - Halogenated T

5-Ethoxy-xxT

5-Ethyl-xxT

4-HO-xEFT N - 2, fluroethyl-

4-HO-DTFMT - ditrifluoromethyltryptamine

DTFMT - Ditrifluoromethyltryptamine

7-TMT - 7 position could be 'magical' position along with 5

4, 5 MDO-xxT - MDMA Tryptamine

5, 6 MDO-xxT - MDMA Tryptamine

7-MeO/HO/Fl/Cl/Br/I/MeS-xxT - 4 position in phens

2-Me-xxT - weak tryptamines

Mexamine - Endogenous dream compound - 5-Me-T

5-CT - Nonselective, high affinity full agonist at HT1A, B, D, 5A and 7 receptors, as well as at HT2, 3 and 6 with lower affinity. Negligible affinity for HT1E & 1F. It binds strongest to HT1A however.

PHENETHYLAMINES

4-SUBSTITUTIONS:

Methyl
Ethyl
Propyl
isoPropyl
Butyl
Methenyl
Ethynyl (YN)
Propynyl (PYN)
Ethenyl (IV)
Propenyl (PIV)
isoButyl
Carboxy (COOH)
Cyanide
Amine
Ethylamine
Propylamine
Cyclopropylmethyl
Pyrrole
Phosphorous
Benzyl
Napthyl
Morpholine
Allyl
Methallyl
Ethallyl
Propallyl
Thio-Alkyl
Di-Alkyl
Thiodialkyl
Oxo-isopropyl

Fluorine
Chlorine
Bromine
Iodine
Selenium
Tellerium
Fluoromethyl
Fluoroethyl
Fluoropropyl
Chloromethyl
Chloroethyl
Chloropropyl
Bromomethyl
Bromoethyl
Bromopropyl
Iodomethyl
Iodoethyl
Iodopropyl
Difluoromethyl
Difluoroethyl
Difluoropropyl
Dichloromethyl
Dichloroethyl
Dichloropropyl
Dibromomethyl
Dibromoethyl
Dibromopropyl
Diiodomethyl
Diiodoethyl
Trifluoromethyl
Trifluoroethyl

3,4/4,5 DiAlkyl
3,4/4,5-Bnb,
3,4/4,5-Methylenedioxy
4/5/6-Benzofuran


I hope everyone can make sense of this and apply it to various Tryptamines and PEA's

This is the big list and can be tinkered with in anyway possible.

This is but the beginning, we can use these alkyls and halogens to produce multitudes of compounds.

The structure soon turns into art and the greatest compounds can be made from all of these suffixes.

Have Fun!


Oh! And by the way the total number of psychedelic compounds utilising such substitutions are over 50,000. The key is to find that one chem that could be a game changer!

 

[black53]

Some of these were already made actually and are even available for sale..

 

[blueberries]

Some of these were already made actually and are even available for sale..

Yep. This is the full line-up of all substitutions. These can be applied anywhere, in the right places of course. On the whole though this is the entire list of substitutions that can be made at appropriate positions. Shulgin (RIP) made but a few of these. T & P structures are now turned into an artform, do what you will with the suffiixes and have fun.

For drawing random chems this is the database. You can go anywhere and add what you will to everything, Indole and PEA combined. So what's next?

Somewhere in the thousands of possible structures, there are golden ones. Find them, test them, distribute them.

The world is your oyster.

 

[black53]

>So what's next?
Target other signaling systems? Other modes of action ( activity enhancers for example )? Skip the receptors/neurotransmitters entirely and target the upstream effects they produce?

 

[blueberries]

Or directly implant nanobots to agonise/antagonise the receptors to a specified affinity so we can make our own cocktail of drugs to our own personal needs.

Whichever first, I guess, and at the rate that technology is evolving, it certainly could be the nanobots!

 

[blueberries]

I tried to combine the structure of Delorazepam with Ketamine, simply because I wanted it to be named DeLoramine; the closest thing I could think of to DeLorean.

So this is DeLoramine:

I chose Ketamine because hopefully you'd go back to the future with it!

___________

For good measure: 3C-PO -

___________

And of course, Ar2-D2:

___________

I'm in a weird mood tonight..

___________

THIS MUST STOP!