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LSd similar to opiates???

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fizzymk

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Dec 18, 2013
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I was looking online about Peyote, Ive never done it, but for some reason, I got to thinking about it and decided to google it, well, eventually I came across info about LSD naturally, and while Ive done alot of this back in the early 90s, I did not know it was good for pain relief, I actually cannot remember if it took pain away or not, been a long time since Ive used it and Im not sure I would use it at my age, even if I had it.

Wiki says it is longer acting than most opiate painkillers and seems to do a better job at taking pain away, Just wondering if anyone else has heard of this or know if its true or not?
 
What? ...no lol. It's like the complete opposite in psychoactive effects. I've read it has anti-inflammatory effects like asprin, it wouldn't be an effective painkiller though.
 
TheGrasshopper said:
I find acid to be an amplifier. So no, I can't see how this would work. I would assume the pain would be even more noticeable.
I have used it effectively as an anti-depressant.
Half a hit a day, keeps my worries at bay..
Click to expand...

as far as I know from experience and what I think I recall having read that an LSD dose needs to be doubled if its being used on a daily or on a regular basis with only a few days between each use. I remember times in the late 80's when I'd go to several night runs of Dead shows and if I had wanted to drop for each one then I'd have to plan it as if I had taken 500 mics the first night then I'd need 1000 the next to reach the same level and 2000 the night after that etc. etc. Still wouldn't completely have the same magic no matter what dose I took like it did on my first night or two. I'd definitely be tripping hard but that sense of awe wouldn't be as prevalent if it was even there at all.
You say a half a hit a day works for you as an anti-depressant but I'm wondering if that's possibly just what you believe is happening but in reality isnt occuring at all. I'm not saying this as an accusation because I could be wrong. I'm more curious if maybe the dosage doubling only applies to its psychedelic properties but not the potential ones it may also have as an anti-depressent. I'd hate to see it get wasted by you since it's such a rarity in my neck of the woods. lol still,if its working I guess that's what matters!
 
I don't know about LSD, but I know LSA via HBWR seeds as well as P. cubensis are excellent analgesics...in a mind over matter way.
I have read studies that show LSD to more effective than morphine for cancer pain...but no, it is not related to opiates.
The painkilling properties of LSD and shrooms are due to mind over matter..."if you don't mind...it don't matter".
 
I've read before that LSD has some analgesic effects and I tend to agree with that statement. I generally feel a sort of numbness (if it can be called that, it's a strange sensation) as if I could stub my toe and not notice. Combine that with the (for me) absolutely euphoric body high and I can see why it's said to be analgesic. However, I'd guess that a dose high enough to be an effective analgesic would also be high enough to result in a psychedelic trip, king of impairing it's value as a pain killer.
 
There are many different ways to go with this thread, and they are all correct. I'll start off with this one. In taking acid for anti depressant, analgesic, or other reason, how about the tripping part is simply the side effect. I have seen reports discussing the similarities to beta blocking drugs, like propranolol.
 
LSD can ease some discomforts and intensify others. It's not similar to opiates. Some research has been done on using LSD to treat very specific kinds of pain like cluster headaches, but not (AFAIK) as a general-purpose painkiller.
 
Agreed. Let's take it a step further. If LSD were say in a time released transdermal patch like fentanyl, with similar dosages, then it could be safely used in clinical trials. They can easily dial the dosage down to one mic, and titrate up from there.
 
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In tests on animals Amphetamine is as potent a painkiller as Morphine, so it wouldn't surprise me that LSD is a good painkiller too. It definitely eliminates my back pain, which is something weaker painkillers like NSAIDs don't do, opiates do a good job of it, most psychedelics do too.

Doesn't really make LSD similar to opiates though, there are so many different types of painkillers out there, and many of our recreational drugs are painkillers too, even the ones you wouldn't expect.
 
Psychedelics like LSD can have dissociative effects and also the euphoria could counter pain sensation somewhat, but both of those effects aren't reliable for pain management as far as I know. As said by another poster, a trip has amplifying qualities and what gets amplified depends on the set and setting and how the trip is working out mentally and emotionally. If you feel wonderful about experiencing say spiritual freedom or visuals or acceptance of both good and bad things, that can minimalize how any occurring pain is felt with suffering, but on the other hand if the trip isn't going so well and you are anxious, confused and what have you... I can tell you from experience you can become amazingly sensitive to a wide range of 'sensations' including lots of physical ones like pain.

In other words, it is unpredictable for the purpose of pain relief... but I do recall there being some link between pain killers and LSD, just forgot what it is I'm afraid.

@ JG: makes me wonder if part of analgesia is achieved via dopaminergic effects of opioids and not simply just via MOR. MOR affinity alone has been proven not to be the sole tell for analgesic potential... not sure if that is an affinity vs. efficacy thing or a complex downstream signal transduction difference like with serotonergic psychedelics, or like I just said: pharmacological action involving dopamine that perhaps yields signals telling the brain that you feel fine, good, more than good, at least not in pain... and as such overrules or inhibits pain signals indirectly?
Sooo, wondering really.
 
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