The only significant worry would be cocaine's cardiotoxicity. Cocaine isn't neurotoxic, it seems that most if not all DARI's are non-neurotoxic, however it does do a great deal of down-regulation, but is very reversible with cessation. I honestly would never touch cocaine though due to its strain on the heart though.
OT: With no experience amphetamines are by far superior to any stimulant in every way shape and form. However even with sparse use tolerance and side-effects become more apparent to the point that the drug sucks. I did manage to get a prescription for Desoxyn back in 2010, but hardly got a taste for it due to anxiety.
As of now Tobacco is the best stimulant. Subtly euphoric, stimulating yet relaxing, and has virtually no crash.