Heya :D
1. No, not especially - it may just have extra strong effects on your judgement and inhibitions, and also dissociative effects. However it is generally not recommended to mix drugs when you are trying one for the first time. Also if you ask me, it is worth experiencing a clean 2C-B trip since it is very tactile and aesthetically enhancing. Adding something like alcohol can really make it more 'dirty' subjectively which would be a shame. Not a horrible combination to consider at a later point when you have much more experience with 2C-B but wouldn't suggest it right away.
2. Do you mean cardiotoxic or perhaps vasoconstrictive? Cardiovascular means merely pertaining to the heart and bloodvessels. Anyway 2C-B is still a phenethylamine and a sympathomimetic drug, it increases heart rate and blood pressure but no it is not associated with side-effects NBOMe compounds and amphetamines and DOX compounds are associated with, like issues in the extremities and coldness, etc.
3. I really don't think so, no.

2C-B seems to be quite benign on the body.
In what form will you be getting the 2C-B? Is this going to be your first psychedelic experience? Why did you ask question number 1? Are you planning on taking the edge off (anxiety) with a beer or is it more like you are planning on going to a social event / party and want to use it there? It is important to consider what setting you will use it in first so that it is hospitable to the positive effects you are seeking and expecting.