Opioids Pre-Dosing With Loperamide To Possibly Slightly Potentiate My Opioid of Choice.

[Thomas29]

I know the Consensus is that taking some Loperamide before taking some Oxycodone for Examplpe to Possibly get me Higher. BUT THAT IS NOT MY QUESTION! WHAT IS MY QUESTION IS THIS!

I know if I use too much Loperamide it will Block other Opioids like Oxycodone from getting Me High since the Receptors are Saturated by Loperamide how much should I take I am thinking 8mg to 16mg of Loperamide before Dosing or is that too much what would you Recommend and my SECOND IMPORTANT QUESTION I REALLY WOULD LIKE ANSWERED. Is how Long Exactly does Loperamide take to come into Full Effect is it Similar to Methadone where it takes up to 4 Hours to Achieve the Full Effects of the Drug Thank You for your Time and Answers it is much Appreciated.

 

[muskolo]

I know the Consensus is that taking some Loperamide before taking some Oxycodone for Examplpe to Possibly get me Higher. BUT THAT IS NOT MY QUESTION! WHAT IS MY QUESTION IS THIS!

I know if I use too much Loperamide it will Block other Opioids like Oxycodone from getting Me High since the Receptors are Saturated by Loperamide how much should I take I am thinking 8mg to 16mg of Loperamide before Dosing or is that too much what would you Recommend and my SECOND IMPORTANT QUESTION I REALLY WOULD LIKE ANSWERED. Is how Long Exactly does Loperamide take to come into Full Effect is it Similar to Methadone where it takes up to 4 Hours to Achieve the Full Effects of the Drug Thank You for your Time and Answers it is much Appreciated.

I know for me, at least, loperamide didn't block my high. I can't speak to oxycodone because I only use kratom now. Generally, I use about 10-15 grams a day but after taking a week off using only loperamide to mitigate w/d, 4 grams actually did the job albeit nothing out of this world. Still, that's a 1/3 of the dose I usually have to take.


As for it potentiating anything, I've only read anecdotal stories and couldn't tell you. The receptors, AFAIK, are only saturated in the stomach and spine not the brain.

Not a fantastic answer, but hopefully someone can better give you a better answer.

 

[Halif]

Hey Thomas,

Have you used loperamide before? Different people will give you different dosage recommendations based on their own personal experiences, but you're thinking of starting with 8-16mg? I'd actually suggest even lower. For potentiation, I've found as low as 4mg to be effective BUT it does take 3 to 4 hours to come into full effect.

I suggest starting low because lope can cause intense constipation if you're not used to it, and it is actually a very potent substance that lasts a very long time. So it might be better to be super cautious in case you get more effects than you bargained for.

Also, lope is in fact very addictive indeed, and has some diabolical withdrawals if you get into a habit with it. Of course, having a very long half life means it also has a torturously long withdrawal experience, too.

Less is more with lope. Don't underestimate it.