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Nootropics The Big & Dandy Nootropics Thread (Stack 2)

Interesting, I hadn't heard of this IDRA.

I also hate DMAA... nasty, strong stimulation, it really made me feel like nervous, jittery ass.
 
Have any nootropics been found to be efficacious in helping relieve major depressive disorder?
A friend of mine offered me a large amount of choline and piracetam but I gave yet to take him up on the offer as I'm relatively uninformed on the subject.
 
I was quite depressed after college, though I think largely circumstantial. But I took piracetam, choline, and hydergine (I think the hydergine helped the most with the depression), and it helped a lot. I like piracetam, I like going on runs with it and then stopping for a while. It adds a subtle ease to your brain activities. Choline is very good for your brain. Lecithin is also good.

Phenibut isn't really a nootropic but it can create a very nice day-long euphoria. It can develop dependence though in my experience I seem to have to use it continually for long periods. One time I used it daily for a year and coming off it was horrible, the most insane anxiety ever, for about a week. Even worse because I didn't expect it.
 
^Hydergine is definitely my favorite nootropic.

I've combined it with psychedelics and MDMA and it seems to make them produce less of a hangover, I would recommend it.

The hardest roll of my life I took 4.5 mg hydergine and ate an abnormally large amount of dark chocolate with a high percentage of cocoa, then I ate a half hit of acid, followed by the second half an hour later then 270mg of MDMA and I had no hangover the next day after restful sleep.

I also combined noopept with 1/3rd of a gram of mushrooms and it produced some visual activity in class haha
 
Noopept is a very potent nootropic, not a racetam but very similar if I'm not mistaken.
I have quite a bit of the stuff but have quit using it.
I kind of noticed a mental boost but nothing that I couldn't also just pass off as placebo.
I need to start trials with it again
 
i am currently taking tabs with 20mg noopept and 250mg citioline in them twice daily and have noticed a difference in overall calmness and focus and am quite happy with the effects so far. but now i feel i wanna throw something else into the mix, can anyone recommend a good add on that would go well with these?

i been looking into phenibut, would this be a good addition to my stack?
 
@Deano: phenibut does not feel like a classic nootropic to me but it does make me feel like even difficult days progress rather effortless. However this is not due to cognitive enhancement but medium-level anxiolysis (it helps battle anxiety), not all kinds of anxiety IMO, physically based anxiety less so (probably because these are more GABAA related) but social anxiety dissipates like snow in the sun. Phenibut acts primarily or only on GABAB. I say medium-level because it is quite noticeable and at the border of having to call it a drug but tolerance and withdrawals are considerably less hardcore than with benzo's. Still: watch out.

It is hard to recommend other supplements for you if you do not describe what you are looking for. Generally I quite dislike suggesting drugs or other compounds out of the blue on this forum. Doesn't feel quite right. ;)

@Xork:

Link to noopept thread: http://www.bluelight.ru/vb/threads/663162-Nootropics-Subthread-Noopept-(GVS-111)

It's a tripeptide which is chemically speaking generally unlike the racetams but the prolyl linkage vaguely reminds of the functional groups racetams have in common. Wiki does say that it is derived from the racetam family but I'd say it is pretty different. It is not an AMPAkine like the racetams and many people do not get as noticeable acute effects as with racetams. On the other hand it does stimulate neurotropic growth factors which I think are supposed to encourage the formation of new neurons. But it is difficult to say if extra neurons help with anything in healthy humans. I guess if you are in a period where you are learning a lot there are different connections formed or consolidated in the brain and common sense of the layman would probably say that such a drug would support all that. Whether such things help with mental illness is really damn iffy, progress like healing from CNS damage may be rather indifferent and it would require certainty that positive changes are being made. Nootropics might not help at all or even make matters worse, who knows?

Noopept is not the only nootropic peptide, there are also selank and semax (all are of Russian origin by the way) and these latter two I am very interested in. They are more complex and harder to make and the high price does correspond with that. However they are supposed to have powerful abilities that mend the brain for example after serious stress.

It is worth noting that as these are peptides they are broken down in the gut so you must at least ingest them sublingually. But injecting is probably loads better. I think you need to reconstitute them in an acetic acid solution. One day I may try this with noopept but I can't find it >_<
Noopept tastes freaking musty by the way!

Some extra supplements arrived today: I have CoQ10 powder which is many times cheaper than gelcaps. But I am going to have to make an oil solution otherwise it won't absorb very well.

(By the way I just opened it and it is a very beautiful bright orange color and it smells and tastes pretty nice!!)

Here is the recipe for Coenzyme Q10 in oil (I'm using olive oil):


NSFW:

1) Heat 16 fluid ounces of coconut oil to between 150°F (65°C) and 158°F (70°C) in a sauce pan on the stove.
2) Add 25 grams of Coenzyme Q10 powder. The powder will melt instantly and dissolve into the hot oil.
3) Stir for one minute.
4) Remove from heat and allow to cool to between 80°F (27°C) and 90°F (32°C).
5) Pour mixture into a rigid plastic or glass resealable food storage container and allow to cool to room temperature.
6) At below 76°F (24.4°C) coconut oil will turn solid, and that is fine.
7) The blended oil should be kept sealed but refrigeration is optional.
8) A level half teaspoon of this oil, liquid or solid, will net approximately 130 milligrams Coenzyme Q10, which is in the usual range of a commonly recommended serving size for this most bioavailable form of CoQ10.
9) Do not exceed a serving size of 1 level teaspoon (260 milligrams) of the blended Coenzyme Q10 coconut oil per day, except under the care and supervision of a physician.
10) If possible, take your CoQ10 with a fatty food at meal time. You may spread it on toast or add it to any food as you would if it were butter.

Also got phosphatidylserine because it has made me feel more adequate in the past which is not something I can say for a whole lot of supplements / noots.
Milk thistle to help my possibly flabbergasted liver.
Creatine which I just ran out of but that is not a nootropic.
And I took aniracetam and choline which I still have plenty of. I love aniracetam! For me it is the best out of racetams I tried. Oxiracetam and pramiracetam are a bit weird for me and piracetam is just less effective / potent. I don't know about nefiracetam or coluracetam but one of them might be hazardous for the testicles (!), at least in dogs. But I guess you have to make sacrifices if you want your dog to learn your tricks. ;) And it saves money for the neutering.
 
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i am using nootropics mainly because i'm learning to drive but also i have started new job so i want to increase my ability to learn new things quickly. i have no anxiety or depression issues, i like to use mdma and speed evey now and then and drink most weekends so would like to know how certain noots effect these.

i been using noopept for a few weeks now but only drank alcohol during that time and cant say i noticed any difference from drinking without.

i looked up Phenibut and seen that there can be bad withdraws from it so its kind of put me off a bit but might just get it to use on the odd day when needed instead of daily use. oxiracetam sounds like a good one to throw in with the noopept + citicoline but i just cant make my mind up yet.
 
I recommend phenibut for occasional use, it really produces a wonderful feeling, however it's hard to dose right, a little too little and you don't really get much from it and a little too much and you have a drunk/hangover-like state where your legs hurt and you're really, really tired.

I really like piracetam, though I must say all racetams are very subtle, you have to work with it to notice its benefits.

My favorite nootropic is hydergine (ergoloid mesylates), which, like LSD, was created by Hofmann, who said he took it every day (and he lived to be 102 and was very cognizant til the end). Hydergine is hard to get, you have to order it from overseas as far as I know and it's expensive. But most strongly beneficial, for me.
 
How effective is Hydergine?

Also I have been trying to find some up-to-date information on piracetam.

Is it worth taking? I don't smoke bud anymore, it has been a month and a half since I stopped. The first two weeks off were bliss but ever since then I have been absolutely struggling to have focus on anything. Memory has been on the decline a noticeable bit.

Considering I've been eating the best I ever have for the past 6 months and exercising constantly, would it be beneficial to start taking piracetam or another kind of nootropic?
 
I find piracetam to be quite nice, especially for memory issues. Also, hydergine is the most effective nootropic I have taken, it provides mental clarity, memory, and helps with anxiety and depression too. I miss it but it's expensive.
 
I wish everyone took hydergine. It made me remember memories from my past that i'd forgotten and seemed to allow my mind to make associations to things further back in my memories, and faster too.

My friends in my dorm noticed the difference in me. I'm such a stoner that they made comments like, 'you've been walking around with your eyes open this week what changed?' haha
 
Thanks for the comments guys! Once you both stopped taking piracetam/hydergine were there any withdrawal symptoms/negative effects?

If one was to take either of these, what would an appropriate dose be? (Accounting for weight, age, etc).

Just want to make sure if I go down this road I want to label any and all downsides if any. :) really appreciate any insight anyone could offer.


EDIT: Also just wondering if anyone could provide any information on Noopept?

Specifically speaking, I'm on the hunt for a nootropic that can help repair my memory and if possible, help me focus a whole lot better preferably without any "high". But I'd honestly appreciate any insight that anyone has to offer. :)
 
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Nothing like withdrawal whatsoever. When I stopped taking them I still felt the effects for quite a while, they gradually reduced but I can't pinpoint when exactly. I took them for years, the hydergine probably for more like a year and half and the piracetam for probably 4 years (on and off, I found it works best when you take breaks as after a while it seemed counterproductive, then a month later I'd start again and get the benefits again).

I recommend piracetam and hydergine. Honestly hydergine is the best nootropic I have ever taken but it's harder to get and expensive. A friend of mine, an ex-Bluelighter, once contacted an US chemical supply company and told them he needed a gram of pure hydergine for research, and they sent it... he didn't really end up using much and gave it to me. This was much cheaper but I am not sure I would actually do that myself. When I have gotten it for myself, I ordered it in pharmaceutical pills from Europe.
 
Have you tried aniracetam and other racetams Xorkoth? IMO aniracetam is simply a more potent and much improved version of piracetam, I would always opt for aniracetam given the choice.

If one has the money to spend I would personally also take Xorkoth's recommendation of hydergine seriously, it sounds wonderful and you can also sell me on the chemical similarity to certain other substances ;)

I just wrote an elaborate post on Noopept, afterlyfestyle - scroll up a bit - if that is not enough it includes a link to the dedicated noopept thread.

None of these nootropics produce a high, IMO that is kinda the point: to separate and isolate the cognitive enhancing and supporting effects and make them sustainable. Whenever there is a high present with a substance, it becomes very likely that it is not 100% durable but in some way exploiting / depleting. There is no such thing as a free lunch, even with cholinergics it is wise to supplement with a choline source to avoid depletion due to excess conversion to acetylcholine. And even choline itself is not 100% safe to take as it has slight risks of causing damage to the heart, though I really don't think acutely.
That latter risk is something that makes me say: please don't take grams upon grams upon grams of choline sources all day every day, but it doesn't completely turn me away either. IMO you can't avoid all small risks in life, that's simply no way of living.
 
I have tried aniracetam, I still have most of it because I found it to make me feel weird. It gave me tired feeling behind my eyes, I also associate this feeling with getting sick. It's been many years since I tried it, I recently found my small tub of it in the garage, since it doesn't absorb water it hasn't molded or anything, so I could use it. I may give it a try today, what dosage do you usually use?
 
About 750 mg, I think unpleasant feelings behind the eyes may be related to tension headaches, but if it is a tired feeling maybe that's different.

I always find it funny how much it can smell of anise, probably most of all (or only) if there are traces of unreacted anisoyl chloride left. Pretty sure that is why they called it aniracetam, as it doesn't make me feel like a Skywalker at all. I hope in Episode VII there are junkies IVing midichlorians.
 
I don't know but I think that racetams may enhance a lot of effects indifferently, whether they are the desirable effects of stimulants, psychedelia from acid, or side-effects or toxicity from poisonous substances. Dissociatives seem to be one of the exception though because a bizarre dissociative trip basically benefits from disruption of cognitive brain function rather than boosting.
 
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