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[MEGA] Synthetic Cannabinoid Discussion - Take 4

Yeah. Most synthetic cannbinoids are full agonists, as opposed to THC, which is a partial agonist. It means you can get much more high on such synthetic cannabinoids. But you can also get anxiety/paranoia that weed couldn't touch, and withdrawal symptoms on par with popular depressants and stimulants.

The synthetic cannabinoids, or 'noids, are understudied. Most of the ones which have been have been found to be carcinogenic.

Please do not generalize like that without knowledge, or appropriate reference. Most studies on cannabinoids have provided very positive results, in many conditions. carcinogrenecity has not been mentioned in any of the ones I read. PLEASE google cannabinoid research.
 
Anyone got any info on withdrawal from the synthetics? What is it that actually causes the withdrawal? I tried stopping just to see how I would feel, and I felt horrendous after 24 hours, it was just completely intolerable. Felt like I forgot to take a benzodiazepine.

What mechanism of action causes this withdrawal? NMDA receptor over-activation? It would help to know so I can combat it with something else, I am kind of tired of smoking 'noids all day and my pain meds are not working as they should so I need to take a break and reasses my situation really but I can not stack another withdrawal on top of my already on going PAWS from both benzos and opiates because I can not tolerate it at this point.

Anyone got any tips? Dissolving them in oil for easy liquid titration and then oral dosing for a more constant level in the bloodstream while tapering might be an idea I think.
 
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I'll give it to you: I'm about to CT crackabis myself... So we'll see, it's a question of days now. I'll report back in a week ;)

I've got Valium.
 
dark chocolate should help relieve cannabinoid withdrawal symptoms

this stuff can be an aquired taste for some people, but i love it.... and it has the most cocoa out of pretty much any chocolate on the shelf, so will provide maximum benefit:

tumblr_lmuspg47Iy1qirofh.jpg


caution, though: it tastes pretty bitter at first. you have to let it melt in your mouth and suck on it a bit to release the flavor.
 
Anyone got any info on withdrawal from the synthetics? What is it that actually causes the withdrawal? I tried stopping just to see how I would feel, and I felt horrendous after 24 hours, it was just completely intolerable. Felt like I forgot to take a benzodiazepine.

What mechanism of action causes this withdrawal? NMDA receptor over-activation? It would help to know so I can combat it with something else, I am kind of tired of smoking 'noids all day and my pain meds are not working as they should so I need to take a break and reasses my situation really but I can not stack another withdrawal on top of my already on going PAWS from both benzos and opiates because I can not tolerate it at this point.

Anyone got any tips? Dissolving them in oil for easy liquid titration and then oral dosing for a more constant level in the bloodstream while tapering might be an idea I think.

I use nootropics, Chia seeds, Omega 3 oil, along with pumping myself with foods that contain natural cannabinoids (Echinacea angustifolia root powder, cashews, chocolate, flax seed etc....

step down is a good idea, gives the system time to gradually readjust.
 
dark chocolate should help relieve cannabinoid withdrawal symptoms

this stuff can be an aquired taste for some people, but i love it.... and it has the most cocoa out of pretty much any chocolate on the shelf, so will provide maximum benefit:

caution, though: it tastes pretty bitter at first. you have to let it melt in your mouth and suck on it a bit to release the flavor.
the best is organic non-standardized cocao powder.

the standardized stuff has too much Lecithin and other additives to get the full benefit out of it.
 
I bet the anandamide gets transported the same with even 35% cocoa butter. Anyway thanks, I'll try to get this sort of cocoa.
 
I bet the anandamide gets transported the same with even 35% cocoa butter. Anyway thanks, I'll try to get this sort of cocoa.

yeah,

the problem with the standardized cocoa is how the other ingredients metabolize,

the Lecithin for example in large amounts causes headaches and nausea.

You can consume a lot more organic non-standardized cocoa without side effects, enough to take one to cocoa heaven if they desire!
 
Anyone got any info on withdrawal from the synthetics? What is it that actually causes the withdrawal? I tried stopping just to see how I would feel, and I felt horrendous after 24 hours, it was just completely intolerable. Felt like I forgot to take a benzodiazepine.

What mechanism of action causes this withdrawal? NMDA receptor over-activation? It would help to know so I can combat it with something else, I am kind of tired of smoking 'noids all day and my pain meds are not working as they should so I need to take a break and reasses my situation really but I can not stack another withdrawal on top of my already on going PAWS from both benzos and opiates because I can not tolerate it at this point.

Anyone got any tips? Dissolving them in oil for easy liquid titration and then oral dosing for a more constant level in the bloodstream while tapering might be an idea I think.

When I was younger and things were legaler, I used to smoke 3g of JWH (018 and 250) in like 5 days, sharing here and there with a few people.

As long as you have weed at some point later, and you stop looking up Cannabinoid stuff, you will eventually just get over it without withdrawals.
 
I researched a lot of FUB-PB22 today, and I must say that THJ-2201 is tripper and less lethargic than FUB-PB22. (It does not compare to AM-2201; my supplier finally couldn't help me out with that (maybe I was the only person in 2014 getting it?).

I try to overdose on both chemicals on purpose, you know, for harm reduction research. THJ-2201 actually produces "The Fear" more than FUB-PB22; unfortunately, FUB-PB22 has some sort of ceiling effect that THJ-2201 lacks. It does not cause much anxiety, only slightly trippy, and makes my headspace feel weird for about 3 hours total.

Not my favorite, but I will likely still research all of it.

For typical research, FUB-PB22
For harm reduction research, THJ-2201 :)
 
I urge everyone who enjoy this third generation of 'noids to stack up because the fourth that is coming now seems to be a major disappointment. I made this misstake with generation one, didn't buy enough then the second wave arrived (UR-144 etc) which I didn't enjoy that much.

Now the third has had some enjoyable ones, and especially potent ones! 5F-Akb48 and 5F-PB-22 was both very potent and nice cannabinoids in my view, I really regret I did not stack up more.

With those gone it seems like I am going to have to wait a few years again before I find something interesting. I have major tolerance so all these weak 'noids are useless to me. I also don't enjoy them, if the 'noid doesn't couch-lock me it's not worth my time. I just don't understand how they are reasoning when they release much weaker chems to the market after people have used the stronger ones for a long time. Naturally most people are going to be disappointed, which seems to be the general oppinion on the 'net so far about this new wave cannabinoids.

/rant

edit: I have a question too if someone remembers, which OLD cannabinoid was it that lasted approximately 12 hours? Was it CP 55,940 or CP 47,497? Trying to figure out which one I should pick between the two. Suggestions?
 
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So what is the half-life of these synthetic canabinoids like AB-FUBINACA ?
 
So what is the half-life of these synthetic canabinoids like AB-FUBINACA ?

I can't wrap my head around the fubinaca. It constantly has varying effects from different vendors. But it should last abit longer than most cannabinoids. ~1 hour approximately.
 
I can't wrap my head around the fubinaca. It constantly has varying effects from different vendors. But it should last abit longer than most cannabinoids. ~1 hour approximately.
Yes the effect of the drug. That I have experience with but what Im really asking is the half-life for the drug to eliminate from ones body,
I.e for the drug to pass so you do not have it in your urine?

I know it doesn't show up on standard drugscreens here(in my country) but analysis of urine does show the substance and if your on a program say Bupe or Methadone you obviously can't have drugs in you.
 
Just to share a few I've found.

O-1057, O-1812, AM-2232, O-774, AM-2389, HHC, HU-243, Canbisol, Nabilone, 11-OH-THC, 2-AGE, Paxahexyl, THC-C4, AMG-36, AMG-41, AM-1235, AM-906, AM-365, O-2694, O-2372, O-2113, O-2050, VCHSR, TM-38837, PiplSB, PF-514273, MK-9470, LY-320,135, O-2545, PD-128,907, PF-219,061, ABT-670, ABT-742, UK-414,495, OSU-6162, Melanotan II, Oxaflozane, PF-592,379, 4-HTMPIPO, A-41988, AB-001, AB-005, ADBICA, AM-087, AM-411, KM-233, AM-679, AM-694, AM-855, AM-905, AM-919, AM-4030, AM-938, AM-251, AMG-1, AR-231,453, PSN-375,963, PSN-632,408, (C6)-CP-47,497, CCH, O-1871, CP-55,940, CP-47,497, CP-50,556'1, CP-55,244, Otenabant, (C9)-CP-47,497, CBS-0550, AVE-1625, GW-842,166x, HU-308, HU-336, HU-331, HU-320, Ajulemic Acid, JTE-7-31, A-834,735, MDA-19, S-444,823, JTE-907, JWH-015, JWH-019, JWH-030, JWH-047, JWH-048, JWH-051, JWH-057, JWH-081, SLV319, 2-Isopropyl-5-Methyl-1-(2,6-dihydroxy-4-nonphenyl)cyclohex-1-ene, HU-345, JWH-098, JWH-116, JWH-120, JWH-122, JWH-147, JWH-148, JWH-149, JWH-161, JWH-164, JWH-167, JWH-175, JWH-176, JWH-184, JWH-185, JWH-196, JWH-203, JWH-249, JWH-302, JWH-307, JWH-359, JWH-398, JWH-424, L-759,633, L-759,656, GW-405,833, Leelamine, NESS-0327, NESS-040C5, NMP-7, Nonabine, O-1125, O-1238, O-1269, O-806, O0823, Org-27569, Org-28312, LBP-1, Org-28611, Otenabant, Perrottetinene, PF-03550096, RCS-4, RCS-8, Rosonbrant, SDB-001, SDB-006, SER-601, Serinolamide A, THC-O-Phosphate, Tinabinol, VDM-11, Virohamine.
 
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