Stimulants Anyone else have anelgesic effects from meth?

[jordanalice]

Hi!

I'm curious if anyone else has noticed pain killing effects from using meth, and also if anyone has experienced this from legal amphetamines?

I have endometriosis and in 2010 it progressed really quickly and I ended up spending over a year in bed on morphine, which didn't really help. I started using crystal regularly last spring to give me some energy and amazingly found that I was more or less completely pain free for the first time in years. Barely took advil or tylenol all summer. I read a study awhile ago saying that meth has relaxing effects on smooth muscles but I can't seem to find that article any more or any thing else like that. But I've also read that amphetamines have really negative effects on disorders of the endocrine system.

I moved back to my home town and have desperately been searching for meth since I've been here, no luck at all. Does anyone have any recommendations for something or a combination of things that might have a similar positive effect for me? I'm in canada and I believe desoxyn isn't available here. I had a bunch of dexies a couple weeks back and they just made me space out into the computer for days reading about things I wasn't interested in, didn't really give me energy at all beyond the ability to stay awake for days.

My doctor is pretty good, but he's also a strong believer in homeopathic and natural medicine. He generally prescribes me whatever I ask for if it seems like I know what I'm talking about. Even so, I have to be careful because I have a known history of substance abuse issues, and if my motives come across as such he'll be more reluctant. Opiates are not an option for me either.

Thank you!

 

[randysmackage]

Yes. I have noticed that it does help with my tooth aches and headaches. A few people I know have also noted on its pain killing properties.

 

[sekio]

This is well-known in medicine, norepinephrine releasing drugs like amphetamine (to a lesser extent tramadol, orphenadrine, and other drugs like SNRIs) work as analgesics and also potentiate morphine analgesia. It's not a first-line treatment though.

 

[keeponkeepnon]

Finally someone brought this up again. I was prescribed dexadrine and adderall for years all while being sick with lyme disease. The amphetamines basically masked the lyme I never even knew I had chronic pain till I went off them one summer. Suddenly I was in so much pain I could barely walk around without wincing with every step taken. Been free of the stuff for 2 years or so thankfully. Now it's all about downers ahhh at least they are prescribed ha. Oh well do what ya gotta do to get by when you're sick. Does anyone have any journals on the subject matter ? Remember seeing one ages and ages ago but haven't found anything while looking myself. Would love to read more. Be well all and to the op I hope you find something to make you feel better or just plain feel better one way or another.

 

[Non Nobis Solum]

This is well-known in medicine, norepinephrine releasing drugs like amphetamine (to a lesser extent tramadol, orphenadrine, and other drugs like SNRIs) work as analgesics and also potentiate morphine analgesia. It's not a first-line treatment though.

On point... Meth/amphetamine can also be a big ache if you've been up for 48+ hours.

 

[sekio]

Eur J Pharmacol. 1984 Jun 1;101(3-4):267-9.
Amphetamine-induced analgesia does not involve brain opioids.
Drago F, Caccamo G, Continella G, Scapagnini U.

The intrinsic analgesic properties of amphetamine were studied in rats. Subcutaneous injection of amphetamine exerted an additive effect on morphine-induced analgesia in the hot-plate test. Amphetamine itself showed intrinsic analgesic activity in a dose-dependent manner. Administration of naloxone failed to affect the analgesia induced by amphetamine. However, injection of haloperidol totally suppressed the amphetamine-induced change in pain response latency. Both naloxone and haloperidol failed to affect the pain threshold when injected alone, but inhibited morphine-induced analgesia. It is concluded that amphetamine possesses intrinsic analgesic properties which involve catecholamine but not opioid transmission in the brain.

Pain. 1988 Jun;33(3):363-8.
Potentiation of morphine analgesia by D-amphetamine is mediated by norepinephrine and not dopamine.
Izenwasser S, Kornetsky C.

Morphine will raise the threshold for escape from aversive electrical stimulation delivered to the mesencephalic reticular formation and this effect is potentiated by D-amphetamine. In order to study the roles which dopamine and norepinephrine play in modulating opiate analgesia, the effects of amfonelic acid, an indirect dopamine agonist, and nisoxetine, a selective norepinephrine reuptake blocker, were determined alone and in combination with morphine using this supraspinal model of analgesia. Amfonelic acid alone produced hyperalgesia and completely antagonized the analgesic effect of morphine. Nisoxetine had no effect by itself, however, it potentiated the analgesic effect of morphine when the two drugs were administered concomitantly. These findings suggest that norepinephrine and not dopamine plays a predominant role in the potentiation of opiate analgesia by D-amphetamine.

Clin Exp Obstet Gynecol. 2013;40(2):227-8.
Sympathomimetic amines effectively control pain for interstitial cystitis that had not responded to other therapies.
Check JH, Cohen G, Cohen R, Dipietro J, Steinberg B.

PURPOSE:

To further investigate the efficacy of treatment of interstitial cystitis that had been refractory to standard treatment with sympathomimetic amines.
METHODS:

Dextroamphetamine sulfate sustained release capsules up to 30 mg per day were prescribed in women with refractory painful bladder syndrome/interstitial cystitis in six new cases. The patients were carefully evaluated for relief of symptoms.
RESULTS:

All six women found marked relief in their painful bladder syndrome in a rather short length of time. The benefit persisted as long as the therapy was maintained. Temporary cessation resulted in prompt return of symptoms, but resumption of sympathomimetic amines again allowed good relief of bladder pain and related symptoms.
CONCLUSIONS:

Because of very few side-effects and no drug dependence in the dosage used, sympathomimetic amines should be considered for first-line therapy.

http://www.ncbi.nlm.nih.gov/pubmed/17030082
http://www.ncbi.nlm.nih.gov/pubmed/23500194

There's more studies in addition to this. I imagine the public image of amphetamines makes it kind of hard to believe they are OK painkillers.

 

[Lightning-Nl]

It's a documented phenomena.

It's believed that it has something to do with reuptake inhibition of Norepinephrine. Increased Dopaminergic activity also contributes. Amphetamine does raise levels of Endorphins (apparently) so that likely contributes as well. Amphetamine also potentiates (adds to) the analgesic effects of Morphine.

http://www.ncbi.nlm.nih.gov/pubmed/3262211

 

[sekio]

Increased Dopaminergic activity also contributes. Amphetamine does raise levels of Endorphins (apparently) so that likely contributes as well.

Neither of these seem to contribute to its painkiller effects: selective dopamine releasers do not cause analgesia, and amphetamine analgesia is not blocked by naloxone. The finger is pretty firmly pointed at NE.

Also, noradrenergic activity (via a2A/a2C receptors) is probably responsible for some of the non-opioid painkilling properties of drugs like mitragynine. NRI inhibition is part of tramadol's action and is also responsible for part of DXM's potentiation of opioids as well.

Maybe someone needs to try ethylcathinone as a painkiller adjuvant?

 

[Lightning-Nl]

Neither of these seem to contribute to its painkiller effects: selective dopamine releasers do not cause analgesia, and amphetamine analgesia is not blocked by naloxone. The finger is pretty firmly pointed at NE.

Also, noradrenergic activity (via a2A/a2C receptors) is probably responsible for some of the non-opioid painkilling properties of drugs like mitragynine. NRI inhibition is part of tramadol's action and is also responsible for part of DXM's potentiation of opioids as well.

Maybe someone needs to try ethylcathinone as a painkiller adjuvant?

Opioid activity may not contribute, however, the study I listed said that Dopamine modification did seem to have something to do with it.

 

[jordanalice]

Seiko, Thank you for posting these studies. I'm extremely cloudy from fatigue and I've been having a hard time doing research and finding any info. I know a couple women with IC that could really benefit from this. Thank you.

 

[jordanalice]

Finally someone brought this up again. I was prescribed dexadrine and adderall for years all while being sick with lyme disease. The amphetamines basically masked the lyme I never even knew I had chronic pain till I went off them one summer. Suddenly I was in so much pain I could barely walk around without wincing with every step taken. Been free of the stuff for 2 years or so thankfully. Now it's all about downers ahhh at least they are prescribed ha. Oh well do what ya gotta do to get by when you're sick. Does anyone have any journals on the subject matter ? Remember seeing one ages and ages ago but haven't found anything while looking myself. Would love to read more. Be well all and to the op I hope you find something to make you feel better or just plain feel better one way or another.

My friends mother had lymes and her doctor actually tried to prescribe her Dexedrine, she turned it down and said he was crazy.

I've been away from the internet for over a year, and have never looked into amphetamines as a pain treatment option so maybe I'm just out of the loop. But I'm confused as to why it's not something more common if it is effective. Really, chronic pain and fatigue can come hand and hand, and I find stimulants to be way less addictive than opiates. I just spent almost a year using meth daily and after being sober two months I feel okay addiction wise (could be in denial). I took percocet for over a year and it destroyed me for the following three years, and the year I spent on morphine was hell. Coming off it left me depressed, sick and completely obliterated my self esteem. I know this isn't the same for everyone, but doctors should be more willing to work with their patients and their specific needs.

keeponkeepnon- thank you for the well wishes. I'd take an addiction over pain any day.

 

[Lightning-Nl]

The only problem is Amphetamines tend to give people headaches at relevant dosages (in my experience anyways). Normally, you could take some caffeine (drink a bit of coffee or something) and it would go away - but even small amounts of caffeine with high amounts of psychostimulants... Is a recipe for disaster.

Personally, I think it depends on the type of pain. I experience horribly painful RLS and Adderall seems to get rid of 80% of the associated pain. Whereas - if I'm having horrible chest pain, stomach pain, or head pain; I've always found Benzo's to be the most effective painkiller (aside from opiates of course)

 

[opiatekrzy]

OF COURSE! i got injured and have to do physical therapy, but what i do is take my ADDERALL, it kills 60% of the pain, so yeh i think amps have analgesaic/ painkiller effects AS IT RELEASES adrenaline

 

[jordanalice]

I've always had an issue with headaches, but amphetamines don't seem to make it any worse. I also drink more water when I use as well, which helps with headaches. Coffee helps as well, but frequently makes me really tired.

SwampFox, when you say even small amounts of caffeine with high amounts of psychostimulants is a recipe for disaster, are you talking about possible effects on the cardiac system? My boyfriend(?) sometimes takes a lot of energy pills with a ton of caffeine in them when he's using, I've been trying to explain to him that it's a bad idea and he wont listen. Someone elses words might help convince him.

Sorry to hear about the RLS. I might be wrong on this but neurological pain is hard to treat, glad there's something that can help you. I've been experiencing what seems like symptoms of early stage MS the last couple years (not jumping to conclusions, I know it's way to early to tell) and found that meth usually helped with body pains and sensations, but also made them worse during certain stages of my cycle. I think another part of it helping relieve my endo symptoms was considerably less eating and a positive change in what I did eat (my uterus is stuck to my colon). Maybe being slightly anemic can sometimes be beneficial for a broken uterus as well.

opiatekrzy, do you find that you over extend yourself during physical therapy if you're using adderall? I'd be worried that if I took something that boosted my energy and helped with pain while I was recovering from something I'd end up hurting myself.

 

[DoctorSativa]

YES, I know of an excellent pain reliever not involving opioids. Paracitamol, may or may not be available in the US, is used in India to treat feavers and pain. Taken with Ibprofin the effects (and even a very small high) are similar to a weak perkoset, legally!

A legal opioid tea: Kava Kava (no source provided here I believe, plus it's legal). It's an opiate and will have surprisingly strong effects if taken in very large doses. Please don't get addicted to it, it's slightly expensive and that would suck for you.

About meth decreasing pain, It depends on the type of pain and that the batch is fairly high quality (which lots aren't; a common source for most people is shit and no I will not tell you what source this is), but in almost all cases: YES. I IV'd 50mg's of incredibly potent meth in San Francisco, felt weightless and swam in the freezing ocean with my girlfriend (who was also high) not even feeling the cold. I have acute scholeosis and it is not bad when the peak of the meth high is present and I can't even feel it until I'm well into the comedown... at which point the pain is worse!

Meth makes pain worse when you come down. Staying up for days if you have back issues gives your back no chance to rest, on the 3rd day of no re-dose my back pain went from OTC-med manegable, to painless, to deabilitating. Go easy on the meth and if you want real pain relief take some Aleve and if you really need to Percoset. Don't take anything stronger and switch between Percs, Aleve and Ibprofin every month or so to avoid addiction... EDIT: Scratch the perks, go to a different doctor who doesn't know your history and get them from him. If you can't get them switch from Aleve and Ibprofin and paracitamol.


I have never experienced pain relief from legal amphetamines, you could maybe try something with dextroamph in it although when I would shoot amphetamine sulphate (similar to many legal amphetamines) sometimes I would get a terrible head pounding on large doses followed by pain relief for the day. But you MUST sleep as you naturally would every night, or else they stims will make the *muscle* pain worse.

And I certainly don't need to mention the acute mental and physical pain caused by opiate withdrawal!!!

 

[LucidShroomDmtier]

shot meth once and i had stuid idea to shave my beard came by, my arms was moving quikly and pressing hard so i actually made it to cut myself badly on face in 2 sec, i didnt felt any pain or shock while i was getting all bloody . i just quikly put med kit on face and finished my shaving . i also though then thts why they gave it to kamikazis and soldiers . i doubt i would feel anything if o even got shot

 

[jordanalice]

YES, I know of an excellent pain reliever not involving opioids. Paracitamol, may or may not be available in the US, is used in India to treat feavers and pain. Taken with Ibprofin the effects (and even a very small high) are similar to a weak perkoset, legally!

A legal opioid tea: Kava Kava (no source provided here I believe, plus it's legal). It's an opiate and will have surprisingly strong effects if taken in very large doses. Please don't get addicted to it, it's slightly expensive and that would suck for you.

About meth decreasing pain, It depends on the type of pain and that the batch is fairly high quality (which lots aren't; a common source for most people is shit and no I will not tell you what source this is), but in almost all cases: YES. I IV'd 50mg's of incredibly potent meth in San Francisco, felt weightless and swam in the freezing ocean with my girlfriend (who was also high) not even feeling the cold. I have acute scholeosis and it is not bad when the peak of the meth high is present and I can't even feel it until I'm well into the comedown... at which point the pain is worse!

Meth makes pain worse when you come down. Staying up for days if you have back issues gives your back no chance to rest, on the 3rd day of no re-dose my back pain went from OTC-med manegable, to painless, to deabilitating. Go easy on the meth and if you want real pain relief take some Aleve and if you really need to Percoset. Don't take anything stronger and switch between Percs, Aleve and Ibprofin every month or so to avoid addiction... EDIT: Scratch the perks, go to a different doctor who doesn't know your history and get them from him. If you can't get them switch from Aleve and Ibprofin and paracitamol.


I have never experienced pain relief from legal amphetamines, you could maybe try something with dextroamph in it although when I would shoot amphetamine sulphate (similar to many legal amphetamines) sometimes I would get a terrible head pounding on large doses followed by pain relief for the day. But you MUST sleep as you naturally would every night, or else they stims will make the *muscle* pain worse.

And I certainly don't need to mention the acute mental and physical pain caused by opiate withdrawal!!!

paracetamol is sold as acetaminophen in Canada. I agree that its a good pain killer, but not for long term/regular use. It's really hard on your liver and and chronic users apparently have a higher chase of developing blood cancer. Ibuprofen (or any other non-steroidal anti-inflammatory) isn't good to take regularly either, risk of heart and kidney problems. Either way I've used so much of these they no longer work for me. Surprised to hear that you get high from using these, although I have friends that say advil helps them sleep.

I've heard of Kava Kava before, I have no idea what it is or whether or not it's legal here. I'll look into it, thank you for the recommendation. I had a good connection for quality meth and I'll hold out for another one, low quality stuff does nothing but bad for me. I didn't find an increase in pain with coming down though, at least nothing extreme.

 

[jordanalice]

Thank you for your responses doctorsativa and lucidshroomdmtier. I'll make sure I steer clear of cold water and shaving my bear when I'm high.

 

[sekio]

Kava is not an opioid, it activates the GABA and cannabinoid receptors as well as blocking MAO.

 

[jordanalice]

Sekio, my doctor wants to give me Ritalin instead. I'm guessing it's not going to have the same pain killing effect that Dexedrine might?