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Opioids Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope

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Cool. I've come across several (non-fatal) ODs from loperamide. It seems that once there is such a large amount in the blood, the dose/response curve gets a LOT steeper. I know of 3 people waking up in hospital. One even developed compartment syndrome and it was touch and go for several days. Others have similarly collapsed to awake in ER. Having never seen it, I don't know if it displays the usual signs for opioid OD but, sadly, in no case did the victim TELL the staff what they had done. Since it's legal, I never worked out quite why. Even in an addled state, I would be thinking 'there is an increasing number of (primarily US due to low price of stuff) opioid-dependant people doing this so anything that could help others...

But then I don't know what a US doctor would make of it. Maybe your branded suicidal & sectioned - I don't know. Retrospect is always 20/20.
 
Sigh... :(
You can say that again, brother.
I miss the days of 10mg percs fuckin' me up, making me spew. The good ol' days are over.
 
man ive been on lope while WDing from subs, and i feel perfectly normal. its a miracle

20mg twice a day 4 days in and i feel fine..my last does of subs was like .25mg though
 
That is a very low dose of subs. I jumped off at 1 or 2 mg's after a rapid taper. But have also jumped at 4 and 8.

I hope you plan on jumping off the lope. Lopermide is actually very potent, but it's oral BA is very low. It's BA is 0.3% which is extremely low. If there was a way to increase it's BA to a higher level it would be interesting to see what would happen.

The dose of lope your taking a day is probably almost as strong as the sub dose you jumped at.
 
ya gona take the lope until i get my kratom order on friday ,then take kratom then be done with it..

i went from IVing 4mgs a day then to 1mg sniffed within 1 month then .25 two days after
 
My ass has still been on 24 mg daily for god knows how long. If anyone is wondering how long someone can 'safely' be on this high of a dose, in my case, years. I still have messed with 'real' opiates on occasion in those years (on days that I have I usually abstain from my daily lope), although I usually end up saying to myself 'why did I spend all that money for something that just *barely* got me high?'

I suspect that my lope habit has ruined my recreational opiate tolerance.

Why don't I taper off lope after years? Good question with a few reasons. Being able to get 400x 2mg pills for under $10 is one reason. Also, I am a case of post-operative Ulcerative Colitis, and without it I am much more likely to have loose bowel movements. Lope slows me down to provide better digestion and better water absorption through my small intestine.
 
I still think all of this is kinda crazy...ppl taking boxes of the stuff with stomach acid meds, gf juice, black pepper lol. Its pretty easy to find codeine online...id go with that tbh. Seems like loperamide would eventually cause you to poop out a football lmao...it def helps when youre in bad wd but thats it. Otc methadone as someone once called it is a bit of a stretch.
 
I am on year three of very high dose Loperamide. I won't name the mg amount as I feel if some others take the dose I do, they will OD and suffer respiratory failure. Don't forget this is a narcotic, and just as dangerous once you overwhelm the BBB and yield CNS effects.. your O2 saturation lowers, just like any other opioid.

It holds me not only physically, but psychologically too. I get so impaired at times that I don't even consider driving a car, to give you an idea of how effective this is for me.

Recently, UPS was having problems delivering parcels. I was out of lope and was in withdrawal but had 35mg of Oxycodone left over.

Amazingly, I was still able to feel it, despite taking a 3-digit milligram figure of Loperamide for years. Of course, it yielded only a puny 8 hours of relief compared to the 36-48 hours I get from each gulp of Loperamide.

Why do I do this? Because unlike Methadone Maintenance, and better yet Buprenorphine maintenance, I don't have to have the scarlett letter of "addict" Potential DSP/Drug Seeking Patient in my permanent medical file. I get to keep my addiction, yes I long ago admitted to myself that I am an addict, a secret from loved ones. I can relatively function. I know there are very real risks regarding possible metabolites and parkinson's disease, and a recently released study about loperamide ultradosing causing issues with cardiovascular system (QtP latency or some such... a person went into cardiac arrest.. I posted it a few pages back..)

Even with "ObamaCare"/Reformed Medicaid now covering more substance dependency recovery programs, I know I'd be piss poor broke going on MMT or Bupre maintenance, and I'd have to go to some office daily unless I got lucky and got monthly Buprenorphine outpatient.

...And I doubt ANY clinic would put me on either for a dependency and addiction to Loperamide - and if they did Medicaid would not cover it as a treatment.

So I will continue to self-medicate with Loperamide, responsibly. I know which dose causes my O2 sat to drop lower than is safe, and I never cross it. I take measures to prevent chronic GI issues like bowel obstruction, perforated intestine, etc.

I am grateful that I still have money leftover each month and the only time I am in withdrawal is the rare case where my UPS next day air reup is delayed a day or two -- and if its really bad I can drive to even a gas station to get a 48 count bottle to get relief.

I don't have to steal, beg, borrow, or make my life revolve around finding a fix... so even with all the problems that comes with using this in-the-closet opioid that most pharmacists probably aren't even aware is a narcotic (look for the word opioid and narcotic on the packaging, you won't find it) I am grateful that this exists and that it DOES cross the BBB in high doses.

My fear is that some senator's son will overdose from it, probably while on Skype or something resulting in a youtube video, and that will ruin everything.

So I am also thankful for the ignorant stigma attached with this too "lulz getting high off poop pills" [nevermind the fact that there are no other drugs that treat loose stool except narcotics.... name one... all "poop pills" are opioids, and LAUDANUM -- now called DEODERIZED OPIUM TINCTURE -- is given to NEWBORNS who have diarrhea in the US.

So while I roll my eyes at the ignorant responses about "getting high off poop medicine" I pause and realize that such uninformed stigma will likely prevent loperamide from becoming so widespread that some moron teenager will die from it and cause it to be moved back to Schedule V.

This drug provides a cheap reliable, but yes risky way to self-medicate into a maintenance therapy - without sacrificing when they get cancer when they are 80 access to fentanyl. Anyone with DSP or addict in their medicine file will be lucky to get 10 Tylenol 3 tablets per prescription for Stage 3 cancer.

So, my advice for what it's worth.. if you don't have an opioid dependency and/or habit... don't use Lope for anything but its meant for - loose stool. And don't advise anyone else to use it for euphoria. If you're a chronic pain patient who is cruelly undermedicated by your doctor, be careful if you are using this as a stop-gap analgesic.. in my experience loperamide is a horrible analgesic because it has a VERY slow onset. Withdrawal from loperamide lasts WEEKS rather than DAYS for short acting opioids like oxycodone.

And keep teens away from this at all costs. lol.

And you MUST use a stool softener - Miralax or generic or if you can get your hands on it Methylnaltrexone [NOT naltrexone!] to prevent DEADLY complications from chronic constipation. Take a normal dose as advised by the label [OTC not Rx dose] of Miralax AFTER ingesting Loperamide but BEFORE a large meal to avoid painful BMs.
 
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Already, I vote for the above Timland post to be one of the top ten 2014 harm reduction posts.

I was looking for the top posts of 13 but couldn't find the thread.

Yet, maybe.
 
I have heard of ppl feeling high on loperamide...I've only used it to help w opiate w/d. And more than a few times...that being said...about a yr. ago,I was taking Lyrica for opiate w/d, and it stopped working. ...on day three of sufferering from Lyrica being ineffetive i.e., severe burning, painful stomach I took forty eight two mg. loperamide...Withing fifteen mins, not only was I "back to life", I felt high from it.

That only happened that one time...never before or never since. I use it to help w w/d. I go through three days of feeling bad on loperamide...no sleeping, eating, or drinking for those three days. After the three helacious long days of feeling horrible, I get stable on loperamde...tht's all. I am more than happy to just be stable. I still suffere w/d the first three days. And that's it. It was a one time only thing that I Felt something on it.
 
Ok so I've been going through wds from a 2 month 8mg a day suboxone habit. Today is day 6 without any subs. I took 26 mg of loperamide about an hour and a half ago. Orally no gfj or tagament. I feel a slight opiate buzz comparable to tramadol. I'm not taking this to get off only to get through the wds. I feel much much better. I have enemas on hand justtin case.
 
So, I've been out of a 25 gram day kratom habit for a few days and loperamide did in fact help with some of the w/d symptoms. Here's my question, I took approximately 45mg of loperamide over 2 days and tomorrow I should get my kratom, how bad will it affect tolerance? Would 2 days really make that much of a difference?
 
Loperamide discussion

I was curious if this drug was similar to oxycodone? I wanted to buy it because i heard it somewhat relaxes you. Apparently 100mg or more gets you high enough to feel the effects. This true?
 
Loperamide is a peripherally active opioid and has practically no effect on the CNS in normal circumstances. I wouldnt advise this you could get extremely constipated. I believe loperamide is more closesly related to methadone - but no action on CNS opioid receptors. Dont expect this to get you high.
 
There are already several loperamide threads here. Use the search engine.


You're better off getting high off OTC 8mg codeine tabs (they sell em in Canada/AU etc) than 100mg of lope. It'll stop your bowels for a week or more and only with certain people does enough loperamide cross the BBB so that if they took 50x2mg pills they "might" feel a buzz, if they had no tolerance.
 
It works for alleviating withdrawal in high doses, but that's pretty much it. If you take it to get buzzed, you will be disappointed.
 
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