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The Big and Bangin' Pseudo-Advanced Drug Chemistry, Pharmacology and More Thread, V.2

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I have 3 years of organic chem, 2 years of biochem, and 4 years of university level Biology under my belt. I think I should be fine, if the concepts are explains thoroughly; without divergence from the topic at hand.
 
entheo said:
I have 3 years of organic chem, 2 years of biochem, and 4 years of university level Biology under my belt. I think I should be fine, if the concepts are explains thoroughly; without divergence from the topic at hand.
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With that kind of experience you can pick up a textbook at any level. Considering pharmacology is basically just a practical application of all of those disciplines I definitely wouldn't describe you as "a novice in the field".

If you want something very thorough you can't go wrong with any recent edition of Goodman and Gilman's The Pharmacological Basis of Therapeutics, especially if you're interested in therapeutic aspects.
 
Thank you sir, I appreciate it. I have the knowledge of most aspects of the subject, but the nuances of putting them together and understanding the dynamics of their mechanisms are a bit harder to teach yourself.
Ive never take a pharmacology course, so I wasnt sure what I would be gettin myself into.
 
heart rate and adhd medications

The averige increase landed on 5 bpm after a national investigation how ever in sweden methylfenedrate is the most common drug (witch is strange couse we started to treet hyperactivety and som autistic condition with dexadrin 1936 and did so until ritalin (used as weightloss treatment since the 1955) and some other brands grabed the market after a 5 year ban on amfetaminbased treatment in the eyrly ninties. Any way it is fairly known that amfetaminsulfates/salt har less impact on cardio system then methylfenydrates. There are several options on drugs so wy not try out them untill you found the one that effect your hart the least? Its how it s usely done here anyway. If that drug is insufficient in other way then you can have another to use temperarely when you need it. Mostly the increase is not as high as it feels. And there is usely a way to get aourond this if you and your doctor are willing to experiement, som times a crossuse of different amfetaminesulfades and methylfenidades is the solution or it will simply go avay after a regural use, somtimes irregular use is worse in regard to the stressfactor. This issue is however very induvidual and will need a induvidual solution. There is hoewer no indications that adhd treatsment elivates the risk of serios hartfailuer. Hart condisions ar much more complex and is not determent by pulse and pressure alone. The reports of serius reaktions with the adhd drugs is with interraktions with ssri. But ofcurse its all up to you if you feel you want to have the treatments.






Dysphoric said:
How much exactly does your heart rate increase on Meth/Amps?

1.) Lets say a fairly healthy individual took 40mgs of Adderall, how much would their heart rate go up?
2.) And now I want to know what the difference would be if instead they would take Desoxyn at around 20-30mgs, how much of increase?

I would assume Adderall (d-l Amphetamine) is slightly more Cardio-toxic, correct?

I'm curious because that is one thing that gives me anxiety when it comes to drugs, is fast BPM (tachycardia) I have a prescription for Desoxyn, but I've hardly touched it and now that I've started college I want to start taking here and there, around 20-30 mgs. I can handle an increase in BPM, I just don't like too fast, obviously.

Also, I've talked to most of my friends that I've let try Desoxyn before and they said it hardly raised their BPM (vs Adderall), so would Desoxyn hardly touch my BPM at around 20-30mgs?

Also, I'm referring to Oral dosing.
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I assume it's complex, but determines wheher or not a compound in the solid pase is soluble in its liduid phase? Ice doesn't disolve in water, are there substances that for autosolutes? If so, why?
 
technically ice *does* dissolve in water, it just takes a bit =p

depending on the temperature of the external environment, of course. if the external environment is cold enough then the water will also turn into ice.
 
depends how you look at it -- drop some ice cubes into room temperature water and eventually... does the ice melt, or does it dissolve? to me the difference seems to mostly be a matter of semantics.
 
Ice in water can be an equilibrium state where ice forms/"precipitates" and redissolves/"melts"... see also: a Slurpee machine.
 
^ it is definitely a little ambiguous under current definitions

In chemistry, a solution is a homogeneous mixture composed of only one phase. In such a mixture, a solute is a substance dissolved in another substance, known as a solvent. The solvent does the dissolving. The solution more or less takes on the characteristics of the solvent including its phase, and the solvent is commonly the major fraction of the mixture. The concentration of a solute in a solution is a measure of how much of that solute is dissolved in the solvent.

Characteristics

- A solution is a homogeneous mixture
- The particles of solute in solution cannot be seen by naked eye.
- The solution does not allow beam of light to scatter.
- A solution is stable.
- The solute from the solution cannot be separated by filtration (or mechanically).

....

solution --

a : an act or the process by which a solid, liquid, or gaseous substance is homogeneously mixed with a liquid or sometimes a gas or solid
b : a homogeneous mixture formed by this process; especially : a single-phase liquid system
c : the condition of being dissolved

....

would it make a difference if the ice was entirely made of heavy water (D2O) and the liquid entirely of "regular" water?

....

“There are no differences but differences of degree between different degrees of difference and no difference.” -- William James

perhaps the place where i took this discussion would be better suited for the Philosophy forum =p
 
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Ice in water can be an equilibrium state where ice forms/"precipitates" and redissolves/"melts"... see also: a Slurpee machine.
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I find this video of tertbutylalcohol's triple point fascinating to watch.


Have theories seeking to explain the subjective variability of open eye visual intensity experienced between non-tolerant equally dosed psychedelic sessions been forwarded? If not, what are the key factors thought to modulate this variability within the brain? Presumably open eye visuals manifest perceptually due to the presence of psychedelic compounds within the visual cortex and connected regions altering normal signalling patterns (typically through net decreases in activity if my memory serves), but what pharmacodynamic factors dictate transference of compounds within these regions and what are the most promising practical measures that might be taken to modulate them?
 
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Thanatos said:
Are there any books specifically dedicated to pharmakonetics and pharmacology that were written/compiled for the education of a novice in the field. I of course can always go look through my organic chem text books from college but I'd like to have some literature that focuses directly on the subject in question instead.
If you guys could compile a list of books I could buy instead of looking into online databases I would greatly appreciate it.
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this might really help if you're looking for psychedelic pharmacology

Dr. Nichols is a good teacher. I feel as though I absorbed up until some of the SAR stuff quite nicely. I only have a college course called "brain matters" under my belt so maybe you'd get more out of it than me :)

edit: actually theres a lot of unpublished data he uses in various parts of the video so even some of you really well versed in psychedelic pharmacology could learn a thing or two from that video series. MAPS is truly a wonderful thing.
 
SONN said:
this might really help if you're looking for psychedelic pharmacology

Dr. Nichols is a good teacher. I feel as though I absorbed up until some of the SAR stuff quite nicely. I only have a college course called "brain matters" under my belt so maybe you'd get more out of it than me :)

edit: actually theres a lot of unpublished data he uses in various parts of the video so even some of you really well versed in psychedelic pharmacology could learn a thing or two from that video series. MAPS is truly a wonderful thing.
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Thank you good sir.
 
So this is more of an organic chemistry question but, is there a fermenting process that could produce tert-amyl alcohol rather than ethyl alcohol? I know that tert-amyl-alcohol a byproduct of large brewing operations, but could there be a practical way to brew a beer with negligible amounts of alcohol but a substantial amount of tert-amyl-alcohol? I suppose someone with extensive knowledge of the fermentation process could at least give me a point of reference.
 
no. the metabolism of yeast in conditions with low oxygen concentration goes from glucose to pyruvate to acetaldehyde to ethanol. you could certainly produce t-amyl alcohol with GMO yeast (probably even normal yeast, but i don't have the relevant textbook here), but you'd also have to feed it different chemicals.
 
Re: apomorphine-it is unlikely to lead to anything pleasant, save maybe in microdoses. It is a very potent emetic.
 
Do we know of any selective VMAT2 inhibitors? To the extent that we do not, what aspects of SAR (of families of compounds that interact with monoamine transporters) would cause their rarity? Is the structure of VMAT2 similar to these transporters?

ebola
 
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