Generally I agree pmoseman (Ismene usually does not have any facts) with your post but I must stipulate that I said RESPONSIBLE use of magic mushrooms. DMT or analogues do exist in some animals and plants in minute quantities, as you have pointed out. Paracetamol is fine as is NSAID's if taken RESPONSIBLY. Almost any substance is toxic in high enough doses. 5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a brominated indole alkaloid found in certain marine invertebrates. Other examples include bufotenin (frog species) and 5-MeO-DMT, both of which, like DMT, are psychoactive and found in plants and animals. Some light reading: Synthetic Studies of Psilocin Analogs Having Either a Formyl Group or Bromine Atom at the 5- or 7-Position. Fumio Yamada, Mayumi Tamura, Atsuko Hasegawa and Masanori Somei, 2002, Faculty of Pharmaceutical Sciences, Kanazawa University CHEMICAL & PHARMACEUTICAL BULLETIN (Impact Factor: 1.56) 50(1):92-9. DMT occurs in trace amounts, as you said in mammals, including humans, where it putatively functions as a trace amine neurotransmitter/neuromodulator. So I think more than 2 animal species have trace amounts of DMT lol. In this case your facts are a little off although I thank you for bringing the paracetamol dose to my attention.
Lethal dose of paracetamol is incorrect, probably double that for lethal dose. It also takes a while for paracetamol to work it's magic so if you OD get to A+E or ED within 4 hours for the best possible outcome, medically speaking. It will not be a good idea to dose 100 mg per kg as it will cause damage to the liver and unless activated charcoal is given 4 hours post ingestion or IV Parvolex 8 hours post ingestion it can cause permanent hepatic injury I think I got the mg per kg well off for a lethal dose but it was purely going from memory and it means all in one dose so 8 grams = 16 tablet, 12 grams = one box of 24 tablets etc. Run enough infusions through paracetamol OD's but yet to have to attend a magic mushroom OD in A+E. 100 mg per kg is the hepatotoxic dose ie weigh 80 kg's ate 8 grams = fucked up liver, probably not lethal though so I take that back, I meant it really is not a good idea as you will do nasty damage to your liver. Paracetamol is primarily active via hepatic metabolism into active metabolites such as AM 404... interesting. Lots of personality disorders OD on paracetamol as it's available in the supermarket and most people think it's completely benign. Leave it too long, take 2 boxes not 1 before seeking medical attention and you could end up with hepatic failure.
Anyway it's interesting 1 in 1000 for paracetamol. According to your source it is 1 in 10,000 to 100,000 for any form of hepatotoxicity. I've sure as shit treated quite a fucking few paracetamol OD's and yet to see a single magic mushroom OD. I know of people who have had seizures from eating 1/2 an ounce of magic mushrooms and gone psychotic but no real medical OD's. I guess as it's illegal and no real studies have been done and that consuming 1/2 an ounce of magic mushrooms is an extreme case of youthful naivety we may never know. BTW I was not attacking you in any fashion maybe get off the soap box now and again although I do thank you for pointing out to me the dosage of paracetamol needed for hepatic failure was well off. DMT and other analogues ARE found in many living things both plants and animals in either trace amounts or in the case of certain plants and sea sponges in far greater quantities. Another key point is almost every living thing that word again almost. As DMT is a naturally occurring neurotransmitter the trace quantities are all that is required for it's purpose. Taking high doses of DMT is akin to high doses of an SSRI, NDRI, SSRA etc. Not real good in terms of health but unlikely to cause OD/toxicity if used RESPONSIBLY. Any substance can be unhealthy if used to excess, even food.
Ok I'm getting down from my pulpit as the pseudo intellectual and I hope you have a great day/night and the rest of your week and don't take things to heart. I was not supporting any perceived attack on you personally just trying to encourage Ismene to make factual statements rather than biased personal opinion and conjecture. In this case Ismene actually may be more correct than your own poorly researched data. Magic Mushroom related OD's are not a common site in an emergency department, paracetamol OD's are. Occasionally a mushroom poisoning happens to be bought in but they usually mistake toxic mushroom for edible ones, or at least that is the story they give. Researched data does help and in future before making statements I'l check my facts against a few published scientific journal publications. I ENCOURAGE EVERYONE TO DO THIS. WTF is fact monster BTW? Is it an actual peer reviewed scientific journal of some kind? I see no indication of the numerical values stated in your post re: DMT in animals and plants??? The article in the New England Journal of Medicine Victor J. Navarro, M.D., and John R. Senior, M.D. 2006 Drug-Related Hepatotoxicity N Engl J Med,354:731-9 IS a peer reviewed published medical journal however which is really great to see.
