2CI/MXE Tolerance experiment -3 days in a row

[thizzkid]

Hey there Bluelight, so heres the scoop;

2 nights ago me and a buddy tripped on 2ci and MXE combined @ 35mg of 2ci orally and 45mg of MXE nasally @ 2hours in. These doses are only average compared to what we usually take, but we have never tried these two together and we both had strong trips with some of the most pronounced tracers I've ever had in my psychedelic experience and much stronger than 2ci tracers alone; something that surprised me. These trails lasted the whole trip and were so strong that I had a laser pointer and when I would move the dot around a room, the trails would be so long it were as if I was playing a game of snake. The trip overall was so great and the visuals were so unique that the next night, when I had 5 hours of open time I decided I wanted an abbreviated version of the same experience but shorter lasting. Also, I wanted t

o test how tolerance would play a role (as it is usually pretty strong with 2cs) so in order to achieve the shorter trip I lined up what was an equivilent nasal 2ci dose (16mg--2ci nasal doses tend to need roughly half or less of the same amount of material as an oral dose for the same effects for me) as well as 45mg of MXE and snorted them together. Within 30 minutes I was surprised to be right back at the same level as the previous night and continued to be at this level for about 4 hour until I came down and went to bed. Now with the success of having done this 2 nights in a row I have decided I am curious as to whether or not I can do it yet again tonight. I plan on using the same dose as last night and am expecting significantly decreased effect but I wanted to post about my success and make it known that you CAN totally trip on this combo 2 nights in a row and soon we'll see if it can be 3 nights.

Does anyone have similar experience with a surprising lack of tolerance when tripping 2-3 nights in a row on 2ci?

MXE doesnt usually present a tolerance to me, but 2ci does so this is odd that I'm able to do this twice.
What do you guys all think? I know drugs 3 nights in a row isnt that great of an idea, but this is also testing to see if tolerance will play effect when I choose my drug lineup for a 3-day festival this summer.

With all that being said I'd like to open this up to speculation as to why I was able to do this and other people reports regarding multiple day use of 2ci and/or MXE.
Thanks in advance and I'll post my results when I find them.
Nameste!

 

[Yeetbeat]

I have absolutely no idea about MXE as I haven't bothered reading into it at all, so this is 100% pure uninformed speculation - have you considered that perhaps MXE acts as an up-regulator for the particular receptors 2C-I acts on primarily?

 

[Achten]

I have absolutely no idea about MXE as I haven't bothered reading into it at all, so this is 100% pure uninformed speculation - have you considered that perhaps MXE acts as an up-regulator for the particular receptors 2C-I acts on primarily?

This would be my uneducated, but derived from personal experience, guess.

 

[《Plasticity》]

I can't comment on the actual experement (although I wouldn't mind hearing the results) but be careful dosing 2c-i multiple days in a row. Dosing twice in a row caused some pretty prominent visual changes for months for me. I've never had any other psychedelic give me such long lasting and annoying visual after effects after 2 consecutive uses and after doing some digging it seems rather common with 2c-i. I mean I had stronger visuals after the trip then during, it was quite ammusing. Maybe I'm just unlucky though, just a heads up.

 

[thizzkid]

Hey there again, sorry for the late post; i unfortuantely spilled water on my computer the night of this experiment, but as far as the results, they were as I expected. A relatively good tip but slightly weaker than the night before. I head your warning anout continual dosing and am taking a few week break, but the experument proved a success I would say you CAN dose 2ci 3 days in a row and trip each time but tolerance does build.

 

[《Plasticity》]

Hey there again, sorry for the late post; i unfortuantely spilled water on my computer the night of this experiment, but as far as the results, they were as I expected. A relatively good tip but slightly weaker than the night before. I head your warning anout continual dosing and am taking a few week break, but the experument proved a success I would say you CAN dose 2ci 3 days in a row and trip each time but tolerance does build.

Do you feel that the MXE in any way prevented tolerance? I'm not saying go ahead and try dosing another 3 days in a row without the MXE to compare but have you dosed 2c-i consecutively with no MXE prior to this? If so how did the level of tolerance compare. Also just wondering, have you noticed any lingering visuals/static from your 2c-i use? I'm wondering how common it is with 2c-i as I'm not the only one to have that problem but there are factors that likely contributed to my case that I'd rather not get into.

 

[Solipsis]

I was about to post: limit this kind of thing if you don't want HPPD so I am not surprised by the capn's post ^

I would call these doses of 2C-I pretty high and adding MXE is synergistic and I have someone flip out on me on a potent 2C-I cocktail (it was the K and nitrous that did it mainly though maybe methylone and cannabis were also part of it, FWIW it is the nitrous that I would suggest cutting back on since it can be problematic when combined or overused... I haven't used much 2C-I in my lifetime at all).
Anyway dosing high and/or combining can sometimes but not always compensate for tolerance.

 

[thizzkid]

Both your two hypothesis-es seem to hold true to my experience because previously I had taken 14mg 2ci nasally one night and the next day took 45mg orally trying to compensate for tolerance and I still didnt trip as hard during the MXE/2CI combos I did consecutively. Another possible factor I thought may be playing a role is that the order of ROA I used for my cons 2ci in the just 2ci consecutive combos vs. 2ci/mxe combos were reversed meaning that in the just 2ci case I took it nasally the first night and then orally the 2nd night whereas with the MXE/2CI combos were oral dosing then nasal dosing and this was effective even until the third day. So based on that, maybe 2ci presents a higher tolerance when taken orally? My guess would be that his is because the dose is always higher orally so maybe your body just becomes used to 2ci more when taken orally vs nasally.

Also on a side note; I believe I DO have HPPD to a degree caused by many trips on many different compounds, and I cant narrow the cause to any one drug but it isn't anything unbearable and in fact I kind of like it. However that is just my personal opinion and I wouldn't endorse that anyone do what I do. Know your body - know your mind.

 

[《Plasticity》]

The first time I got lasting residual visuals I enjoyed them, watching floor tiles move like water was fun but with 2c-i they also came with a shitload of static that got annoying at night or if I look at bright objects like white paper or even the sky. They went away after quite a few months and cannabis brought them out the most. Anyways you had your experiment and all has been said and done but don't do this again, 3 days is very excessive.