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I Like to Draw Pictures of Random Molecules

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256emhj.jpg


2a8qn8j.jpg


2zhpe1f.jpg
 
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Protip: Ctrl+A, then you should have an option somewhere on the toolbar of your software called "Clean", it'll tidy up those bond angles for you.
 
builder, your cyclised 2c-e is essentially 5-methoxy 6-apdb (i think) and I remember reading either 5-methyl or 5-methoxy 6-apb was active, so i went to find where i read it and all i came across was this - http://en.wikipedia.org/wiki/F-2_(psychedelic) which is pretty damn close. While this F-2 is active but shit, it's known bulk on the heterocycle lowers activity so removal of that methyl might actually get somewhere. I'm not sure why shulgin wanted that bulk on the ring, he made f-22 as well (another methyl on the 2 position). As far as I can see he didn't just make 'F' which is what you suggested. He's an odd man.
200px-F-2.png
 
bk-2c-b dimerisation problem solved by whacking 2,5-dimethoxy 4-Br on the Aminorex phenyl ring! (maybe). I'd guess the DOx (BOx?) derivitive could be done by whacking them on 4-MARs phenyl.

I was thinking about linking th 2 Os by a MD ring, but it would have 6 sides and wouldn't be aromatic at all, mind you it looks tryptamine-y with a bit of rotation and squinting
 
Erm, this thread is, like, for drawing random molecules, not, y'know, like, just describing them, hello, skeletal tits or gtfo
 
chrome os sucks :( use your imagination :D

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I'm bad at coming up with imaginative names, so my buddy came up with this. Great.
 
Don't let sekio see those Texas oxygens, he'll have a hissy fit 8(

Don't know if you could run this but it might be worth a try.
 
"Texas" just refers to hypervalent atoms, like trivalent oxygens as in the pic above, or the classic favourite, pentavalent carbon. I don't know why it's called that, ask someone who learnt chemistry in a school.
 
oh balls here i am doing a chemistry degree, didnt even know. Actually meant to have isofuran but whatevs
 
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No, pyran isn't aromatic. My guess would be that those kavalactones do open up, and that they are prodrugs for the resulting acids.
 
Don't sweat it. Aromatic rings have delocalised electrons, and are resonance structures, yeah? I don't want to patronise you if you know already...
 
I really should think twice before posting shit. Quite embarassing for someone who already had OC1 at university ;)
Thank you for clarifying that.
 
babylonboy said:
No, pyran isn't aromatic. My guess would be that those kavalactones do open up, and that they are prodrugs for the resulting acids.
Click to expand...

Kavalactones have 2-pyrone rings, not pyrans, which have different properties. The 2-pyrone ring is planar and is very difficult to hydrolyze, unlike a lactone ring. I would guess the active product is not the ring-opened form.

Many of the metabolites of the drug have the ring intact or intact and reduced: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085297/#B30
 
Could this Substance hydrolyze into Niacin and Amphetamine? An Amphetamine-Prodrug with an added vasodilator could be useful against the vasoconstriction.

 
idk about it hydrolizing, but niacin's doses are so much higher than methamphetamine's that idk if there would be enough niacin per dose to actually cause any substantial vasodilation
 
Really straight-forward one that I've been bouncing around for a while. Lorcaserin shows that cyclizing the ethanamine side-chain of a PEA into an azepane ring does not eliminate affinity for and efficacy at 5-HT-related targets, at least in terms of the 5-HT2 subtypes anyway. Hopefully that applies to the SERT as well. Hopefully the cyclization of the sidechain is sufficient to stave off MAO without the need for a 6-methyl (equivalent to an α-methyl on a PEA). Thoughts?

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