I Like to Draw Pictures of Random Molecules

[blueberries]

I'm not sure if this has been tested before but:

Possibly a 5-Methyl/Methoxy in there?

 

[pharmakos]

would that be planar like MDMA?

 

[babylonboy]

That oxygen is an epoxide, the strain on the bonds makes it highly, highly reactive. The cyclobutyl group is also strained. It would be difficult and expensive to produce and likely to decompose easily. Yeah, it's planar.

 

[toastmann]

What would happen if you make an amine/amphetamine like compound based on ascorbic acid?

 

[babylonboy]

It gets chopped to shreds by metabolism and doesn't cross the BBB. For a start, it's a lactone, so that ring is going to open up in any acidic or basic environment.

 

[blueberries]

I expect this to be a fairly potent opioid, is there anything inhibiting this?

I threw the ketone group in last minute, just to stabilise/decrease potency/increase opioid activity. It can be removed.

_________________

Also I noticed this earlier in the thread but for some reason it didn't work, I altered it slightly though. This, however is a fairly obvious choice as a successor to TCB-2, so did Nichols make it and it was a dud or what?

 

[MrPorter]

@toastmann, you mean like a 2,5-dihydrofuran ring i guess substituted at 2 with an ethylamine?

 

[Dresden]

4-trifluoromethylmethcathinone

 

[toastmann]

@toastmann, you mean like a 2,5-dihydrofuran ring i guess substituted at 2 with an ethylamine?

Yes you can faintly see the phenethylamine like structure. As in a circular form (benzo/dihydrofuran) shape with the dihydroxyethyl group switch with an ethylamine.

 

[bloodshed344]

It gets chopped to shreds by metabolism and doesn't cross the BBB. For a start, it's a lactone, so that ring is going to open up in any acidic or basic environment.

But so are the kavalactones. Care to explain the difference?

Also I noticed this earlier in the thread but for some reason it didn't work, I altered it slightly though. This, however is a fairly obvious choice as a successor to TCB-2, so did Nichols make it and it was a dud or what?

Ahh, yes! I've thought of this molecule in my head many times! My guess is that it will be more active a psychedelic than MDMA is, but while retaining some characteristics. It may even be mescaline-like.



Dresden, TFM-MCat sounds like a pretty decent chem, but maybe a bit harder on after-effects than regular MCat (knowing how the halogens work there on phenethylamines)

and toastmann, I think you'd have to at least modify the structure a bit to stabilize it. I definitely see the similarity though.

 

[Soulfake]

The 3d-alignments of a Fencamfamine-Tilidine and a Morpholine-Meperidine derivative look quite promising:

http://s7.directupload.net/images/user/131122/m6tfhvkt.jpg

http://s7.directupload.net/images/user/131122/kucrjz9i.jpg

 

[buildersoftime]

I'm assuming something like this has been discussed before?

Or this

Or (while I'm cyclicizing everything in sight) 4,5 cylicized analogues of:

2c-d

2c-e

2c-p

Then there are the respective hemi-fly analogues which would all be UK legal. 4,5 cyclicized analogues of:

2c-d-hemi-fly

2c-e-hemi-fly (this one should be called MickyMouse)

2c-p-hemi-fly

And finally (because it's beautiful) MickyMouse-AI

 

[babylonboy]

Would those saturated cyclic ethers not be considered alkoxy substitutions under the MODA? Is there any precedent? bromo-dragonfly would be considered class A, no? I like your DOM-indane, pretty thing.

 

[Transform]

The UK MoDA did not cover 6-APDB (they temp scheduled it specifically) so would not cover that. Good chance that at least a few of those would be pleasantly active, the problem would be the expensive synthesis - puts of the profiteers that run the industry if they aren't certain they'll be profitable.

 

[babylonboy]

They only temp scheduled it this year, and no UK vendors were selling it before that (early batches of 6-APB were raved about, then it transpired they were likely the reduced analogues and pulled from sale, no?). It's interesting, though, I'd agree with you, it seems they've actually implicitly stated that benzodihydrofurans aren't covered when the industry had assumed they were and policed itself.

 

[piller97]

This is actually the most wonderful thread I've ever seen because this is pretty much the relativity of quite a few stimulant users.

fabulous idea

 

[Albion]

 

[sekio]

What is that, a K-hole?

 

[Transform]

Reminds me of cancerdrone

 

[babylonboy]