• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
I'm not sure if this has been tested before but:

JjimXE1.jpg


Possibly a 5-Methyl/Methoxy in there?
 
That oxygen is an epoxide, the strain on the bonds makes it highly, highly reactive. The cyclobutyl group is also strained. It would be difficult and expensive to produce and likely to decompose easily. Yeah, it's planar.
 
What would happen if you make an amine/amphetamine like compound based on ascorbic acid?
620px-L-Ascorbic_acid.svg.png
 
It gets chopped to shreds by metabolism and doesn't cross the BBB. For a start, it's a lactone, so that ring is going to open up in any acidic or basic environment.
 
I expect this to be a fairly potent opioid, is there anything inhibiting this?

tOlX3vQ.png


I threw the ketone group in last minute, just to stabilise/decrease potency/increase opioid activity. It can be removed.

_________________

Also I noticed this earlier in the thread but for some reason it didn't work, I altered it slightly though. This, however is a fairly obvious choice as a successor to TCB-2, so did Nichols make it and it was a dud or what?

jNGJY1O.png
 
Last edited:
@toastmann, you mean like a 2,5-dihydrofuran ring i guess substituted at 2 with an ethylamine?
 
MrPorter said:
@toastmann, you mean like a 2,5-dihydrofuran ring i guess substituted at 2 with an ethylamine?
Click to expand...

Yes you can faintly see the phenethylamine like structure. As in a circular form (benzo/dihydrofuran) shape with the dihydroxyethyl group switch with an ethylamine.
 
babylonboy said:
It gets chopped to shreds by metabolism and doesn't cross the BBB. For a start, it's a lactone, so that ring is going to open up in any acidic or basic environment.
Click to expand...

But so are the kavalactones. Care to explain the difference?


blueberries said:
Also I noticed this earlier in the thread but for some reason it didn't work, I altered it slightly though. This, however is a fairly obvious choice as a successor to TCB-2, so did Nichols make it and it was a dud or what?

jNGJY1O.png
Click to expand...
Ahh, yes! I've thought of this molecule in my head many times! My guess is that it will be more active a psychedelic than MDMA is, but while retaining some characteristics. It may even be mescaline-like.



Dresden, TFM-MCat sounds like a pretty decent chem, but maybe a bit harder on after-effects than regular MCat (knowing how the halogens work there on phenethylamines)

and toastmann, I think you'd have to at least modify the structure a bit to stabilize it. I definitely see the similarity though.
 
I'm assuming something like this has been discussed before?

2epk9w2.jpg


Or this

21cuu6u.jpg


Or (while I'm cyclicizing everything in sight) 4,5 cylicized analogues of:

2c-d

5mmln5.jpg


2c-e

2uxv4tc.jpg


2c-p

29kq1ko.jpg


Then there are the respective hemi-fly analogues which would all be UK legal. 4,5 cyclicized analogues of:

2c-d-hemi-fly

10g00tf.jpg


2c-e-hemi-fly (this one should be called MickyMouse)

oksfti.jpg


2c-p-hemi-fly

2liwt2a.jpg


And finally (because it's beautiful) MickyMouse-AI

2j17fih.jpg
 
Last edited:
Would those saturated cyclic ethers not be considered alkoxy substitutions under the MODA? Is there any precedent? bromo-dragonfly would be considered class A, no? I like your DOM-indane, pretty thing.
 
The UK MoDA did not cover 6-APDB (they temp scheduled it specifically) so would not cover that. Good chance that at least a few of those would be pleasantly active, the problem would be the expensive synthesis - puts of the profiteers that run the industry if they aren't certain they'll be profitable.
 
They only temp scheduled it this year, and no UK vendors were selling it before that (early batches of 6-APB were raved about, then it transpired they were likely the reduced analogues and pulled from sale, no?). It's interesting, though, I'd agree with you, it seems they've actually implicitly stated that benzodihydrofurans aren't covered when the industry had assumed they were and policed itself.
 
Status
Not open for further replies.
Top