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Opioids Oxymorphone Rectal Administation Bioavailability

-Hydromorphone-

-Hydromorphone-

Greenlighter
Joined
Oct 9, 2013
Messages
3
Location
New Orleans, La
Hi. I was wondering if anyone knew what Oxymorphone's rectal bioavailability was. :?
I can't seem to find any information on this anywhere on the web.

I was hoping it would be higher than nasal bioavailability so that I could get around snorting or taking due to low bioavailability.
Maybe I could save myself cash. Answering this could potentially help many people.
 
I figured the same due to nasal/rectal having the same mucous membranes, but sometimes they differ. (ex. Morphine)
I'm really asking for an approximate percentage.
 
-Hydromorphone- said:
I figured the same due to nasal/rectal having the same mucous membranes, but sometimes they differ. (ex. Morphine)
I'm really asking for an approximate percentage.
Click to expand...

Doesn't exist in literature that we would be able to access... But, it is stated to be just as effective.

This question comes up at least once in a while. I used the search engine and came up with the old threads posted here on bluelight and elsewhere...
 
-Hydromorphone- said:
I wonder why there isn't any detailed information on this, though.
Click to expand...

It is a very uncommon and unnecessary ROA for this drug.

There are better drugs suited for rectal and nasal administration medically.

Nasal and rectal are as good as it gets and that is a little over half.

Drfeelgood87 said:
The rectal B/A is around 85%. The key issue here is how much fluid retention your colon has.
Click to expand...

That's for Oxycodone...
Source?
 
Here's a study on the subject:

A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain.

Abstract
The relative analgesic potency of oxymorphone by rectal suppository and intramuscular injection was evaluated in a double-blind, twin-crossover comparison of graded single doses in 136 patients with postoperative pain.
The time-effect curves of the two routes of administration differed substantially; rectal resulted in lower and more delayed peak analgesia and a longer duration of action than intramuscular administration.
When both duration and intensity of analgesia are considered (total effect), rectal oxymorphone was 1/10 as potent as the intramuscular form; in peak effect, it was only 1/16 to 1/20 as potent. However, because intramuscular oxymorphone is nine to ten times as potent as intramuscular morphine, 5 to 10 mg oxymorphone by suppository provides analgesia comparable to that provided by the usually used doses of parenteral narcotics.
Rectal oxymorphone produced no more, and perhaps somewhat fewer, side effects than doses of intramuscular oxymorphone producing equivalent total analgesic effect.
- source
 
littlepenguin said:
Here's a study on the subject:

A comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain.

Abstract
The relative analgesic potency of oxymorphone by rectal suppository and intramuscular injection was evaluated in a double-blind, twin-crossover comparison of graded single doses in 136 patients with postoperative pain.
The time-effect curves of the two routes of administration differed substantially; rectal resulted in lower and more delayed peak analgesia and a longer duration of action than intramuscular administration.
When both duration and intensity of analgesia are considered (total effect), rectal oxymorphone was 1/10 as potent as the intramuscular form; in peak effect, it was only 1/16 to 1/20 as potent. However, because intramuscular oxymorphone is nine to ten times as potent as intramuscular morphine, 5 to 10 mg oxymorphone by suppository provides analgesia comparable to that provided by the usually used doses of parenteral narcotics.
Rectal oxymorphone produced no more, and perhaps somewhat fewer, side effects than doses of intramuscular oxymorphone producing equivalent total analgesic effect.
- source
Click to expand...

That is comparing it to intramuscular administration.

The census is that it is not that effective all the way around besides iv for oxymorphone delivery.
 
Psychedelic Jay said:
That is comparing it to intramuscular administration.

The census is that it is not that effective all the way around besides iv for oxymorphone delivery.
Click to expand...

yes, psychedelic jay, I am aware that the subject of the study is comparing oxymorphone's rectal bioavailability with oxymorphone's intramuscular bioavailability, mostly because I read the title of the study before I posted it, and since the title contains the phrase "...comparison of the analgesic effect of oxymorphone by rectal suppository and intramuscular injection..." but reminders are always appreciated.

after a long search through reliable source materials, the study I mentioned above was probably the closest I could find, in reference to what the OP was asking for. it's difficult, as you stated earlier, to find the accurate information that lists rectal bioavailability percentages in oxymorphone and many other drugs. I figured that even though the OP was seeking a percentage and was comparing nasal to rectal (which, again, I could not find literature on) I figured that one who was interested in the subject may be able to draw conclusions from the information at hand better than drawing conclusions from no information at all - which you did draw your conclusion, saying the 'census is that it is not that effective all the way around besides IV for oxymorphone delivery.'

The last part of the study's abstract that I didn't post:

"Rectal oxymorphone produced no more, and perhaps somewhat fewer, side effects than doses of intramuscular oxymorphone producing equivalent total analgesic effect.
This study demonstrates the feasibility of well-controlled analgesic assays employing the double-dummy technique to compare suppositories with oral or parenteral analgesic dosage forms.
Our observations also suggest that the rectal route is an acceptable and practical way of administering potent analgesics and is probably being underutilized by physicians in the control of moderate to severe pain."

-see source link in my previous post

now, even though that study does not compare nasal vs. rectal specifically, nor does it give specific percentages of bioavailability that the OP wanted - it still shows the OP that in conclusion, the rectal route is an acceptable and practical way (and possibly more harm reductive) of administering potent analgesics (oxymorphone).
 
I thought it was potent enough sniffed.. with lowish tolerance 2mg insuffulated 5mg smoked (of opana IR) had me feeling quite H'd out.
 
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