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Ketamine and Trileptal (oxcarbazepine) Interaction

NeuroDr

Bluelighter
Joined
Aug 20, 2008
Messages
924
Ive been on trileptal, used as a mood stabilizer in my case, for about a month and a half now and I just stumbled across some Ketamine. Was wondering if anyone can shed some light on some possible interactions between these two and/or if it is a safe move ingesting some Ketamine?

Thank you

Neuro
 
no one has any clue or pharmazology background to help a little with thsi??? P p P Pleaaaase ;)
 
Oxcarbazepine is an inducer of CYP3A4. A lot of drugs metabolised through CYP3A4 (they're called CYP3A4 Substrate). Some almost totally, others let's say 50%, and others less (maybe 5%, etc.). Now there are some drugs that are CYP3A4 Inhibitors, and some that are CYP3A4 Inducer.
The inhibitor, when it's taken with a CYP3A4 Substrate, it raises the substrate's level in the plasma, we can say that it's like you take more of the substrate drug..and the inducer it's the opposite, it it's like it makes the substate drug weaker, it lowers the drug's level in the plasma..
As an example, you take 4 pills of a CYP3A4 Substate drug, with oxcarbazepine, and it's like you took 3 pills of this drug..Well, this is a very simple explanation, but if you google for CYP3A4, you'll understand everything..
this http://www.pharmacologyweekly.com/content/pages/medications-herbs-cytochrome-p450-cyp-enzyme-inhibitors will make the things easy, i think..when you're in, click for CYP3A4 Inducers...



MartinFn

*edit*As i see in the tables in the link above,oxcarbazepine is a CYP3A4 Inducer, and ketamine is CYP3A4 Substrate, so in theory, trileptal would lower the ketamine's plasma level, and would make the ket "weaker"..but actually it doesn't..(cause oxcarbazepine isn't a strong inducer). I was taking trileptal, at dose 3x300mg, together with a drug that was almost totally metabolised through CYP3A4, and it didn't affect it at all..so...but fuckin anyway, you can always check for drug's interaction here http://http://www.drugs.com/drug_interactions.php. Be safe and have a great time my friend..:)
 
Last edited:
Wow man thanks a lot, i'll definitely check out those links. ive gotten so behind on my neuroscience since i graduated. its sad :/ but i'll do some reading and get back up to speed..thanks again, exactly the info i needed
 
Do you still need information on ketamine?
I have used the drug for pain from rheumatoid arthritis for years.
I am in Nashville, TN.
LLS207
 
Wow man thanks a lot, i'll definitely check out those links. ive gotten so behind on my neuroscience since i graduated. its sad :/ but i'll do some reading and get back up to speed..thanks again, exactly the info i needed

Hey man,
i'm glad if i helped you, even a litl..just for the record, there're weak and strong inhibitors (and inducers), and practically this means that a weak one may have no diff in the bioavaility, but a strong one can increase the bioavailability even more than 100% (as i've found..). Thanx for your kind words my friend, wish you a nice day and always be safe..%):)


MartinFn
 
Do you still need information on ketamine?
I have used the drug for pain from rheumatoid arthritis for years.
I am in Nashville, TN.
LLS207

No I got the information I needed I think. Thank you for offering though. Any more information is always welcome as the more information out there the better
Hey man,
i'm glad if i helped you, even a litl..just for the record, there're weak and strong inhibitors (and inducers), and practically this means that a weak one may have no diff in the bioavaility, but a strong one can increase the bioavailability even more than 100% (as i've found..). Thanx for your kind words my friend, wish you a nice day and always be safe..%):)


MartinFn

You as well brother. I have since gone thru all my K without issue and had a fantastic K Hole last night. So thanks again everyone

Peace, love n light <3
 
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