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Combating diarrhoea induced by psychedelics/empathogens

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David the Chansey

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Joined
Jul 21, 2012
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262
Hello. I always get diarrhoea on the come-up of just about every drug I've tried. Usually this doesn't bother me too much, because most of my drug experiences start indoors. However, since my recent exploration of psychedelics (particularly the 25X-NBOMe series), it annoys me that I have to stay home during the come-up. Especially now that I'm living with my parents for a while, I don't want to be caught on drugs, so I'd much rather take them outdoors.

Does anyone have any suggestions to prevent diarrhoea on the come-up? I was thinking of taking Imodium. Would this be safe/effective? If so, when should I take it relative to taking the drug? Thanks for reading, and I look forward to hearing your responses.
 
Hah you know I've had this thought before myself. I've yet to encounter it but I always wondered how I would handle having to go to the washroom that urgently while spaced out of my mind on say something like mushrooms.. Just the thought of having to process the need of having to exit my current state of bliss and find a washroom asap seems pretty daunting.. If you're out in the woods just let it go.. but how do you clean up then? Nightmare..

Interested in answers as well!
 
Whatever you do try to combat it, do try it works first and not decide to trip in the middle of nowhere!
 
Imodium or loperamide is basically an opioid drug (like the painkillers) that doesn't reach the brain to an appreciable extent - let's not go into that for now.

You can take 4 mg and depending on the form, if you simply take tablets it would act in about 1-3 hours and last about 30-40 hours. Therefore I would wait the 3 hours just to be sure if I were you.
If you want to be very precautious you can try 1 or 2 mg first although I don't find that much of a margin for an "allergy test" especially with a drug that isn't risky like acting on your autonomous system. Still it is smart to be aware of possible side-effects, most of all because you may experience them more intensely during a psychedelic trip.
An example is that if you are sensitive to loperamide, it could potentially work so well that it causes obstipation, I'm not sure.

But I don't see why combining it would be unsafe. The way it acts is very different from that of psychedelics and whether it is psychoactive itself is a controversial topic. For our intents and purposes we can probably say it isn't.

Not sure what the mechanism is here, if there is some pharmacological action on your GI tract or if this is your body's way of dealing with anxiety. Have you had this problem in the past as well when there weren't drugs involved, but anxiety was?

I'd test a sufficient dose of anti-diarrhoeal medication with a low dose of a psychedelic first and slowly work my way up as if I were a beginner. And yes, make sure that your set and setting accodomate complications if you don't get it to work, or not right away.

Good luck. :)
 
I really wonder about the variability of GI symptoms from psychedelics. I've never had a stomachs ache, let alone diarrhea, from a psychedelic drug, yet my friend K will get stomach pains and cramps from most any tryptamine and some PEAs during the come up. I know that there are 5-HT receptors of various subtypes within the gun tissues, so it should seem that GI distress would be a natural outgrowth of the stimulation of these receptors in an unusual way. And yet there seems to be no rhyme or reason to who gets stricken and who gets away without a scratch.

Sure, I generally have a cast iron stomach. But this is equally true for my friend K, and his girlfriend who has nearly constant GI problems paradoxically doesn't get much in the way of symptoms from psychedelics.

I wonder how much diet may affect this. K eats tons of unhealthy shit and lots of red meat, I don't eat meat or fish and what foods I do eat are generally healthy, cooked but not over-processed foods. I am not going to get on the ludicrous 'all meat is bad' nonsense, but I think that eating tons and tons of the stuff is probably no good, the same as eating tons and tons of anything to the point of neglecting to consume a variety of different foods is bad. But this is pure speculation on my part, and just to throw my theorization even further off base his girl eats essentially nothing but candy, so her lack of GI problems from psychedelics is most unusual, as eating nothing but candy must be infinitely worse than eating nothing but red meat.

One more instance of a question that is likely easily answered if double-blind studies were to be conducted, but they can't be conducted due to the oppressive, stifling atmosphere for basic researchers that results from prohibition.
 
Does it happen with tryptamines? I've never had this occur with trypts but have definitely had this feeling on 2c-e and 2c-b when your having one of those laugh fest trips where your lungs hurt from all the laughing and all the sudden get that "holy shit I almost just shit my pants feeling" and then have had to take a few trips to the bathroom during the trip, the feeling seems to get more intense when re dosing. So I guess I would suggest going with a 4-sub-trypt if you're trying to avoid this as I've had some stomach cramps during almost all of my mushroom trips, plus tryptamines are a lot more outdoor friendly and natural feeling as that seems to be what you're looking for.
 
Thanks for all the responses. I never expected so many. :) I believe the problem is not caused by anxiety of taking the drug. It is worth noting though that I naturally release more adrenaline than most people, causing hyperhidrosis (excessive sweating) all over the body, and a natural feeling of being "on edge" all the time (blessing me with incredible unconscious reaction times, which have proved useful many a time). My diet is reasonably good. Not perfect though.

I naturally use the toilet to urinate and defecate quite often, more often than anyone else I know. My metabolism is pretty rapid. I guess one could say I am unconsciously anxious, and this could well be the reason for my troubles. It is a nuisance, though, and it has put me off taking drugs at clubs very often.

Hell, even caffeine gives me sloppy shits. One cup of tea, and boom. Needless of me to mention caffeinated energy drinks (Monster truly is an appropriate name).

I shall try Imodium next time. I've tried it before for treating more naturally caused diarrhoea, and I am comfortable thinking that I won't have a negative reaction to it. I'm glad to hear that it is unsuspected to react badly with psychedelics, and I hope it doesn't have a negative impact on the high at all.

I'll be sure to report back when I try it. It makes me optimistic to hear that it has worked for other people. :)
 
Hmmm, that's not really the norm. I know some of the entheogens do that (don't they say 5-MeO-DiPT causes 'foxy trots or something? And alpha-O-DMS is notorious for that). Caffeine will make the colon active, it's actually known for that and is considered to help prevent cancers down there. The psychedelics don't tend to do this so it probably is a stress reaction, it could be diet, or both. The psychedelics are not adrenalin releases to any great degree....not to my knowledge anyway.

Yeah you could try *more drugs* to combat the effects of the other drugs but I always try to complicate things by finding out *why* instead of how to cover it up so never mind me!
 
David the Chansey said:
Thanks for all the responses. I never expected so many. :) I believe the problem is not caused by anxiety of taking the drug. It is worth noting though that I naturally release more adrenaline than most people, causing hyperhidrosis (excessive sweating) all over the body, and a natural feeling of being "on edge" all the time (blessing me with incredible unconscious reaction times, which have proved useful many a time). My diet is reasonably good. Not perfect though.

I naturally use the toilet to urinate and defecate quite often, more often than anyone else I know. My metabolism is pretty rapid. I guess one could say I am unconsciously anxious, and this could well be the reason for my troubles. It is a nuisance, though, and it has put me off taking drugs at clubs very often.

Hell, even caffeine gives me sloppy shits. One cup of tea, and boom. Needless of me to mention caffeinated energy drinks (Monster truly is an appropriate name).

I shall try Imodium next time. I've tried it before for treating more naturally caused diarrhoea, and I am comfortable thinking that I won't have a negative reaction to it. I'm glad to hear that it is unsuspected to react badly with psychedelics, and I hope it doesn't have a negative impact on the high at all.

I'll be sure to report back when I try it. It makes me optimistic to hear that it has worked for other people. :)
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Hmm, have you ever been checked our for hyperthyroidism? One of my friends had thyroid issues and that sort of 'always on edge' weirdness was exactly what they described prior to beginning treatment. Obviously I'm not a medical doctor and even if I were diagnosis over the Internet is pretty much guaranteed to be based purely on speculation, but if I were you I would get it checked out, as the edginess, and definitely the excessive sweating are symptoms of thyroid abnormality. Extra frequent defecation and to a lesser extent urination are also prime symptoms.

morninggloryseed said:
Hmmm, that's not really the norm. I know some of the entheogens do that (don't they say 5-MeO-DiPT causes 'foxy trots or something? And alpha-O-DMS is notorious for that). Caffeine will make the colon active, it's actually known for that and is considered to help prevent cancers down there. The psychedelics don't tend to do this so it probably is a stress reaction, it could be diet, or both. The psychedelics are not adrenalin releases to any great degree....not to my knowledge anyway.
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Interesting, I didn't know that about caffeine. I would hazard a guess to the effect that keeping things moving in the large intestine may prevent bacteria, viruses or the digested remains or indigestible pieces of certain foods that are known to be carcinogenic (the charred, tasty parts of grilled meats for example) from sitting in place in the colon and large intestines. That way the bacteria/viruses/carcinogenic post-digestion remnants of food don't sit in a single place making physical contact with a single spot on the wall of the L. intestine / colon, allowing more time for that spot to potentially become cancerous.

That's just a guess, but either way I'm glad I drink coffee then! For many reasons, but being less likely to get colorectal cancer is certainly a definite plus.

On the subject of adrenalin, I know that some psychedelics to have affinity for the arenaline receptor family, like LSD. I don't know about other tryptamines or the PEAs however, and in acid I'm pretty sure the level of affinity is low enough that it doesn't really matter as far as producing noticeable effects when one considers how small the doses for LSD and this how low the resulting concentrations are in the body.
 
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Ok so 4mg of Loperamide was taken almost 4 hours ago, and 200mg 6-APB taken just. If this settles my bowls then I'm in for a winner. I will report back.
 
It worked at first, and then it didn't.

A few days ago I had 1.5mg 25I-NBOMe. I smoked weed during the come up and didn't get any bowel movements at all. Think the weed helped? Usually, even just 1mg gives me diarrhoea .
 
Good chance actually, one of the uses of medical marijuana is combating GI ailments so it could have helped
 
If taking loperamide before eating/drug taking isn't working you're not likely to find a cure. When diarrhea is caused by drugs usually 5HT3 agnoists or stimulants are involved. There's an off chance 5HT3 antagonists could help, but if you don't use any other drugs and have a decent diet you should see a doctor since what you describe is not normal.
 
David the Chansey said:
It worked at first, and then it didn't.

A few days ago I had 1.5mg 25I-NBOMe. I smoked weed during the come up and didn't get any bowel movements at all. Think the weed helped? Usually, even just 1mg gives me diarrhoea .
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given cannabis's positive effects on Irritable Bowel Syndrome, this should come as no surprise. You have your answer now: smoke pot :)
 
I really think I should see a doctor about this, as it is concerning me now. I've had my thyroid tested before and that's fine.

I'm going to take 3mg 25D-NBOMe 3 hours after taking 4mg Loperamide. This didn't work for 6-APB, but I'm hoping it'll work for this substance.
 
+1 on the Immodium tip. If you have a tolerance to opiates you can try more than 4mg. Takes a couple hours to really work effectively. Since it doesn't reach the blood-brain barrier it shouldn't interact with the trip. However, it's true there are serotonin receptors in our digestive tract and these psychedelics are generally agonists of these types of receptors.
I also agree Cannabis can help.
 
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