bennyZA
Bluelighter
I don't think anyone knows anything about lope's effects on other people. Shit is so weird.
Opioids Looking for info...
- Thread starter StartedHydro
- Start date
lolwhatzdrugs
Bluelighter
This is true. Does it block effects for some people? Or did it just raise your tolerance?
If you were taking massive doses of loperamide to stave of withdrawal it can raise your tolerance more than you think. It's odd since the pleasurable effects are caused by the MU receptors in the CNS. How would it raise CNS tolerance? I know small amounts get through, but I am convinced that almost ALL withdrawal symptoms are mediated by the PNS.
What I wonder is if all opioids were taken with Methylnaltrexone therefore antagonizing your PNS, would withdrawal occur?
"Methylnaltrexone (MNTX, trade name Relistor) is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. "
I don't believe that last part. If I took a peripheral antagonist I would feel like I was dying, is my guess.
What I want to know if all opioids were mixed with a peripheral antagonist from the beginning so that they are now only pain killers and cannot work for diarrhea, but if you never agonize the PNS, would you still have withdrawal. Again my hypothesis is that ALL (or at least the shitty symptoms -no pun intended
) are mediated by the PNS.I *think* naltroxene, when taken with morphine, is supposed to help preserve the pain-killing effects and stave off tolerance. I don't have a link and can't be bothered to search. I believe the study was conducted at the University of Colorado, if you're interested. I haven't read up on Relistor, but I am not personally enthusiastic about the idea.
'medicine cabinet'
Bluelighter
Drug interactions are fascinating bc everyone is different but also bc of the complex interaction esp with opis at that level. Im not doubting that loperamide could block other things, but a 48mg shot of dilly?? Wow. First that is like 20x a normal shot so i know you have a massive tolerance. And to the poster who slammed 60mg of oc and 60 of aderal, you really didnt feel anything? Bc im thinking im in the same boat. I dont do stims but not being able to feel a shot again is disheartening...i know it shouldnt be, but it is.
I'm not talking shite. I've been on opioid pharmacotherapy for many years now, and yes my tolerance is high due to abuse. I've slammed IV heroin, opanaER, opana IR, hydromorphone, morphine, and some few benzos. It just didn't work..for days.
'medicine cabinet'
Bluelighter
Im on close to 100mgs of mmt a day so yea i know where youre coming from. Sucks dont it?
StartedHydro
Bluelighter
- Joined
- May 29, 2006
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Another thing I have learned over the years in regards to oxycodone, its a lot weaker than its rep. The whoop la that surrounds oxycodone is way more potent than the actual substance. I have an average tolerance with regards to opiates/opioids. I would say around 40-70 mg of a fairly strong opiate/opioid will generally have me feeling good. I have tried all the opiates/opioids that I have come across. The way Oxy is portrayed its as if its the be all end all of painkillers. The way it's(Oxy) listed as a C2, how media brainwashs people's mind, and how some doc's respond if you mention it's name gives the impression that Oxy should be the gold standard not morphine.
I had this morning upon waking 90 mg(most prob around 77-83 mg-lost to goop and cotton) IVed and after 2 mins It had me thinking, due to the lack of being satisfied. Sure it took me out of the AM WDs, but its a rather empty feeling. No profound euphoria, no burst of energy, no motivation... Just blah. I fully understand that Oxy has zero rush IVed, was never expecting that part. I just think Oxy is way over rated and sceduled wrong to, it should be a C3.
If I had IVed 90 mg of H I would had be floored out of my mind, but that's not the point. If I would had done around say 20-40 mg of H first thing in AM I would had got instantaneous energy, great motivation, powerful euphoria, ADHD would vanish, work becomes fantastic.
Oxy, IMO, should be clumped with hydro, tapentadol(another opioid which should be C3) M1(tramadol metabolite). Oxy should be with Hydro, codeine, Dihydro, tramadol, tapentadol, and all the other C3, C4, C5.
It's way over hyped and relatively weak.
I had this morning upon waking 90 mg(most prob around 77-83 mg-lost to goop and cotton) IVed and after 2 mins It had me thinking, due to the lack of being satisfied. Sure it took me out of the AM WDs, but its a rather empty feeling. No profound euphoria, no burst of energy, no motivation... Just blah. I fully understand that Oxy has zero rush IVed, was never expecting that part. I just think Oxy is way over rated and sceduled wrong to, it should be a C3.
If I had IVed 90 mg of H I would had be floored out of my mind, but that's not the point. If I would had done around say 20-40 mg of H first thing in AM I would had got instantaneous energy, great motivation, powerful euphoria, ADHD would vanish, work becomes fantastic.
Oxy, IMO, should be clumped with hydro, tapentadol(another opioid which should be C3) M1(tramadol metabolite). Oxy should be with Hydro, codeine, Dihydro, tramadol, tapentadol, and all the other C3, C4, C5.
It's way over hyped and relatively weak.
lolwhatzdrugs
Bluelighter
I know this may seem shocking to you, but these drugs are not grouped by how subjectively good they feel, they're grouped by their ability to cause physical dependence. Hence the low potency ones (codeine) being less restricted and the high and super high potency ones ranging from schedule I-III.
Now I only speak for the opioids. As we all know cannabis is schedule 1, yet methamphetamine and cocaine are schedule 2. (Though it is claimed this is due to the medical uses of methamphetamine and cocaine, yet despite marinol, an Rx being pure THC, cannabis is useless, so says the agency which gets more money the more chemicals that are *dangerous*, but that's another topic)
The ONLY reason hydrocodone is schedule 3 at all is because it is compounded with acetaminophen, if you check the CSA hydrocodone in pure form is a schedule 2 drug. Hydrocodone and oxycodone are very close in effects, though equivalence charts put 5-6.7mg of oxycodone and 10mg of hydrocodone (both orally) to 10mg of oral morphine.
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Is it heroin you're used to? Then you'll be disappointed because the opiates (poppy compounds- morphine/codeine) and heroin (a prodrug of morphine) are all far more euphoric.
In fact the only thing I've had which has compared and perhaps beaten pure morphine (RX pills) in euphoria has been poppy tea, which is a water soluble extract of poppy pods and therefore a blend of primarily morphine and other physiologically active compounds - though these extra compounds are not necessarily euphoric they sure add some kind of effect that increased the perceived euphoria, and possibly the duration.
Oxycodone has never been portrayed as the most euphoric drug around as far as I'm concerned, that title has always seemed to go to heroin.
But in my opinion, if you have a lower tolerance or a whole shit ton, poppy pods win for euphoria, smoothness and duration that heroin or RX morphine cannot even begin to touch. And trust me, I've done almost every RX (only orally/nasally/rectally) and H (rectal and IV).
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I've done oxymorphone and it beat the shit out of any heroin I've done. It was up the nose, and IMHO, even beat the H iv. I'd say maybe hydromorphone had the best rush of any ope I've done, but oxymorphone definitely takes the cake with euphoria, potency, and general effects.
Course the only time I did it I got it free because I traded her some 4mmc for it and some other shit. And no idea how much i did because i got fucked up and forgot. Oh I miss you mephedrone.. So many essentially free drugs, no more... Still, I think I was being pretty objective effects wise.
Course the only time I did it I got it free because I traded her some 4mmc for it and some other shit. And no idea how much i did because i got fucked up and forgot. Oh I miss you mephedrone.. So many essentially free drugs, no more... Still, I think I was being pretty objective effects wise.
lolwhatzdrugs
Bluelighter
How the heck would you know how objective you were being? You kinda need a consensus for objectivity
Now I will admit that hydro/oxy-morphone are two drugs which I have never taken. Well, I took hydromorphone, but orally, and probably not near enough to have an opinion. I'd need ampules of either if I was ever going to truly try them, and since that is unlikely, and I'm not shooting pills available to me, I'll probably never know.
I just looked at a thread rating subjective euphoria, and the finalists seem to be heroin, morphine, and hydromorphone (some say only when IVed).
Though technically morphine and heroin are as good as the same thing, since heroin only makes it to the brain quicker, but there becomes morphine. Anyway, this has gotten way off topic, and I've had enough of this subject.
Umm well I shouldn't have really said objective because its my experience which is entirely subjective. I guess I misspoke, but I mean to say it felt the best of any other opiate.
I would said overall I would said dilaudid iv wins for rush, heroin for best overall iv experience, but best all-around would be intranasal oxymorphone. Idk what iv oxymorphone is like but I'd expect it to be similar to heroin.
I just remember laying outside under the stars of our "headquarters" I'll call it - where everything went down - on the mattress in total bliss. Felt so clean and I was smacked out but it was one of a couple times I've ever not been nauseous while actually getting some that kind of euphoria. Opana takes the cake.
P.S. I've never iv'd morphine but isn't heroin more potent and euphoric because of 6mam metabolite?
I would said overall I would said dilaudid iv wins for rush, heroin for best overall iv experience, but best all-around would be intranasal oxymorphone. Idk what iv oxymorphone is like but I'd expect it to be similar to heroin.
I just remember laying outside under the stars of our "headquarters" I'll call it - where everything went down - on the mattress in total bliss. Felt so clean and I was smacked out but it was one of a couple times I've ever not been nauseous while actually getting some that kind of euphoria. Opana takes the cake.
P.S. I've never iv'd morphine but isn't heroin more potent and euphoric because of 6mam metabolite?
Sprout
Bluelight Crew
Be careful jumping from Tram to H. I had a very brief dalliance with H, and a long love affair with Tram, though both carry significant risks - I'd stick to Tram.
lolwhatzdrugs
Bluelighter
I don't see anything in the wiki article suggesting that 6-MAM is even more potent than heroin.
But remember, potency isn't linear at all with euphoria. Fentanyl is FAR more potent then almost every opioid (other than fentanyl analogs) and most people say it certainly isn't as euphoria as heroin.
What makes heroin euphoric? Is it the active metabolite 6-MAM, or the other active metabolite morphine? I don't know at what ratio these occur in your blood and the relative potency. Honestly, as I've said, morphine and poppy tea have been the most euphoric things I've ever taken, even more so than IV heroin, even more so than pharmaceutical morphine. These effect profiles are odd. I mean, why do I feel that way? Is it other non-mu-opioid chemicals that alter the perception of morphine? Is a full spectrum extract of the poppy plant a more effective analgesic (anal lol) than purified morphine HCl? Or is it just more euphoric?
I don't know if any of these questions have been answered, but I'd be willing to volunteer for an experiment on subjectivity!
How come the rats get to have all the fun? I'd do it, but no hot plate test. They can do the tail prick one as I am lacking that feature.